Supplementary Table 2. Gossypol-induced Decrease of Levels of Reduced Cysteine-containing Peptides

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1 Supplementary Table 2. Gossypol-induced Decrease of Levels of Reduced Cysteine-containing Peptides Accession Description Sequences of Cys-containing peptides IPI protein zeta/delta DICNDVLSLLEK IPI kda protein HELQANCYEEVKDR KAVLFCLSEDKK IPI S ribosomal protein L46, FLGNAPCGHYTFK IPI S ribosomal protein S11 CPFTGNVSIR IPI S ribosomal protein S17 VCEEIAIIPSK IPI S ribosomal protein S2 KLLMMAGIDDCYTSAR IPI S ribosomal protein S3 GLCAIAQAESLR IPI IPI IPI S ribosomal protein S3a 40S ribosomal protein S4, X isoform 40S ribosomal protein S5 ACQSIYPLHDVFVR NCLTNFHGMDLTR FDTGNLCMVTGGANLGR LRECLPLIIFLR KAQCPIVER RVNQAIWLLCTGAR TIAECLADELINAAK IPI S ribosomal protein S8 LDVGNFSWGSECCTR IPI kda heat shock protein, AAVEEGIVLGGGCALLR CEFQDAYVLLSEK IPI S acidic ribosomal protein P0 AGAIAPCEVTVPAQNTGLGPEK IPI S ribosomal protein L10 VDEFPLCGHMVSDEYEQLSSEALEAAR IPI S ribosomal protein L10a FSVCVLGDQQHCDEAK VLCLAVAVGHVK IPI S ribosomal protein L17 INPYMSSPCHIEMILTEK IPI S ribosomal protein L18 GCGTVLLSGPR IPI S ribosomal protein L23 ISLGLPVGAVINCADNTGAK IPI S ribosomal protein L27a NQSFCPTVNLDK IPI S ribosomal protein L30 TGVHHYSGNNIELGTACGK IPI S ribosomal protein L32 SYCAEIAHNVSSK IPI IPI S ribosomal protein L4 60S ribosomal protein L5 RGPCIIYNEDNGIIK YAICSALAASALPALVMSK DIICQIAYAR VGLTNYAAAYCTGLLLAR IPI S ribosomal protein L7 YGIICMEDLIHEIYTVGK IPI S ribosomal protein L7a KTCTTVAFTQVNSEDKGALAK MGVPYCIIK IPI S ribosomal protein L8 AQLNIGNVLPVGTMPEGTIVCCLEEKPGDR IPI kda protein AAHVFFTDSCPDALFNELVK IPI kda protein ERPDLPPIQYEPVLCSR IPI Acidic leucine-rich nuclear phosphoprotein 32 family CPNLTYLNLSGNK

2 member E IPI Aconitate hydratase, DLGGIVLANACGPCIGQWDR IPI Actin, cytoplasmic 1 EKLCYVALDFEQEMATAASSSSLEK FRCPEALFQPSFLGMESCGIHETTFNSIMK IPI Actin-related protein 2 CGYAGSNFPEHIFPALVGRPIIR IPI Acyl-CoA dehydrogenase family member 9, GSNTCEVHFENTK IPI ADP/ATP translocase 1 YFAGNLASGGAAGATSLCFVYPLDFAR GVQFAPFSTCR IPI IPI Alkyldihydroxyacetonephosphate synthase, peroxisomal Alpha-actinin-4 IPDIVLWPTCHDDVVK YGSVAFPNFEQGVACLR ICDQWDALGSLTHSR KTFTAWCNSHLR IPI Alpha-soluble NSF attachment protein IEEACEIYAR IPI IPI Aminoacyl trna synthase complex-interacting multifunctional protein 2 ANP32A protein FSIQTMCPIEGEGNIAR SLDLFNCEVTNLNDYR VSGGLEVLAEKCPNLTHLNLSGNK IPI AP-1 complex subunit beta-1 isoform c CVSTLLDLIQTK IPEQSVLLLHACAHNPTGVDPRPEQWK IPI IPI IPI IPI Aspartate aminotransferase, ATP-dependent RNA helicase A Bifunctional aminoacyl-trna