PETER PAZMANY CATHOLIC UNIVERSITY SEMMELWEIS UNIVERSITY Development of Complex Curricula for Molecular Bionics and Infobionics Programs within a consortial* framework** Consortium leader PETER PAZMANY CATHOLIC UNIVERSITY Consortium members SEMMELWEIS UNIVERSITY, DIALOG CAMPUS PUBLISHER The Project has been realised with the support of the European Union and has been co-financed by the European Social Fund *** **Molekuláris bionika és Infobionika Szakok tananyagának komplex fejlesztése konzorciumi keretben ***A projekt az Európai Unió támogatásával, az Európai Szociális Alap társfinanszírozásával valósul meg. 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 1
Peter Pazmany Catholic University Faculty of Information Technology BEVEZETÉS A FUNKCIONÁLIS NEUROBIOLÓGIÁBA INTRODUCTION TO FUNCTIONAL NEUROBIOLOGY THE NEUROENDOCRINE HYPOTHALAMUS (A neuroendokrin hypothalamus) ZSOLT LIPOSITS 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 2
Hypothalamo-hypophyseal regulation 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 3
Hypothalamo-pituitary unit 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 4
Significance of the endocrine system HPG- system HPT- system HPA-system HPP-system Endocrine pancreas Reproduction Metabolism Adaptation Water, salt balance Carbohydrate metabolism Sterility Graves disease Addison disease Diabetes insipidus Diabetes mellitus MILIEU INTERIEUR 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 5
HYPOTHALAMUS BRAIN STEM AP P P SPINAL CORD TARGET ORGANS AUTONOMIC NERVOUS SYSTEM REPRODUCTION STRESS, ADAPTATION GROWTH FEEDING ENERGY EXPENDITURE THERMOREGULATION WATER AND SALT BALANCE MILK EJECTION SEXUAL BEHAVIOR REGULATION OF VISCERAL FUNCTIONS HOMEOSTASIS 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 6
CONSTITUENTS, BLOOD SUPPLY, NEUROSECRETION NEUROSECRETION 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 7
N E U R A L STALK NEUROHYPOPHYSIS HYPOTHALAMUS SHA PV V A S C U L A R A ADENOHYPOPHYSIS 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 HYPOTHALAMO-HYPOPHYSEAL UNIT
DISCHARGE OF HYPOTHALAMIC RELEASING AND RELEASE-INHIBITING NEUROSECRETORY HORMONES INTO PORTAL CIRCULATION PORTAL CAPILLARIES FROM SUPERIOR HYPOPHYSEAL ARTERY PORTAL VEINS TO ADENOHYPOPHYSIS PP A P DISSEMINATION OF RELEASING AND RELEASE-INHIBITING HORMONES TO HYPOPHYSEAL TROPH CELLS MAGNOCELLULAR parvicellular DISCHARGE OF HYPOPHYSEAL TROPH HORMONES 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 9
AP PP PI 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 10
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W. Bargmann E. Scharrer G. Harris A. Schally J. Szentágothai POA B. Halász B. Flerkó PITUITARY A. Schally, R. Guillemin, W. Vale, J. Rivier O M. Palkovits 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 12
PÉCS From: Szentágothai, J., Flerkó, B., Mess, B., Halász, B., : Hypothalamic Control of the Anterior Pituitary, Akadémiai Kiadó, Budapest, 1962 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 13
PG Anterior LH PS ME CHO Thalamus PVN Rat CM DM VM SCN POA ARC 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 14
GONAD REGULATION O V THERMOREGULATION CORTICAL ACTIVATION SEXUAL BEHAVIOUR L T CA OCH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 15
M P SEXUAL BEHAVIOUR MATERNAL BEHAVIOUR GONAD REGULATION THERMOREGULATION O A 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 16
WATER BALANCE ELECTROLYTE BALANCE MILK EJECTION UTERUS CONTRACTION P V N ADRENAL REGULATION THYROID REGULATION METABOLISM ADAPTATION AUTONOMIC REGULATION GROWTH INHIBITION 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 17
DM VM GROWTH REGULATION FEEDING REGULATION SEXUAL BEHAVIOUR INHIBITION OF LACTATION HORMONE DISCHARGE ARC LH ME 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 18
MB TM LEARNING-MEMORY SLEEP REGULATION 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 19
PVN ANTERIOR POSTERIOR SUBNUCLEI SON 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 20
pc MC III. 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 21
MC 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 22
Thalamus PVN OCH PSHT PS PL 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 23
Vasopressin (antidiuretic hormone, ADH) Blood vessels: vasoconstriction via V1a receptors Anterior pituitary: ACTH release via V1b receptors Kidney: sodium and water reabsorption via V2 receptors Brain: neuromodulation Oxytocin Lactating breast: milk ejection Uterus: smooth muscle contraction Brain: neuromodulation 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 24
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P V N 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 26
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Median eminence Ependymal Hypependymal Internal External Basement membrane 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 29
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PS 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 31
C R H 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 32
Hypothalamic neurosecretory hormones 1. Synthesized in neurons 2. Transported via axo-plasmic flow 3. Stored and released from axon terminals 4. Secreted into the blood stream 5. Have specific receptors 6. Influence target structures via receptor-coupled mechanisms 7. Biologically active 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 33
Retrograde labelling of neurosecretory cells FLUORO-GOLD labelling Hypophysiotrophic somatostain neurons 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 34
rer Nu mrna ISHH protein ICC 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 35
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Luteinizing hormone-releasing hormone (LHRH) Thyrotropin-releasing hormone (TRH) Somatostatin Corticotropin-releasing hormone (CRH) Growth hormone-releasing hormone (GHRH) Dopamine Oxytocin Vasopressin Neurophysin I-II Galanin CART 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 37
Thalamus Medial preoptic area Paraventricular nucleus Periventricular nucleus Arcuate nucleus OCH Supraoptic nucleus pv 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 38
Thalamus MPOA ME OCH LHRH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 39
Pulsatile secretion of GnRH and LH Positive estrogen trigger GnRH and LH peaks induced by estrogen 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 40
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LHRH neurons in the OVLT region of the rat LHRH GAL 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 42
Thalamus PV OCH SOM 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 43
PVN-X CRH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 44
TRH Thalamus PVN OCH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 45
Thalamus GH-RH ARC OCH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 46
SOM GHRH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 47
PNMT-CRH 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 48
HORMONAL FEEDBACK ACTIONS Brain P H A T G Endocrine organs CRH GR Target organs 1987 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 49
Discovery is seeing what everyone has seen and thinking what no one else has thought A. Szent-Györgyi 10/15/2011. TÁMOP 4.1.2-08/2/A/KMR-2009-0006 50