Global List of Validated Bioanalytical Assays

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1 Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your business development representative or via

2 Assays Under Development Compound Name Technique Species/Matrix 1-AMN; 2-AMN; 3-ABP; 4-ABP LC-MS/MS Human Urine Aprepitant LC-MS/MS Human Plasma Fluoxetine; Duloxetine; Paroxetine; Sertraline LC-MS/MS Human Plasma Nornicotine; Norcotinine; Nicotine-N'-oxide; Cotinine-N-oxide; LC-MS/MS Human Urine 4-Hydroxy-4-(3-pyridyl)-butanoic acid Octreotide LC-MS/MS Human Plasma o-toluidine LC-MS/MS Human Urine Propylene Glycol LC-MS/MS Human Plasma 1-Hydroxypyrene (1-OHP) LC-MS/MS Human Urine pg/ml N/A 1; 2-Dihydroxybutyl Mercapturic Acid LC-MS/MS Human Urine ng/ml N/A (DHBMA) 2-Pralidoxime (2-PAM) LC-MS/MS Human Plasma ng/ml 3-Hydroxyropylmercapturic Acid LC-MS/MS Human Urine ng/ml N/A (3-HPMA) 5-Fluorocytosine LC-MS/MS Human Plasma ug/ml 5-Fluorouracil LC-MS/MS Human Plasma ng/ml 6-Beta Naltrexol LC-MS/MS Human Plasma pg/ml 6-Mercaptopurine (6-MP) LC-MS/MS Human Plasma ng/ml 8-iso-Prostaglandin F 2α (Type III) LC-MS/MS Human Urine pg/ml N/A 8-iso-Prostaglandin F 2α (Type IV) LC-MS/MS Human Urine pg/ml N/A 11-Dehydro Thromboxane B 2 LC-MS/MS Human Urine pg/ml N/A 17-Deactylnorgestimate; Levonorgestrel LC-MS/MS Human Plasma pg/ml; pg/ml Abacavir; Zidovudine LC-MS/MS Human Plasma ng/ml; ng/ml Abacavir; Zidovudine; Lamivudine LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml Acetamidophenol LC-MS/MS Human Plasma ug/ml, Acetaminophen LC-MS/MS Human Plasma ng/ml, Lithium Acetyl Salicylic Acid (ASA) LC-MS/MS Human Plasma ug/ml Albuterol LC-MS/MS Human Plasma pg/ml K 2 Alendronate LC-MS/MS Human Urine ng/ml N/A Alendronate LC-MS/MS Human Serum ng/ml N/A Alendronate LC-MS/MS Human Plasma pg/ml Allopurinol; Oxypurinol LC-MS/MS Human Plasma ug/ml Alprazolam; Alpha-Hydroxyalprazolam LC-MS/MS Human Plasma ng/ml; ng/ml K 3 Amiodarone; Desethylamiodarone LC-MS/MS Human Plasma ng/ml; ng/ml Amlodipine LC-MS/MS Human Serum pg/ml N/A Amlodipine LC-MS/MS Human Plasma pg/ml Global List of Validated Bioanalytical Assays Q

3 Amoxicillin LC-MS/MS Human Plasma ug/ml Amphetamine D/L LC-MS/MS Human Plasma ng/ml Anastrazole LC-MS/MS Human Plasma ng/ml K 3, Lithium Aprepitant LC-MS/MS Human Plasma ng/ml Atenolol LC-MS/MS Human Plasma ng/ml Atomoxetine LC-MS/MS Human Plasma ng/ml Atorvastatin; Parahydroxy Atorvastatin; Orthohydroxy Atorvastatin LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml K 2 and K 3 Atropine LC-MS/MS Human Plasma ng/ml Baclofen LC-MS/MS Human Plasma ng/ml Baclofen LC-MS/MS Mouse Plasma ng/ml Bicalutamide LC-MS/MS