synthetase Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NLDKEYLPIGGLAEFCK TCGFDFTGAVEDISK VGAFTMVCK LQISHEAAACITGLR VRPGFCFHLCSR SLCIPFKPLCELQPGAK YNVYPTYDFACPIVDSIEGVTHALR ICNAVSPDKDVDGFHVINVGR IPI Carbonyl reductase [NADPH] 1 DVCTELLPLIKPQGR IPI Cathepsin D EGCEAIVDTGTSLMVGPVDEVR IPI CD151 antigen VEGGCITKLETFIQEHLR IPI CDGSH iron-sulfur domain-containing protein 1 KFPFCDGAHTK IPI Chloride intracellular channel protein 1 LHIVQVVCK IPI Coatomer subunit epsilon NAFYIGSYQQCINEAQR IPI Coatomer subunit gamma ELAPAVSVLQLFCSSPK IPI IPI IPI Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, Complement component 1 Q subcomponent-binding protein, Complement decay-accelerating factor ERICSEEER ALVLDCHYPEDEVGQEDEAESDIFSIR IPGEKDSVICLK QPYITQNYFPVGTVVEYECRPGYR TSFPEDTVITYKCEESFVK

3 IPI C-type mannose receptor 2 DCSIALPYVCK IPI D-3-phosphoglycerate dehydrogenase ALVDHENVISCPHLGASTK IPI Dihydrolipoyl dehydrogenase NETLGGTCLNVGCIPSK IPI DNA topoisomerase 1 AGNEKEEGETADTVGCCSLR CDFTQMSQYFK IPI DNA-(apurinic or apyrimidinic site) lyase ICSWNVDGLR IPI Electron transfer flavoprotein subunit alpha, LGGEVSCLVAGTK QFNYTHICAGASAFGK TIYAGNALCTVKCDEK IPI Elongation factor 2 CLYASVLTAQPR YVEPIEDVPCGNIVGLVGVDQFLVK IPI elongation factor Tu, precursor GEETPVIVGSALCALEGRDPELGLK KGDECELLGHSK IPI Endoplasmic reticulum resident protein 44 VANILHDDCAFLSAFGDVSKPER KLTAGEACAQGLVTEVFPDSTFQK IPI enoyl-coa delta isomerase 2, isoform 1 LHAVNAEECNVLQGR WLSDECTNAVVNFLSR IPI Enoyl-CoA hydratase, ALNALCDGLIDELNQALK IPI Epiplakin LLDAQLATGGLVCPAR YLEGTSCIAGVLVPAK IPI Eukaryotic translation initiation factor 2 subunit 3 SCGSSTPDEFPTDIPGTK IPI Folate receptor alpha CIQMWFDPAQGNPNEEVAR TELLNVCMNAK IPI Galectin-1 DSNNLCLHFNPR IPI glucosidase 2 subunit beta isoform 2 YEQGTGCWQGPNR IPI GTP-binding nuclear protein Ran VCENIPIVLCGNK IPI Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 KACADATLSQITNNIDPVGR LFVSGACDASAK IPI Guanine nucleotide-binding protein subunit beta-2-like 1 FSPNSSNPIIVSCGWDK IPI H/ACA ribonucleoprotein complex subunit 4 TTHYTPLACGSNPLKR IPI Heat shock protein HSP 90-beta LVSSPCCIVTSTYGWTANMER IPI IPI Hepatoma-derived growth factor Heterogeneous nuclear ribonucleoprotein L CGDLVFAK KSCVEEPEPEPEAAEGDGDKK ASLNGADIYSGCCTLK VFNVFCLYGNVEK IPI Inorganic pyrophosphatase GISCMNTTLSESPFK IPI Isocitrate dehydrogenase DLAGCIHGLSNVK NILGGTVFREPIICK IPI Isoform 1 of protein epsilon LICCDILDVLDK KLGNNCVFAPADVTSEKDVQTALALAK IPI Isoform 1 of 3-hydroxyacyl-CoA dehydrogenase type-2 VCNFLASQVPFPSR VDVAVNCAGIAVASK IPI Isoform 1 of 3-hydroxyisobutyryl-CoA hydrolase, KGCTGVITLNRPK

