Additional File 1 (Table S1): Description and primer sequences of 80 candidate genes tested as potential synaptic plasticity formation genes in qrt-pcr array. Abbreviations: LTP: long-term potentiation, LTD: long-term depression, IEG: immediate early response genes, ECM: extracellular matrix molecules Gene Synaptic Plasticity General Function Name Function Forward Primer Sequence (5-3 ) Reverse Primer Sequence (5-3 ) Adam10 Metallopeptidase, ECM, TCCCAAGCCCAACTTTACAGA TGCACATTGCCCATTAATGC Adcy1 Adenylate cyclase LTP TGACAAGCGAAGGGCATTG TGGTAGAGAATGACGAACGGTTT Adcy8 Adenylate cyclase LTP GCCCTGGCTGACTTCTCTCTT TGTTGAACGAATGCTTGTTGATC Adora1 Adenosine receptor AAGATCCCTCTCCGGTACAA TACCACAAGGGAGAGAATCCA Akt1 Akt kinase Creb signaling CCTTACAGCCCTCAAGTACTCATTC GGCGTACTCCATGACAAAGCA Arc Actin binding IEG, Postsynaptic GGAGAACGACACCAGGTCTCA GGTGGTACCCCTTCCAGACA Bdnf Growth factor IEG, LTP CAGGAGCGTGACAACAA TCACCTGGTGGAACTCA Braf MAP kinase kinase LTP, LTD CAGGACGGAGAGAAGAAACCAA TCCTCTCCAGTAAGCCAGGAAA Cacna1g Voltage gated calcium channel LTP, LTD TCAGCTGCCTGTCAACTCTCA GGCCAAGCGCTTCTTTCTG Cacna1i Voltage gated calcium channel LTP, LTD CGGCGCCTGGAAAAGAA GGTGCACATGGAGTGGATGA Calm1 binding Creb signaling, LTP CGTGAGGCATTCCGAGTCTT TGACGTGGCGCAGTTCTG Calm2 binding LTP GCTGCAGGACATGATCAATGA GGAATTCAGGGAAGTCGATTGT Calm3 binding LTP AGGATGGGAATGGCTACATCAG CCCCCAGGTTCGTCATGAC Calm4 binding LTP AAGGAGCAGGTGGCTGAGTTAC CGGCCATCCTTATTCTTGTCA Camk2a Calmodulin-dependent IEG, LTP, protein kinase GCATCTGCCGCTTGTTGAA CTCGGAGATGCTGTCATGGA Camk2b Calmodulin-dependent IEG, LTP, Post protein kinase synaptic ACCACAGAGCAGCTCATCGA GGCCTGGGTCACAGATTTTC Camk2g Calmodulin-dependent IEG, LTP GCCAAGGTTGGTGAGCTCAA TTGCCTGCACCCAGTTCTG
protein kinase Camk4 Calmodulin-dependent IEG, LTP, protein kinase GAACCTCGTCCCGGATTACTG TCGAAGAAATCGCTCAGAGGAT Cbp Creb signaling GGGTGGGATCTCAGCAATGT CAGGTTTGTGTGCCGATTGT Ccl2 Chemokine LTP CTCAGCCAGATGCAGTTAATGC AGCCGACTCATTGGGATCAT Cebpb Creb signaling GAGCGCGCCATATTCAG AGAGGTCGGAAAGGAAGT Crem Creb signaling CTGCTGCCACAGGTGACATG CACCTTGTGGCAAAGCAGTAGT Creb1 Creb signaling, LTP, IEG GTGGAGATGCTGCTGTAA ATGGATACCTGGGCTAATG Creb2 Creb signaling, LTD, IEG AGTTGTTATGGCGTCCTC CTGCTTCCCTGTTCTTCA Cxcr4 Chemokine LTP CCTTGCCCCAAGTCACATG GGAGCTCGGATCTGGTAAGTTG Dbh Dopamine betamonooxygenase, LTP CAGGATCCTCCCGGTTTCTC CGCCGGCCTTGTATATTCC oxidoreductase Dhcr24 Oxidoreductase LTP TCTGCCTGTGTTGCCTGAAC ATGCCGGTGCCCATGAT Dlg4 Scaffold protein, binding CCCCAACATGGACTGTCTCTGT GGGCGTGTCTTCATCTTGGT Egfr Growth factor IEG TCCGCTGTGGCTTGCATT CGTTGCAAGAAGGCGTCTTC Egr1 IEG CGAGCGAACAACCCTACGA CGTTATTCAGAGCGATGTCAGAA Fas Transmembrane apoptosis signaling LTD TGCACCTCGTGTGGACTTGA CATTTGGTGTTGCTGGTTCGT receptor Fos Creb signaling, IEG CATGGGCTCCCCTGTCAAC TGGCACTAGAGACGGACAGATC Fosb Creb signaling, IEG CGTCGGAGGGAGCTGACA GCTCTGCCTTTTCCTCTTCGA
