AOU~HT K O H ~ K ~ e M pbkoboahtejl ~ B ~ Ha PeALlqa OT. no KOHKyPCa MMa eamhctbeh KaHAklAaT - AOueHT A ~ H POCMU~

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1 no KOHKyPCa MMa eamhctbeh KaHAklAaT - AOueHT A ~ H POCMU~ K Q H ~ K ~ U ~ B ~ ~, A C T ~ B AOKYMeHTM ~ H M T ~ no KOHKYPCa Ca B CbOTBeTCTBMe C M3MCKBaHklHTa fl0 3aKOHa. AO~~HT K O H ~ K ~ npeacta8r M ~ B ~ 45 HaYYHH ny6n~~au~~, UMTMpaHM 156 nbtm OT 131 CTaTMM, C h klhaekc 5, KaTO TpM OT fly6illl~a~likl~e Ca C M3KntOYMTeJlHO BMCOKa UklTklTPYeMOCT (OKO~O M H ~ 40 A n b ~ (no ~ ) A ~HHH ~a Scopus OT mnvl npvlnome~~e 1). AOU~HT K O H ~ K ~ e M pbkoboahtejl ~ B ~ Ha PeALlqa H~YYHM M3CJleABaHMFI M ApyTM OpraHM3aqMkl: K , H@HM, MOH; ;Vt7,1~7tn(~t1ut~ u Uv2$YHHU cucme,wu. K , H@H M, MOH: :2-lt,:rurno~uri u x2anep~opmu30,7~3~~1~. Jenapharm Gm hh 1997/1998 M3~,ired<;u~e ~r.~y~a~rodyt;li.~palyu csoi~cntrsu Hrl cnaej?oudu UH-sumpo HW C-HXTMY 1 ClM Ku.~uveemoe~o onpede,,.~n~e HU HnpemucmtlpoH (1 npo6zr onl 006poso.;lyu. Aoro~op 3a HayqHO ChTpy~HPiqeCTBO C MHCTIIT~T n ~l '&MROTHOB%~~CTBO YHMB~PCMT~T "CB. KUPM-1 ~ I ~ T U ~ M Clionkie, ". Ma~eno~m. Mjo;iupa~e u xupa~mepu~upa~e q?e~rupumu. AOunrnaywl u penpody~mune~ h.anaqumem npu nmuyu

2 JJoro~op 3a HayqHO CLTpyJHMreCTBO C T~~KH~~CKM YHMB~QCMTCT C~apa 3aropa Eh-o;ro~ztr~/o \./7rlHCHe 21 U ~ U U ~ ~ U hrcinuqtmt~v?l H ~ H nplk dpe6~1u ce.:icmlcmonuhcliu ~tr!ir~oin~ U. TICK HQHM, MOH. A~muo~cuOlrlfrn~u p~.w I~U.MCllUH?OHliH t~pu.~lb ~rh.~t ~t~$epmu~~urnern. H@,,HMVABY07/92 KOIIKY~C C~~~yJlllpa~eHa Hayu~e~eH3WlenBaHIIR. B AH S Hocru mpuuc3.wep~(r UH-crutro nod06uu cucvmcrru 30 KlernhzlHcl xy:lunuouparre ~umo,r!or)e? 3~1 cfi~lp606,?ucrn~a C>U~~~P~IZ{~U~YUH. T~~~CTPBH~H norosop Mewy CY,,Ce.Kn. Oxpa~c~~", HE@ PI CIEWP - EAH. Ocse~ Ha ~scne~osa~enc~a~a cul A~~HOCT, AoqeHT KOH~KYH~B~ otgena s~acr~ren~o speme M eheprm H Ha noarotobkata tia CTyAeHTH M AoKTopaHTH - OT 2001r. e xohopyeah npenoaasaten K ~ M Ka~e~pa "KJle~bqHa 6 ~onor~~ bl na~onofblfl", L~onornrec~n O~KY~T~T, CY " CB. Kn. OXPMACKM", KaTO BOAH ~36~pae~ ~ypc 3a 6a~anaep~ "Mewy lcne~br HM H BbTPeKneTbC(HM KOMYHLIKaTblBHM CMCT~MM", 3aAbflXMTeneH KYPC nb-rnqa B "CLITH~~HCII wre~~a~a" 3a MarmcTpvl cneumanhoct Kne~br~a G~onor~~ M natonorm. llo~ ~ e i pakosoactbo ~ o ycnewho ca sal~(n~~n~ paspa6o~~~~e CM TPMMa AOKTOPaHTM bl UeCT AHnflOMaHTbl, 6nna e PbKOBOAMTen bl Ha eamh cneq~an M 3a HT. ~ O A HaYYHOTO M aamvihmctpatmbh0 PbKOBOACTBOTO Ha AOYeHT K o H ~ K ~ ~ B M eahoblmehhata ~ B ~ CeKuklFl Ha M6PlP, Ha KOFlTO TFI e AbnroroAMueH aaseqaly ce O~OPMR ~1 3au~~a8a npes roahhmte ypes pa3nw~~ ~ayr HM pa3pa60~~~ ~ y n ~ v l ~ ~ c ~ ~ n HayYHo n ~ ~ a p ~ o