4 IPI Isoform 1 of 60S ribosomal protein L12 EILGTAQSVGCNVDGR IPI Isoform 1 of Alpha-actinin-1 DGLGFCALIHR ICDQWDNLGALTQK IPI Isoform 1 of Annexin A2 GLGTDEDSLIEIICSR IPI Isoform 1 of Carbamoyl-phosphate synthase [ammonia], MCHPSIEGFTPR TSACFEPSLDYMVTK IPI Isoform 1 of Coatomer subunit alpha VQVPNCDEIFYAGTGNLLLR IPI Isoform 1 of Core histone macro-h2a.1 FVIHCNSPVWGADKCEELLEK IPI IPI Isoform 1 of Dehydrogenase/reductase SDR family member 7 Isoform 1 of DNA-dependent protein kinase catalytic subunit SLCMDTSLDVYR ELLNPVVEFVSHPSTTCR GFPPSASLCLLDLVK IIANALSSEPACLAEIEEDKAR KNILEESLCELVAK LACDVDQVTR LAGANPAVITCDELLLGHEK QCLPSLDLSCK SQGCSEQVLTVLK IPI Isoform 1 of Electron transfer flavoprotein subunit beta EVIAVSCGPAQCQETIR IPI Isoform 1 of Far upstream element-binding protein 3 IQIASESSGIPERPCVLTGTPESIEQAK IPI Isoform 1 of Heterogeneous nuclear ribonucleoprotein R GFCFLEYEDHK IPI Isoform 1 of Isocitrate dehydrogenase [NAD] subunit alpha, CSDFTEEICR TFDLYANVRPCVSIEGYK IPI Isoform 1 of L-lactate dehydrogenase A chain LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK IPI Isoform 1 of Mitochondrial dicarboxylate carrier GEYQGVFHCAVETAK IPI Isoform 1 of Myb-binding protein 1A GNTAEGCVHETQEK IFTHHLCR IPI Isoform 1 of Oxidoreductase HTATIP2 YSVFRPGVLLCDR IPI Isoform 1 of Polypyrimidine tract-binding protein 1 LSLDGQNIYNACCTLR IPI Isoform 1 of Pre-mRNA-splicing factor 38A VCDIILPR IPI Isoform 1 of Prolyl 4-hydroxylase subunit alpha-1 HAACPVLVGNK EADNVKDKLCSK IPI Isoform 1 of Protein canopy homolog 2 RTDLCDHALHISHDEL IPI IPI Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 Isoform 1 of Replication protein A 32 kda subunit SEAHLTELLEEICDRMK FLEVIKPFCVILPEIQKPER ACPRPEGLNFQDLK AQHIVPCTISQLLSATLVDEVFR IPI Isoform 1 of RNA-binding protein 4 LHVGNISPTCTNK IPI Isoform 1 of Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SLPSVETLGCTSVICSDK IPI Isoform 1 of Sister chromatid cohesion protein PDS5 LLVACCLADIFR

5 homolog A IPI Isoform 1 of Transcription elongation factor A protein 1 NCTYTQVQTR TGGTQTDLFTCGK IPI Isoform 1 of Triosephosphate isomerase IAVAAQNCYK IPI IPI Isoform 1 of U5 small nuclear ribonucleoprotein 200 kda helicase Isoform 1 of Vesicle-associated membrane protein-associated protein A DILCGAADEVLAVLK CVFEMPNENDKLNDMEPSK IPI Isoform 1 of Vinculin CDRVDQLTAQLADLAAR IPI Isoform 2 of Acidic leucine-rich nuclear phosphoprotein 32 family member B KLECLK IPI Isoform 2 of Adenylate kinase 2, LAENFCVCHLATGDMLR IPI Isoform 2 of Apolipoprotein A-I-binding protein RPNKPLFTALVTQCQK IPI Isoform 2 of Bromodomain adjacent to zinc finger domain protein 1A SLDLDSCTLSEILR IPI Isoform 2 of Cellular nucleic acid-binding protein CYSCGEFGHIQK