RET SRC WEE1 JAK2 MAP2K1 PKMYT1 ERBB2 BMX MET PTK2 FGR MAPK3 MAP2K2 ABL1 MAP2K4 MAP2K6 MAP3K6 MAP3K5 CDK5 ALK PTK2 MAPK14 LCK HIPK2

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1 4 SYK MAPK9 6 SKMel28.Replicate.1 Kinome 4 MAPK9 DYRK2 SKMel28.Replicate.1 ActLoop MAP3K6 SKMel28.Replicate.1 PSP SRMS SKMel28.Replicate.1 NWK HIPK3 Not in PSP/NWK INKA SKMel28.Replicate Kinase Centric Counts Relative Score FER SYK EPHA3 ALPK3 0 AKT1 Kinase Centric AKT2 AKT3 Substrate Centric ADRBK1 ARAF 4 Equal Contribution Score 4 InKA Score SKMel28.Replicate

2 CAV1 MAP3K6 4 MPZL1 PDGFRA PRKACA PTPRA PXN STAT3 VCL SKMel28.Replicate.1

3 4 SKMel28.Replicate.2 Kinome 4 DYRK2 SKMel28.Replicate.2 ActLoop SKMel28.Replicate.2 PSP SRMS PDGFRA SKMel28.Replicate.2 NWK HIPK3 Not in PSP/NWK Relative Score INKA SKMel28.Replicate Score Kinase Centric Counts 0.1 AKT2 EPHA30 BCR ABL ADRBK1 Kinase Centric AKT1 AKT3 Equal Contribution Substrate Centric 3 4 InKA Score SKMel28.Replicate

4 SKMel28.Replicate.2 PRKACA PTPRA PDGFRA VCL MAP3K6 BCAR1 SYK 4 STAT3 PXN

5 4 H2228.Replicate.1 Kinome 4 H2228.Replicate.1 ActLoop MAP3K6 H2228.Replicate.1 PSP EPHA1 MAP2K7 FLT1 H2228.Replicate.1 NWK HIPK3 7 Not in PSP/NWK INKA H2228.Replicate Relative Score Score Kinase Centric Counts FGFR1 FER AURKA EPHA3 EPHA4 EPHB3 AKT2 0 TGFBR2SYK ALPK3 Kinase Centric ARAF ADRBK1 AKT1 AURKB AKT3 Equal Contribution Substrate Centric InKA Score H2228.Replicate

6 ABI1 ACTN1 AP2B1 BCAR1 CAV1 CBL CD46 CRK CTNNA1 CTNNA2 CTNND1 CTTN DOCK4 EML4 EPHA1 G6PD GAB1 GAB2 GPRC5A INPP5D INPPL1 IRS1 IRS2 ITGB1 ITGB4 MAP2K7 MAP3K6 4 MPZL1 MUC1 NAMPT NCK1 PAG1 PDGFRA PFN1 PIK3R1 PIK3R3 PRKACA PRKCE PTPN11 PTPRA PTPRE PTTG1IP PXN SDCBP SHC1 STAT3 VASP VCL H2228.Replicate.1

7 4 H2228.Replicate.2 Kinome 4 H2228.Replicate.2 ActLoop H2228.Replicate.2 PSP EPHA1 MAP2K7 H2228.Replicate.2 NWK HIPK3 7 Not in PSP/NWK INKA H2228.Replicate Relative Score Score Kinase Centric Counts EPHB3 ERBB4 AURKA AKT2 FRK ALPK3 Kinase Centric ARAF ADRBK1 AKT1 AURKB AKT3 Equal Contribution Substrate Centric InKA Score H2228.Replicate

8 ACTN1 ADRBK1 AP2B1 ARHGAP35 BCAR1 CAMK2A CAV1 CBL CD46 CTNND1 CTTN EML4 EPHA1 G6PD GAB1 GAB2 GPRC5A HSP90AA1 HSP90AA2P INPP5D INPPL1 IRS1 IRS2 ITGB1 ITGB4 MAP2K7 MAP3K6 4 MPZL1 MUC1 NAMPT NCK1 PAG1 PDGFRA PIK3R1 PIK3R3 PRKACA PRKCE PTPN11 PTPRA PTPRE PTTG1IP PXN SDCBP SHC1 STAT3 TNS3 VCL VIM H2228.Replicate.2

9 BCR 4 BTK K562.Replicate.1 Kinome 4 DDR1 HIPK3 K562.Replicate.1 ActLoop BCR ABL SYK K562.Replicate.1 PSP BTK NTRK1 FLT1 K562.Replicate.1 NWK DDR1 HIPK3 7 FAM20B Not in PSP/NWK Relative Score INKA K562.Replicate Score Kinase Centric Counts BTK 4 AKT3 ADRBK1 Kinase Centric AURKA SYK BCR ABL AKT2 0 PRKCB AKT1 ALPK3 BLK Equal Contribution Substrate Centric InKA Score K562.Replicate.1 BTK 4 SYK

10 ABI1 ACTN1 ARHGAP35 BCR BTK CBL CD46 CRK CTTN DOK1 DOK2 FCGR2A FCGR2C FYB G6PD GAB1 GAB2 INPPL1 MAP3K6 4 MPZL1 NCK1 NTRK1 NTRK2 PDGFRA PFN1 PIK3R2 PLCG1 PRKACA PRKCD PTPRA PTTG1IP SH2D2A SHC1 STAT5A STAT5B SYK WAS K562.Replicate.1