3 HanpaBJleHMe - MM~HOH~B~O~HAOK~~~HO~O~~~FI. CneuM@Mre~ O ~ ~ KHa T M3CneABaHMFlTa Ca B ~ ~ M M O ~ ~ ~ C T BMew)/ M R T ~ CTePOMAHM XOPMOHM kl MenaTOHMH TI0 M I~~TO@M~MOJ~OT~~YHM CbCTORHLlR kl e@e~ta Ha Te3M B~~MMOA~~CTBMR BbPXY CllMYHHaTa X O M ~ O C T P~~BMTM~TO ~ ~ ~. Ha Tosa Hanpasnewe B M6MP e ocbtqectseho rpes nopeamua ~~at;lc~pa~u npoem 3a ~scne~osa~enc~a ~efi~oc~ B O ~ ~ ~ C T MHeBpO- T ~ M MMYHOeHAOKPblHOnOrMF1, M O ~ ~ K Y ~ P H ~ ehaokpmhojlormfl kl KneTbYHa GMO~O~MFI, 6 ~ 0 n o r ~ Ha ~ 1 PenPOAYKTMBHM KneTKM. OCHOBHM TeMH B HanpaeneHmero ca: H~B~O~HAOK~MH~H KOHTPOn BbPXY ~HK~MM. Xpo~o6~onorn~1 M HeBPOeHAOKPMHHM MeXaHM3MM Ha aaantaublfi. XOM~OCT~TMYH~ HeBpOeHAOKpMHHa PeiYna~MR Ha LIMyHHaTa PeaKTMBHOCT: Ka~o npklhocm 3HaYeHkle B pa60~llte Ha KaHALlAaTa Ce OTKPOFlBaT CneAHMTe floctll>kehklfl: XOpMOHVl Ha tia~6b6p~~a~a OC nobnmfibbt KOMnOHeHTM Ha PeflpOAyKTVlBHaTa CHCTeMa; XPOHMrHO BMCOKM HMBa Ha rjlt0kokoptmkomam noatmckat 6a3an~a~a n MHA~ UMpaHaTa cekpeqm Ha LH OT x~noqm3a~a 6e3 Aa sac~ra~ cnlyectseho cekpeumta Ha FSH, KaTo e no~a3a~a 3aBMCMMOCT OT HMBOTO Ha nojlobm CTePOblAM B nepti@ep~0~0 K P ~ B O O ~ ~ ~ M U OT ~ HCe30HHaTa M B pe3yntat Ha pa3bmtme Ha Ta3M TeMaTMKa (CTBTMM 18, 20, 21) Ca HaMepeHM KOHKPeTHM HaYr H M AOKa3aTeJlCTBa 3a POnFlTa Ha ~JI~OKOKOPT~KOMAMT~ B KaYeCTBOTO CM Ha "CT~~COB~~ XMBOTHM. HeraTMBHO nobnmfibacl(t4 non0bo-umkjlmyhmte ~ O H M X ~ B ~ ~ 3annOAReMOCTTa ~ K M flpm ~ p e 6 npexmbhl4 ~ ~ Tes~ pe3ynra~~ 3a nbpeu nbt HeAeycMMcneHo nocorsat YYaCTLIe Ha TJltOKOKOPTMKOCTePOMAMTe B MeXaHM3MMTe o T o ~ ~ ~ ~ MCe30HHa o ~ M ~ MOAynaUMFl H ~ Ha HeBpOTpaHCMMCMFlTa OTCTpaHa Ha nonosme CT~POMAM.