GQCDLELINVCNENSLFK IPI Isoform 2 of Clathrin heavy chain 1 IHEGCEEPATHNALAK LPVVIGGLLDVDCSEDVIK IPI Isoform 2 of Enoyl-CoA delta isomerase 1, GVILTSDRPGVFSAGLDLTEMCGR IPI Isoform 2 of F-actin-capping protein subunit beta QMEKDETVSDCSPHIANIGR IPI IPI IPI IPI Isoform 2 of Filamin-A Isoform 2 of Heterogeneous nuclear ribonucleoprotein A1 Isoform 2 of Heterogeneous nuclear ribonucleoprotein M Isoform 2 of Mitochondrial inner membrane protein OXA1L CSGPGLER VQVQDNEGCPVEALVK SHFEQWGTLTDCVVMRDPNTKR YHTVNGHNCEVRK DKFNECGHVLYADIK KACQIFVR CLIFPLIVTGQR IPI Isoform 2 of NADH-cytochrome b5 reductase 3 AIMKDPDDHTVCHLLFANQTEK IPI Isoform 2 of Nuclear autoantigenic sperm protein KPTDGASSSNCVTDISHLVR IPI Isoform 2 of Proteasome subunit alpha type-3 CKDGVVFGVEK IPI Isoform 2 of Pyruvate dehydrogenase E1 component subunit beta, EGVECEVINMR IPI Isoform 2 of Syntenin-1 NGLLTEHNICEINGQNVIGLK IPI Isoform 2 of Transportin-1 SECLNNIGDSSPLIR IPI Isoform 2 of U1 small nuclear ribonucleoprotein 70 kda HHNQPYCGIAPYIR IPI Isoform 2 of Valacyclovir hydrolase VQCPALIVHGEKDPLVPR IPI Isoform 2 of Very long-chain specific acyl-coa dehydrogenase, ELGAFGLQVPSELGGVGLCNTQYAR LASGETVAAFCLTEPSSGSDAASIR IPI Isoform 3 of Beta-catenin-like protein 1 VGTTEKEHEEHVCSILASLLR IPI Isoform 3 of Exportin-2 KICAVGITK NLFEDQNTLTSICEK

6 IPI Isoform 3 of Heterogeneous nuclear ribonucleoprotein D0 FGEVVDCTLKLDPITGR GFCFITFKEEEPVKK IPI Isoform 3 of Heterogeneous nuclear ribonucleoprotein K LFQECCPHSTDR CDNFTSSWR CRPDQLTGLSLLPLSEK CVEDPETGLCLLPLTDK IPI Isoform 3 of Plectin CVEDPETGLR EYGSCSHHYQQLLQSLEQGAQEESR LLEAQACTGGIIDPSTGERFPVTDAVNK TLLQGSGCLAGIYLEDTKEK IPI Isoform 3 of Reticulon-3 SCSSSCAVHDLIFWR IPI Isoform 3 of Transformer-2 protein homolog beta ANPDPNCCLGVFGLSLYTTER IPI Isoform 3 of Transmembrane emp24 domain-containing protein 4 CFIEEIPDETMVIGNYR IPI Isoform 4 of Hexokinase-1 AILQQLGLNSTCDDSILVK IPI Isoform 4 of LIM domain and actin-binding protein 1 IYCKPHFNQLFK LLANQQVFHISCFR IPI Isoform A of Prelamin-A/C SVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLR IPI Isoform ASF-1 of Serine/arginine-rich splicing factor 1 EAGDVCYADVYR IPI Isoform B of AP-2 complex subunit alpha-1 LVECLETVLNK IPI IPI IPI IPI IPI Isoform B of Phosphate carrier protein, Isoform B1 of Heterogeneous nuclear ribonucleoproteins A2/B1 Isoform Cytoplasmic+peroxisomal of Peroxiredoxin-5, Isoform Long of Heterogeneous nuclear ribonucleoprotein U Isoform M2 of Pyruvate kinase isozymes M1/M2 GWAPTFLGYSMQGLCK YYALCGFGGVLSCGLTHTAVVPLDLVK LTDCVVMRDPASKR KGVLFGVPGAFTPGCSK GNFTLPEVAECFDEITYVELQKEEAQK KMCLFAGFQR AEGSDVANAVLDGADCIMLSGETAK AGKPVICATQMLESMIK