Human Plasma ng/ml K 2 and K 3 Buprenorphine LC-MS/MS Human Plasma pg/ml Buprenorphine LC-MS/MS Human Plasma pg/ml Buprenorphine; Norbuprenorphine LC-MS/MS Human Plasma pg/ml; pg/ml Sodium Buprenorphine; Norbuprenorphine LC-MS/MS Human Plasma pg/ml; pg/ml Bupropion LC-MS/MS Human Plasma ng/ml Bupropion; Hydroxybupropion LC-MS/MS Human Plasma ng/ml; ng/ml C-Peptide RIA Human Serum ng/ml N/A C-Peptide RIA Human Serum pg/ml N/A Caffeine LC-MS/MS Human Plasma ng/ml Lithium Caffeine; Paraxanthine LC-MS/MS Human Plasma ng/ml; ng/ml Lithium Candesartan LC-MS/MS Human Plasma ng/ml Candesartan LC-MS/MS Human Plasma ng/ml Capsaicin LC-MS/MS Human Plasma pg/ml Celecoxib LC-MS/MS Human Plasma ng/ml CEMA; 3-HPMA; HBMA LC-MS/MS Human Urine ng/ml; ng/ml; N/A ng/ml Cetirizine LC-MS/MS Human Plasma ng/ml Cetirizine LC-MS/MS Human Plasma ng/ml Chlorpheniramine LC-MS/MS Human Plasma ng/ml Cholecalciferol LC-MS/MS Human Plasma ng/ml Clarithromycin; 14-Hydroxy-Clarithromycin LC-MS/MS Human Plasma ng/ml; ng/ml Clavulanic Acid LC-MS/MS Human Plasma ng/ml Clodronate LC-MS/MS Human Plasma ng/ml Clonazepam LC-MS/MS Human Plasma ng/ml Clopidogrel; Clopidogrel Acid LC-MS/MS Human Plasma ng/ml; ng/ml Codeine LC-MS/MS Human Plasma ng/ml; ng/ml Colchicine LC-MS/MS Human Plasma ng/ml Cortisol; 6-Beta-Hydroxycortisol LC-MS/MS Human Urine ng/ml; ng/ml N/A Global List of Validated Bioanalytical Assays Q

4 Cortisol; 6-Beta-Hydroxycortisol LC-MS/MS Human Urine ng/ml; ng/ml N/A Cotinine LC-MS/MS Human Saliva ng/ml N/A Cyclosporine A LC-MS/MS Human Whole ng/ml K 2 Blood Cyproterone Acetate; LC-MS/MS Human Plasma ng/ml 15-Beta-Hydroxycyproterone Acetate Danazol LC-MS/MS Human Plasma ng/ml K 3 Danazol LC-MS/MS Human Serum ng/ml N/A Darifenacin LC-MS/MS Human Plasma ng/ml Deferiprone LC-MS/MS Human Serum ug/ml N/A Desipramine LC-MS/MS Human Plasma ng/ml Desmopressin LC-MS/MS Human Plasma pg/ml K 3 Dexamethasone LC-MS/MS Human Plasma ng/ml Dexlansoprazole LC-MS/MS Human Plasma ng/ml Dextromethorphan; Dextrorphan LC-MS/MS Rat Plasma ng/ml; ng/ml, Dextromethorphan; Dextrorphan LC-MS/MS Dog Plasma ng/ml; ng/ml Dextromethorphan; Dextrorphan LC-MS/MS Human Plasma ng/ml; ng/ml Dextromethorphan; Dextrorphan LC-MS/MS Mouse Plasma ng/ml; ng/ml Dextromethorphan; Dextrorphan (total) LC-MS/MS Human Urine ng/ml; ng/ml N/A Dextromethorphan; Dextrorphan (total); 3-Methoxymorphinan LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml Lithium Diazepam; Nordiazepam LC-MS/MS Human Plasma ng/ml Diclofenac LC-MS/MS Human Plasma pg/ml K 2 Diclofenac LC-MS/MS Human Plasma ng/ml Diclofenac LC-MS/MS Human Plasma ng/ml K 2 Digoxin LC-MS/MS Human Plasma pg/ml K 2 Dihydrotestosterone (DHT); Testosterone LC-MS/MS Human Serum pg/ml; pg/ml N/A Diltiazem; Deacetyldiltiazem; LC-MS/MS Human Plasma ng/ml; ng/ml N-Desmethyldiltiazem Diphenhydramine LC-MS/MS Human Plasma ng/ml Dipyridamole LC-MS/MS Human Plasma ng/ml Dolasetron; Hydrodolasetron LC-MS/MS Human Plasma ng/ml Donepezil LC-MS/MS Human Plasma ng/ml Doxylamine LC-MS/MS Human Plasma ng/ml K 2 Dronedarone LC-MS/MS Human Plasma ng/ml Drospirenone LC-MS/MS Human Plasma ng/ml Duloxetine LC-MS/MS Human Plasma ng/ml Efavirenz LC-MS/MS Human Plasma ng/ml Emtricitabine LC-MS/MS Human Plasma ng/ml Enalapril; Enalaprilat LC-MS/MS Human Plasma ng/ml; ng/ml Eprosartan LC-MS/MS Human Plasma ng/ml Eptifibatide LC-MS/MS Human Plasma ng/ml Escitalopram LC-MS/MS Human Plasma ng/ml K 2 Esomeprazole LC-MS/MS Human Plasma ng/ml Global List of Validated Bioanalytical Assays Q

5 Estradiol LC-MS/MS Human Serum pg/ml N/A Ethinyl Estradiol LC-MS/MS Human Plasma pg/ml Exemestane LC-MS/MS Human Plasma ng/ml K 3 Exenatide EIA Human Plasma pg/ml Ezetimibe-Free LC-MS/MS Human Plasma ng/ml Ezetimibe-Total LC-MS/MS Human Plasma ng/ml Famotidine LC-MS/MS Human Plasma ng/ml Febuxostat LC-MS/MS Human Plasma ng/ml Sodium Felodipine LC-MS/MS Human Plasma pg/ml Fenofibrate; Fenofibric Acid; Reduced Fenofibric Acid LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml Fentanyl LC-MS/MS Human Serum pg/ml N/A Fentanyl LC-MS/MS Rabbit Serum pg/ml N/A Fentanyl LC-MS/MS Rat Plasma pg/ml Fentanyl LC-MS/MS Human Plasma pg/ml Fexofenadine LC-MS/MS Human Plasma ng/ml Fexofenadine LC-MS/MS Human Plasma ng/ml Fluoxetine; Duloxetine; LC-MS/MS Human Plasma ng/ml; ng/ml; K 2 Paroxetine; Sertraline ng/ml; ng/ml Flurbiprofen LC-MS/MS Human Plasma ng/ml Fluticasone LC-MS/MS Human Plasma pg/ml K 2 Fluvastatin LC-MS/MS Human Plasma ng/ml K 2 Fluvoxamine LC-MS/MS Human Plasma ng/ml Furosemide LC-MS/MS Human Plasma ug/ml Furosemide LC-MS/MS Human Urine ug/ml N/A Galanthamine LC-MS/MS Human Plasma ng/ml Gemcitabine; dfdu LC-MS/MS Human Plasma ng/ml; ng/ml Gestodene LC-MS/MS Human Plasma pg/ml Glimepiride LC-MS/MS Human Plasma ng/ml Glimepiride; Trans hydroxy Glimepiride LC-MS/MS Human Plasma ng/ml; ng/ml Glucagon LC-MS/MS Human Plasma pg/ml Glucagon LC-MS/MS Rat Plasma ng/ml Glucose Enzyme Assay Human Plasma ug/ml K 3 Glyburide LC-MS/MS Human Plasma ng/ml Glyburide; cis-3-hydroxy Glyburide; LC-MS/MS Human Plasma ng/ml; ng/ml trans-4-hydroxy Glyburide Glyburide; cis-3-hydroxy Glyburide; LC-MS/MS Human Urine ng/ml; ng/ml N/A trans-4-hydroxy Glyburide HEMA LC-MS/MS Human Urine ng/ml N/A Hydrochlorothiazide LC-MS/MS Human Plasma ng/ml Hydrocodone LC-MS/MS Human Plasma ng/ml Ibandronate LC-MS/MS Human Serum ng/ml N/A Ibuprofen LC-MS/MS Human Plasma ug/ml Global List of Validated Bioanalytical Assays Q