Gabra5 Gapdh Gria1 Gria2 Gria3 Grin1 Grin2a Grin2b GABA-A receptor Protein and microtubule binding receptor receptor receptor receptor receptor receptor LTP CATGCGCCTGACGATCTCT TCCATCGGGAAGTCCTCAAG Housekeeping gene AATGTATCCGTTGTGGATCTGACAT CTCGGCCGCCTGCTT LTP, LTD, CAGGTGCGCTTCGAAGGTT GTCCGGCGCCCTTTCT LTP,LTD ACCCCGGAAGATTGGGTACT CCAGACGTGTCATTTCCTGATG LTP, LTD, LTP, Postsynaptic LTP,, Creb signaling, LTP,, Creb signaling, LTP, Postsynaptic CTTGTCTATGGAAGAGCTGATA CACAGGAGCGGGTAAACAACA GCATCTGCCACAACGAGAAG CTGTCCGCCTAGAGGTTTGG GAGATTCCCAGGCTCATAAA TGAGTAGCTCGCCCATCATTC CCCGCCATGTTATCGATGTC TGCGCTGGGCTTCATCTT Grin2c receptor CTAGGAAGAACGGGCAGGAA AGAGAACCTCCCCCTGCTATTC Grin2d receptor LTP GTCTGCACAGGTACTTCATGAACAT GGTTCACCAGAAAGCCATCCT Grm1 Metabotropic LTD, LTP, glutamate receptor TTGGAAGTGATGGATGGG TGACCTCTGGAGACTGAA Metabotropic Grm5 glutamate receptor LTD, LTP CAAGACTTGCAACAGTTCTC GGAGTCCATAAGCCATAGAATA Heme oxygenase, Hmox1 immune response LTP GCTGACAGAGGAACACAA TGCAGAGGTAGTATCTTGAAC Hras GTPase LTP, LTD GGTGGAGAACCCAAGAAG CGTTAACCGCCATCTCC Il-6 Cytokine LTP AGGGAGATCTTGGAAATGAGAAAA TCATCGCTGTTCATACAATCAGAA
Itpr1 Itpr2 Itpr3 Jun Junb transporter transporter transporter LTD GCAGAGGGATCTACGAATGGAT GTACAACGCAACGGTCATCAA LTD GGGCGACCAGCGCTATG CGATGTACTCCTGGTTCTTCCTGT A LTD AGAACGACCGCAGGTTTGTC GTTGGGTTTGGTGACCATGAT Creb signaling, IEG AATGGGCACATCACCACTACAC TGCTCGTCGGTCACGTTCT Creb signaling, IEG TGCGGACGGTTTTGTCAA GCGTCACGTGGTTCATCTTG Kras GTPase LTP, LTD TACGATAGAGGACTCCTACAG TTGCACTGTACTCCTCTTG Map2k1 MAP kinase LTD, Creb signaling GCAGCTCATGGTACATGCTTTC CCAGCCTGCGAAGTCTACCT Map2k2 MAP kinase LTD, Creb signaling GCAGCTCATGGTACATGCTTTC CCAGCCTGCGAAGTCTACCT Mapk1 Mapk3 MAP kinase MAP kinase LTP, LTD, Creb signaling LTP, LTD, Creb signaling GCATGGTTTGTTCTGCTTAT GCCCTCCAATCTGCTT TCAGGGTTCTCTGACAGTA GCAAGGCCAAAATCAC Mecp2 Creb signaling GGGTCTCATGGAGGAA GTTTGCCCTCTTTGTCT Mmp9 Metallopeptidase ECM, TCGAAGGCGACCTCAAGTG TTCGGTGTAGCTTTGGATCCA Neuron-neuron Ncam1 adhesion, neurite GACCAGAGAAGCAAGAGACTCTAG fasciculation and ATG CAGGGAGGACACACGAGCAT outgrowth Ngf Growth factor IEG ACTCTGAGGTGCATAGC TGGGACATTGCTATCTGT Ngfr Growth factor LTD GGGCCTTGTGGCCTATATTG GCGCCTTGTTTATTTTGTTTGC Nras GTPase LTP, LTD GGTCTGCGGAGTTTGAGATTTT CTCCAACCACCACCAGTTTGT Ntrk2 Neurotrophin receptor LTP TCCTGGTGGCCGTGAAGA GCTTCGCGATGAAAGTCCTT
Nurr1 IEG TGCCTTCTCCTGCATTGCT GTTCCTTGAGCCCGTGTCTCT Pick1 CAGCTGATGCCCTGGGTCTA CCGCTTTACCAACCCATCAT Plcb3 Phospholipase C LTP, LTD GCCTCCCGGAACACGTT TGGTTCACCTGCAGCTTCAG Plcb4 Phospholipase C LTD CCTGATGGATTTGGAGATATTG GCCCATTGCTCTCATTTG Prkaca Protein kinase A LTP TGGGACCCCCGAGTACTTG ACAGCTTTGTTGTAGCCTTTGCT Prkacb Protein kinase A LTP, Creb signaling GAACCCTCCCCCGAGTAATG GTTCCAAGGGTTTTTTTCCTTTC Prkca LTP, LTD CAAGTTTGCTGTTTTGTGGTTCA GCACCCGGACAAGAGAAAGTAA Prkcg LTP AGCAACTGGGCAAGTTTAAGGA GAGGCCTATGGCGATTTCC Raf1 MAP kinase kinase LTP, LTD ACATTGCCCGGCAGACA TCTGTGGATGATGTTCTTTGCAT Rps6ka1 MAP kinase Creb signaling CCCAACATCATCACCCTGAAA TCAGCTCTGTCACCAGGTATACG Sst Growth hormone inhibition LTP CCCAGACTCCGTCAGTTTCTG CTTGGCCAGTTCCTGTTTCC Syn1 Actin binding, ACGATGTGCGTGTCCAGAAG TCCCTGACACTGATGTCCTCAT Synpo Actin binding, CGCCAGTCACGGATGGA AAGGGCAGCGAGCCAATT Th Catecholamine biosynthesis LTP TGTTGGCTGACCGCACAT CCCAGAGATGCAAGTCCAATG Tnf Cytokine CCTCAGCCTCTTCTCATT GGAACTTCTCCTCCTTGT