CCSGAIIVLTK CDENILWLDYK IPI Isoform Short of Glucose-6-phosphate 1-dehydrogenase DNIACVILTFK IPI Isoform SM-B of Small nuclear ribonucleoprotein-associated proteins B and B' HMNLILCDCDEFRK IPI Isoform Smooth muscle of Myosin light polypeptide 6 MTEEEVEMLVAGHEDSNGCINYEELVR IPI IPI Isoleucyl-tRNA synthetase, Junction adhesion molecule IHFVPGWDCHGLPIEIK SCQTALVEILDVIVR AVLTCSEQDGSPPSEYTWFK LSCAYSGFSSPR IPI Lamin-B1 CQSLTEDLEFRK IPI Leucine-rich repeat-containing protein 59 LTTLPSDFCGLTHLVK VAGDCLDEKQCK

7 VTELQQQPLCTSVNTIYDNAVQGLR IPI L-lactate dehydrogenase B chain VIGSGCNLDSAR IPI MACRO domain-containing protein 1 SCYLSSLDLLLEHR GCDVVVIPAGVPR IPI Malate dehydrogenase, GYLGPEQLPDCLKGCDVVVIPAGVPR SQETECTYFSTPLLLGK IPI maleylacetoacetate isomerase isoform 2 LLVLEAFQVSHPCR IPI Matrin-3 LCSLFYTNEEVAK IPI Mesencephalic astrocyte-derived neurotrophic factor DSQICELKYDK LCYYIGATDDAATK IPI Methionyl-tRNA synthetase, cytoplasmic SCPVVQSSQHLFLDLPK IPI Methyltransferase-like protein 7A LSLLEVGCGTGANFK IPI Microsomal glutathione S-transferase 1 KVFANPEDCVAFGKGENAK IPI Mitochondrial carrier homolog 2 LCSGVLGTVVHGK IPI MKI67 FHA domain-interacting nucleolar phosphoprotein TVDSQGPTPVCTPTFLER IPI mrna export factor CWEVQDSGQTIPK IPI neural cell adhesion molecule L1 isoform 3 precursor GALILSNVQPSDTMVTQCEAR IPI Neuroblast differentiation-associated protein AHNAK SSGCDVNLPGVNVK IPI Non-POU domain-containing octamer-binding protein CSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEK FACHSASLTVR IPI Nucleolar protein 56 IDCFSEVPTSVFGEK IPI p180/ribosome receptor LTAEFEEAQTSACR IPI Palmitoyl-protein thioesterase 1 CPGESSHICDFIR CPSPPMINLISVGGQHQGVFGLPR IPI Peptidyl-prolyl cis-trans isomerase B DKPLKDVIIADCGK IPI Peptidyl-prolyl cis-trans isomerase F, VIPSFMCQAGDFTNHNGTGGK IPI Peroxiredoxin-1 HGEVCPAGWKPGSDTIKPDVQK IPI Peroxiredoxin-4 HGEVCPAGWKPGSETIIPDPAGK IPI Peroxiredoxin-6 DINAYNCEEPTEK IPI Peroxisomal multifunctional enzyme type 2 KICDFENASKPQSIQESTGSIIEVLSK SNIHCNTIAPNAGSR IPI PHD finger-like domain-containing protein 5A ICDECNYGSYQGR IPI Phosphoglycerate kinase 1 DVLFLKDCVGPEVEK IPI Poly [ADP-ribose] polymerase 1 SDAYYCTGDVTAWTK IPI Poly(rC)-binding protein 1 INISEGNCPER IPI poly(rc)-binding protein 2 isoform c AITIAGIPQSIIECVK IPI Polypeptide N-acetylgalactosaminyltransferase 2 VWQCGGSLEIIPCSR AAQDLCEEALR IPI Pre-mRNA-processing factor 6 CPHSTPLWLLLSR HGELWCAVSK IPI Profilin-1 CYEMASHLR IPI Proliferating cell nuclear antigen LMDLDVEQLGIPEQEYSCVVK