6 Ibuprofen LC-MS/MS Human Plasma ug/ml Lithium Indapamide LC-MS/MS Human Whole ng/ml Blood Irbesartan LC-MS/MS Human Plasma ng/ml Isradipine LC-MS/MS Human Plasma pg/ml Ketoconazole LC-MS/MS Human Plasma ng/ml Ketoconazole LC-MS/MS Human Plasma ng/ml Ketoprofen LC-MS/MS Human Plasma ng/ml, Lansoprazole LC-MS/MS Human Plasma ng/ml Lenalidomide LC-MS/MS Human Plasma ng/ml K 2 Letrozole LC-MS/MS Human Plasma ng/ml Levonorgestrel LC-MS/MS Human Plasma pg/ml Losartan; Losartan Acid Metabolite LC-MS/MS Human Plasma ng/ml Sodium Lovastatin; Lovastatin Hydroxy-Acid LC-MS/MS Human Plasma ng/ml; ng/ml Lovastatin; Lovastatin Hydroxy-Acid LC-MS/MS Human Plasma ng/ml Malondialdehyde EIA Human Plasma ng/ml K 2 Mecamylamine LC-MS/MS Human Plasma ng/ml Mesalamine LC-MS/MS Human Plasma ng/ml K 2 Metaxalone LC-MS/MS Human Plasma ng/ml Metformin LC-MS/MS Human Plasma ng/ml Methotrexate LC-MS/MS Human Plasma ng/ml K 2 Methylphenidate LC-MS/MS Dog Plasma ng/ml Methylphenidate LC-MS/MS Human Plasma ng/ml Methylphenidate-d; Methylphenidate-L LC-MS/MS Human Plasma ng/ml; ng/ml Methylphenidate-d; Ritalinic Acid-d; Methylphenidate-L; Ritalinic Acid-L Methylphenidate-d; Ritalinic Acid-d; Methylphenidate-L; Ritalinic Acid-L LC-MS/MS Rat Plasma ng/ml; ng/ml Potassium Oxalate/ Sodium Fluoride LC-MS/MS Mouse Plasma 1-50 ng/ml; ng/ml Potassium Oxalate/ Sodium Fluoride Methylprednisolone LC-MS/MS Dog Plasma ng/ml Metoclopramide LC-MS/MS Human Plasma ng/ml Midazolam; Hydroxymidazolam LC-MS/MS Human Plasma ng/ml; ng/ml Misoprostol Acid LC-MS/MS Human Plasma pg/ml K 2 Mometasone LC-MS/MS Human Plasma pg/ml Monohydroxy-3-Butenyl Mercapturic Acid LC-MS/MS Human Urine ng/ml N/A (MHBMA) Montelukast LC-MS/MS Human Plasma ng/ml Morphine; Morphine-3-Glucuronide; LC-MS/MS Human Serum ng/ml; ng/ml; N/A Morphine-6-Glucuronide ng/ml Morphine; Morphine-3-Glucuronide; Morphine-6-Glucuronide LC-MS/MS Human Plasma ng/ml; ng/ml Global List of Validated Bioanalytical Assays Q

7 Morphine; Morphine-6-Glucuronide LC-MS/MS Human Plasma ng/ml; ng/ml K 3 Moxifloxacin LC-MS/MS Human Plasma ng/ml NAB-Total; NAT-Total LC-MS/MS Human Urine pg/ml; pg/ml N/A Naftifine LC-MS/MS Human Plasma ng/ml K 3 Nalbuphine LC-MS/MS Human Plasma ng/ml Naloxone LC-MS/MS Mouse Plasma ng/ml Naloxone-Free LC-MS/MS Human Plasma ng/ml Naloxone-Total LC-MS/MS Human Plasma pg/ml Naloxone-3-Glucuronide LC-MS/MS Human Plasma pg/ml Naltrexone LC-MS/MS Dog Plasma ng/ml Naltrexone LC-MS/MS Human Serum ng/ml N/A Naltrexone; 6-Beta-Naltrexol LC-MS/MS Human Plasma pg/ml; pg/ml Naltrexone; 6-Beta-Naltrexol