11 BCR 4 BTK K562.Replicate.2 Kinome 4 DDR1 K562.Replicate.2 ActLoop BCR ABL SYK K562.Replicate.2 PSP BTK NTRK1 FLT1 K562.Replicate.2 NWK DDR1 HIPK3 7 TRIM28 Not in PSP/NWK Relative Score INKA K562.Replicate Score Kinase Centric Counts BTK AKT3 4 ADRBK1 PRKCD Kinase Centric 0 AURKA SYK BCR ABL AKT2 FER PRKCB AKT1 ALPK3 BLK Equal Contribution Substrate Centric InKA Score K562.Replicate.2 BTK

12 ABI1 ACTN1 ARHGAP35 BCR BTK CBL CD46 CRK CTTN DOK1 DOK2 FCGR2A FCGR2C G6PD GAB1 GAB2 INPPL1 MPZL1 NCK1 NTRK1 NTRK2 PDGFRA PLCG1 PPP1CA PRKACA PRKCD PTPRA PTTG1IP SH2D2A SHC1 STAT5A STAT5B WAS K562.Replicate.2

13 NRK FRK MINK1 ROR1 HCC827ER3.Replicate.1 Kinome TYRO3 MERTK JAK1 4 2 HCC827ER3.Replicate.1 ActLoop HCC827ER3.Replicate.1 PSP PRKCE EPHB2 EPHB1 ERBB4 EPHA4 ADRBK1 ERBB3 HCC827ER3.Replicate.1 NWK ROR1 TYRO3 GAK ALPK3 BMP2K BMPR2 Not in PSP/NWK Relative Score INKA HCC827ER3.Replicate Score Kinase Centric Counts 0.1 FRK ALPK3 ERBB4 EPHB2 AKT2 JAK1 CDC42BPB EPHA4 CSNK1A1 EPHA5 EPHA3 ERBB3 FER EPHB3 TGFBR2 0MELK4 PRKCA ADRBK1 PRKCI AKT3 MERTK LMTK2 AKT1 ARAF AURKA Kinase Centric Equal Contribution Substrate Centric 47 EPHB2 FRK ERBB4 InKA Score HCC827ER3.Replicate

14 ABI1 ABI2 ACP1 ACTN1 ADRBK1 APP ARHGAP35 ARHGAP5 BCAR1 BCR CAMK2A CAV1 CBL CBLB CCDC88A CD46 CDK4 CHN2 COPS5 CRK CRKL CTNND1 CTTN DAG1 DLG1 EFNB1 EFNB2 EMD EPB41 EPHB2 EPN2 EPS8 IP* ERBB3 ERBB4 ERRFI1 FRK G6PD GAB1 GAB2 GIT1 GJA1 GPRC5A HLA A INPPL1 IRS2 ITCH ITGB4 ITGB5 LAT2 LRP6 MPZL1 OCLN OSMR PAG1 PBK PFN1 PIK3R2 PKM PLCG1 PPP1R9A PRKCD PRKCE PTPN11 PTPN6 PTPRA PTTG1IP PXN RAB5A RAC1 RGS3 RIPK1 SDCBP SHC1 SPRY2 STAM STAM2 STAT1 STK11 TJP1 TNS3 TP53BP2 TYRO3 USP6NL VCL VIM WASL YAP1 ZDHHC8 HCC827ER3.Replicate.1

15 NRK FRK ROR1 MINK1 EPHB2 PRKCD HCC827ER3.Replicate.2 Kinome MAPK8 0 JAK1 2 HCC827ER3.Replicate.2 ActLoop HCC827ER3.Replicate.2 PSP PRKCE EPHB2 ERBB4 EPHB1 EPHA4 ADRBK1 HCC827ER3.Replicate.2 NWK ROR1 TYRO3 GAK BMPR2 PKN2 ALPK3 BMP2K FAM20B Not in PSP/NWK Relative Score INKA HCC827ER3.Replicate Score Kinase Centric Counts 0.1 EPHB2 ALPK3 FRK ERBB4 AKT2 CSNK1A1 CDC42BPB EPHA3 EPHA4 EPHB1 JAK1 4 ERBB3 EPHB3 FER MERTK MELK LMTK2 PRKCA ADRBK1 PRKCI AKT3 TGFBR2 0 EPHA5 AKT1 ARAF AURKA Kinase Centric Equal Contribution Substrate Centric 49 EPHB2 FRK ERBB4 InKA Score HCC827ER3.Replicate

16 ABI1 ABI2 ACP1 ACTN1 ADRBK1 APP ARHGAP35 ARHGAP5 BCAR1 BCR CAMK2A CAV1 CBL CBLB CCDC88A CD46 CHN2 COPS5 CRKL CTNND1 CTTN DAG1 DLG1 DLG3 EFNB1 EFNB2 EMD EPB41 EPHB2 EPN2 EPS8 IP* ERBB3 ERBB4 ERRFI1 FRK G6PD GAB1 GAB2 GIT1 GJA1 GPRC5A HGS HLA A HSP90AA1 HSP90AA2P HSP90AB3P INPPL1 IRS2 ITCH ITGB4 ITGB5 JUP LAT2 MPZL1 NOTCH1 OCLN OSMR PAG1 PBK PFN1 PIK3R2 PKM PLCG1 PRKCD PRKCE PTPN11 PTPN6 PTPRA PTTG1IP PXN RAB5A RAC1 RASA1 RIPK1 SDCBP SGK223* SHC1 SPRY2 STAM STAT1 STAT3 STK11 TJP1 TNS3 TYRO3 USP6NL VCL VIM WASL YAP1 HCC827ER3.Replicate.2

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