8 IPI Proteasome activator complex subunit 1 VDVFREDLCTK IPI Proteasome subunit alpha type-4 ATCIGNNSAAAVSMLK IPI Proteasome subunit alpha type-6 ITENIGCVMTGMTADSR IPI Protein NipSnap homolog 2 ICQEVLPK IPI Putative 40S ribosomal protein S26-like 1 LHYCVSCAIHSK IPI Putative ATP-dependent RNA helicase DHX30 CQSGFAYHLFPR IPI IPI Putative pre-mrna-splicing factor ATP-dependent RNA helicase DHX15 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, FQIYFDNCPLLTIPGR LPCIFICENNR IPI Ran GTPase-activating protein 1 ALAPLLLAFVTKPNSALESCSFAR ILAAALTECHRK IPI Ras GTPase-activating-like protein IQGAP1 QIPAITCIQSQWR IPI Ras homolog gene family, member C HFCPNVPIILVGNK IPI Ras-related protein Rab-14 FMADCPHTIGVEFGTR SCLLHQFTEK IPI Ras-related protein Rab-2A SCLLLQFTDKR IPI Ribosomal protein L3, isoform CRA_b TVFAEHISDECK IPI RNA-binding region (RNP1, RRM) containing 2, isoform CRA_b CPSIAAAIAAVNALHGR IPI RPL14 protein (Fragment) CMQLTDFILK IPI Serine hydroxymethyltransferase AALEALGSCLNNK IPI IPI Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serpin B6 ICGDIHGQYYDLLR FCADHPFLFFIQHSK SCDFLSSFR IPI serum paraoxonase/arylesterase 2 isoform 2 EVESVDLPHCHLIK IPI Small nuclear ribonucleoprotein Sm D2 HCNMVLENVK IPI Splicing factor 3A subunit 3 CLGIPNTAHFANVTQIEDAVSLWAK IPI Splicing factor 3B subunit 1 VKPYLPQICGTVLWR VQENCIDLVGR IPI SRA stem-loop-interacting RNA-binding protein, CILPFDKETGFHR IPI Sterol O-acyltransferase 1 SASLDNGGCALTTFSVLEGEK IPI Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating CTVIGGSGFLGQHMVEQLLAR IPI Structural maintenance of chromosomes protein 1A AESLIGVYPEQGDCVISK IPI Succinate dehydrogenase [ubiquinone] flavoprotein subunit, AAFGLSEAGFNTACVTK IPI sulfatase-modifying factor 2 isoform c precursor CAADAGRPPGEL IPI Surfeit 4 LCLISTFLEDGIR IPI T-complex protein 1 subunit beta HGINCFINR SLHDALCVLAQTVK

9 IPI T-complex protein 1 subunit eta QLCDNAGFDATNILNK IPI T-complex protein 1 subunit theta IAVYSCPFDGMITETK QITSYGETCPGLEQYAIK IPI T-complex protein 1 subunit zeta NAIDDGCVVPGAGAVEVAMAEALIK IPI thioredoxin-dependent peroxide reductase, isoform b AFQYVETHGEVCPANWTPDSPTIKPSPAASK IPI Transaldolase ALAGCDFLTISPK IPI Transcription elongation factor B polypeptide 2 TLGECGFTSQTARPQAPATVGLAFR IPI Translational activator of cytochrome c oxidase 1 EGGPNPEHNSNLANILEVCR ALMGLYHGQVLCK IPI Trifunctional enzyme subunit alpha, EVEAVIPDHCIFASNTSALPISEIAAVSK QFTPCQLLADHANSPNKK TGIEQGSDAGYLCESQK IPI Trifunctional enzyme subunit beta, FNNWGGSLSLGHPFGATGCR IPI TUBA1B protein SIQFVDWCPTGFK IPI Tubulin alpha-1a chain TIQFVDWCPTGFK IPI Tubulin beta-2c chain MREIVHLQAGQCGNQIGAK IPI Uroporphyrinogen decarboxylase AAQDFFSTCR IPI Vacuolar protein sorting-associated protein 35 AVSTCAHLFWSGR IPI Valyl-tRNA synthetase LVNWSCTLNSAISDIEVDKK