LC-MS/MS Human Serum pg/ml N/A Niacin; Nicotinamide; Nicotinuric Acid LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml Nicotine; Cotinine LC-MS/MS Human Serum ng/ml; ng/ml N/A Nicotine; Cotinine LC-MS/MS Human Plasma ng/ml; ng/ml Nicotine; Cotinine LC-MS/MS Human Plasma 1-50 ng/ml; ng/ml Nicotine; Cotinine; trans-3'-hydroxycotinine Nicotine; Cotinine; trans-3'-hydroxycotinine; Nicotine Glucuronide; Cotinine Glucuronide; trans-3'-hydroxycotinine Glucuronide Nicotine; Cotinine; trans-3'-hydroxycotinine; Nicotine Glucuronide; Cotinine Glucuronide; trans-3'-hydroxycotinine Glucuronide LC-MS/MS Human Plasma ng/ml; ng/ml, LC-MS/MS Human Urine ng/ml; ng/ml; N/A ng/ml; ng/ml; ng/ml; ng/ml LC-MS/MS Human Urine ng/ml; ng/ml; ng/ml; ng/ml; ng/ml; ng/ml NNAL-Total LC-MS/MS Human Urine pg/ml N/A NNN; NNAL LC-MS/MS Human Urine pg/ml; pg/ml N/A Nordiazepam LC-MS/MS Human Plasma ng/ml Norethindrone LC-MS/MS Human Plasma ng/ml K 2 Norgestimate; Deacetylnorgestimate LC-MS/MS Human Plasma pg/ml Norgestrel (Reported as Levonorgestrel) LC-MS/MS Human Plasma ng/ml, Olmesartan LC-MS/MS Human Plasma ng/ml Olmesartan LC-MS/MS Human Plasma ng/ml K 3 Omeprazole LC-MS/MS Human Plasma ng/ml Sodium Omeprazole LC-MS/MS Human Plasma ng/ml Ondansetron LC-MS/MS Human Plasma ng/ml Orlistat LC-MS/MS Human Plasma pg/ml Oxybutynin [R]; Oxybutynin [S]; Desethyloxybutynin [R]; Desethyloxybutynin [S] LC-MS/MS Rat Plasma ng/ml; ng/ml K 2 N/A Global List of Validated Bioanalytical Assays Q

8 Oxybutynin [R]; Oxybutynin LC-MS/MS Human Plasma ng/ml [S]; Desethyloxybutynin [R]; Desethyloxybutynin [S] Oxybutynin; Desethyloxybutynin LC-MS/MS Human Plasma ng/ml, Oxybutynin; Desethyloxybutynin LC-MS/MS Human Plasma ng/ml K 2 Oxycodone LC-MS/MS Human Plasma ng/ml, Oxycodone; Noroxycodone LC-MS/MS Human Plasma ng/ml; ng/ml Sodium Oxymorphone LC-MS/MS Human Plasma ng/ml Paliperidone LC-MS/MS Human Plasma ng/ml K 2 Pantoprazole LC-MS/MS Human Plasma ng/ml Paroxetine LC-MS/MS Human Plasma ng/ml Paroxetine LC-MS/MS Human Plasma ng/ml PEG-IFN alpha 2a (Pegasys) EIA Human Serum pg/ml N/A Phentermine LC-MS/MS Human Plasma ng/ml Phenytoin LC-MS/MS Human Plasma ng/ml K 3 Pitavistatin LC-MS/MS Human Plasma ng/ml K 2 Pramipexole LC-MS/MS Human Plasma pg/ml K 2 Pramipexole LC-MS/MS Human Plasma pg/ml K 2 Pravastatin; 3-Alpha-Hydroxy Pravastatin; LC-MS/MS Human Plasma ng/ml Pravastatin Lactone Pravastatin; 3-Alpha Hydroxy Pravastatin; LC-MS/MS Human Urine ng/ml N/A Pravastatin Lactone Prednisone; Prednisolone LC-MS/MS Human Plasma ng/ml; ng/ml Progesterone LC-MS/MS Human Plasma ng/ml Progesterone LC-MS/MS Human Serum ng/ml N/A Promethazine LC-MS/MS Human Plasma ng/ml Prostaglandin E2 (PGE-2) EIA Human Urine pg/ml (STD curve N/A pg/ml, DF=3) Pseudoephedrine LC-MS/MS Human Plasma ng/ml PTH 1-34 ELISA Human Plasma pg/ml PTH 1-84 IRMA Human Plasma 4 (anchor point) pg/ml Quetiapine LC-MS/MS Human Plasma ng/ml Quetiapine LC-MS/MS Human Plasma ng/ml Quinidine HPLC/FL Human Plasma ug/ml Quinidine HPLC/FL Human Plasma ng/ml Rabeprazole LC-MS/MS Human Plasma ng/ml Raloxifene LC-MS/MS Human Plasma pg/ml Ramipril; Ramiprilat LC-MS/MS Human Plasma ng/ml Repaglinide LC-MS/MS Human Plasma ng/ml Ribavirin LC-MS/MS Human Serum ng/ml N/A Ribavirin LC-MS/MS Human Red Blood ug/ml Cells Ribavirin LC-MS/MS Human Plasma ng/ml Global List of Validated Bioanalytical Assays Q

9 Rifampin LC-MS/MS Human Plasma ug/ml K 2 Risedronate LC-MS/MS Human Serum pg/ml N/A Ritalinic Acid-d; Ritalinic Acid-L LC-MS/MS Human Plasma ng/ml Ritonavir LC-MS/MS Human Plasma ng/ml Sodium Rivastigmine LC-MS/MS Human Plasma ng/ml K 3 R-Methadone; S-Methadone LC-MS/MS Human Plasma ng/ml K 2 R-Omeprazole; S-Omeprazole LC-MS/MS Human Plasma ng/ml R-Warfarin; S-Warfarin LC-MS/MS Human Plasma ng/ml R-Warfarin; S-Warfarin LC-MS/MS Human Plasma ng/ml Sodium Ropinirole LC-MS/MS Human Plasma ng/ml Rosiglitazone LC-MS/MS Human Plasma ng/ml Rosiglitazone; Desmethylrosiglitazone LC-MS/MS Human Plasma ng/ml Rosuvastatin LC-MS/MS Human Plasma ng/ml Rotigotine LC-MS/MS Human Plasma ng/ml Scopolamine LC-MS/MS Human Plasma pg/ml Sildenafil; Desmethylsildenafil LC-MS/MS Human Plasma ng/ml Simvastatin; Simvastatin Hydroxy Acid LC-MS/MS Human Plasma ng/ml Sitagliptin LC-MS/MS Human Plasma ng/ml Solifenacin LC-MS/MS Human Plasma ng/ml S-Phenyl Mercapturic Acid LC-MS/MS Human Urine ng/ml N/A Sumatriptan LC-MS/MS Human Plasma ng/ml K 2 Sumatriptan LC-MS/MS Human Plasma ng/ml K 2 Tacrolimus LC-MS/MS Human Whole ng/ml K 2 Blood Tadalafil LC-MS/MS Human Plasma ng/ml Tamsulosin LC-MS/MS Human Plasma ng/ml Lithium Telapravir LC-MS/MS Human Plasma ug/ml K 2 Telmisartan LC-MS/MS Human Plasma ng/ml Tenofovir LC-MS/MS Human Plasma ng/ml Testosterone; Methyltestosterone LC-MS/MS Human Plasma ng/ml N/A Tetrahydrocannabinol (THC); THC-OH; THC-COOH LC-MS/MS Human Plasma ng/ml; ng/ml; ng/ml Thalidomide LC-MS/MS Human Plasma ng/ml Theophylline LC-MS/MS Human Plasma ng/ml TNF alpha EIA Human Plasma 1-32 pg/ml Lithium Tolterodine; 5-Hydroxymethyl Tolterodine LC-MS/MS Human Plasma pg/ml; pg/ml Topiramate LC-MS/MS Human Plasma ng/ml Topiramate LC-MS/MS Human Plasma ng/ml Torsemide LC-MS/MS Human Plasma ng/ml Triamcinolone Acetonide LC-MS/MS Human Plasma pg/ml Valsartan LC-MS/MS Human Plasma ng/ml Global List of Validated Bioanalytical Assays Q

10 Valsartan LC-MS/MS Human Serum ng/ml N/A Verapamil; Norverapamil LC-MS/MS Human Plasma ng/ml Verapamil; Norverapamil LC-MS/MS Human Plasma ng/ml Voriconazole LC-MS/MS Human Plasma ng/ml Zidovudine; Abacavir LC-MS/MS Human Plasma ng/ml; ng/ml Zileuton; A66193 LC-MS/MS Human Plasma ug/ml Zoledronate LC-MS/MS Human Serum ng/ml N/A Zoledronate LC-MS/MS Human Urine ng/ml N/A Zolpidem LC-MS/MS Human Plasma ng/ml Zonisamide LC-MS/MS Human Serum ng/ml N/A Biomarker Assays Active Ghrelin ELISA Human Plasma pg/ml K 2 Active GLP-1 ELISA Human Plasma pm K 2 C-Peptide RIA Human Serum ng/ml N/A IGF-1 ELISA Human Plasma ng/ml K 2 IGFBP-3 ELISA Human Plasma ng/ml K 2 IL-6 ELISA Human Serum pg/ml N/A PGE-2 ELISA Human Urine pg/ml N/A PTH 1-34 ELISA Human Plasma pg/ml K 3 PTH 1-84 RIA Human Plasma pg/ml K 3 Total Adiponectin ELISA Human Serum ng/ml N/A Biosimilar Qualified Assays PK Assays - Measurement of Drug in Biological Matrices Technique Species/Matrix Range Anti-coag. Cetuximab ELISA Human Serum ug/ml N/A Rituximab ELISA Human Serum 1-50 ug/ml N/A Peg-Filgrastim (Neulasta) ELISA Human Serum ng/ml N/A Exendin-4 ELISA Human Plasma pg/ml Etanercept (Enbrel) ELISA Human Serum ng/ml N/A Adalimumab (Humira) ELISA Human Serum ng/ml N/A ADA Assays - Measurement of Anti-drug Antibody Assays Technique Species/Matrix Sensitivity Anti-coag. Cetuximab ADA assay ELISA Human Serum 10 ng/ml N/A Rituximab ADA assay ELISA Human Serum 10 ng/ml N/A PTH (1-34) ADA assay ELISA Human Serum 206 ng/ml N/A Global List of Validated Bioanalytical Assays Q

11 Celerion Solution Over 40 years of experience conducting First-in-Human, clinical Proof-of-Concept, cardiac safety services (TQT, robust QT), ADME and NDA-enabling clinical pharmacology studies Global presence with 750 beds at four global Celerion clinical facilities, in addition to a network of audited specialty sites in North America, Europe, South Korea and Singapore. Celerion scans the globe to find solutions to clients early clinical research needs Extensive expertise on modeling and simulation, study design, medical writing (protocols and reports), clinical data sciences, biostatistics, and PK/PD analysis Highly qualified scientists assist in designing robust, efficient clinical studies as well as analyzing and interpreting data both during and post clinical conduct Bioanalytical services at two global locations for method development and validation for small and large molecule assays for the analysis of drugs, metabolites, and biomarkers in a broad range of biological fluids Drug Development Services team provides regulatory, drug development and program management support to complement Celerion s service offering