4 M3CneABaHMR BbpXy Ha ~ ~ ~ ~ Y HXOPMOH M F I MenaTOHMH KaTO OCHOBeH MeXaHM3bM Ha HeBPOeHAOKPMHHa aaantaumfl Ha PeflpOAyKTklBHMTe npo4ecbl flpm Ce3OHHO pa3mhoxaba~bl Ce BMflOBe; ~ C # I ~ K T Ha MeJlaTOHMHa BbpXy ~MOXMMM~HMT~ XapaKTepMCTMKM rjlk)kokoptmkoci~hmte PeqeflTOpM B XbInOTanaMulyC M xmfloc#im3a, npe~na3sao~~ rvl OT BMA~~~CTBM~TO Ha xpohmrho nosmluehm Ha rnokokoptmomanm HMBa; Paasma e Hoea x~no~e3a 3a ponma Ha MenaTOHLIHa KaTO BaXeH XOMeOCTaTtlCleH CMTHBJl, CMHXPOHbl3MPBU BH~OKPLlHHMTe CeKpeuMll B OpraHM3Ma KaKTO M YCTaHOBFlBa4 XOMeOCTaTMWH 6ana~c Mewy HeBpOeHAOKpMHHaTa kl MMYHHaTa CMCTeMa.

5 Ha OTrOBOP Ha MMYHOKOMneTeHTHM WleTKM, npo~le~leam~~ ceneksmsho cynpecmwo ~enc~s~e sbpxy T-~HTM~~H- KT Ha 3aBMCklMaTa A030-~~BHCMMMRT ~~HXM~HTOP~H MenaTowwa ebpxy Kopenupa flpmcbctbb4eto Ha HM, pel(entopm 3a MenaToHuH; Pe~enrop~~e 3a MenaToHMH ce ekcnpecmpa-r abpxy n ~ o ~ no ~ speme r ~ r Ha e T~XHOTO ametlpahe lnnu xapa~~epw~pa~ OnpeAeneH TMn KneTbClHa cy6nonyna~m, KOFlTO OTCbCTBa MnM e cna6o 3aCTbneHa IlpeAM a KTM BaL(MFITa; n 0-C~L~~CTB~H M T ~ pe3yjltatm csbpaa~~ c AoKaaaHaTa ekcnpecm Ha M~M~P~HHM peuentopn 3a MenaTOHklH BbpXy blmyh0komnetehthm KlleTKM, MHXM~~~TOPHMA B@EKT Ha XOpMOHa BbpXy MMTOTeH-3aBLlCklMa flp0n~$epal(tl5l, B~~MMO&ICTBM~TO Mewy rn~kok0ptmkoll~hm XOPMOHM M MeJlaTOHMH B MOAyflMpaHe eknp@cklflta Ha c~~l&~c~)myhm WIeTbCIHM npotemhm Ll HMBOTO Ha anont03a B MMYHHa TbKaH (CTBTMM 4, 7, 8, 31). ~PMHOC CbC 3HaYeHMe 38 acmctmpahata petlpoaykumf1 Ca M3CneABaHMRTa 3HaYeHMe Ha MenaTOHMHa KaTO CMrHaneH MeXaHM3bM B MbXKaTa PenpOAyKTMBHa CMCTeMa. 3a nbpbm nbt rpe3 LnMYHOL(MTOXtlMML1HM MeTOAM M RT-PCR Ca MA~HTM@M~M~~HM pel@ntopll 3a MenaTOHMH BbPXY KOMneTeHTHM MbXKbl rametm (CT~TMM 14 kl 15). M ~ c ~ ~ ~ ACa B M ~ HKOpenaqMMTe M B ekcnpecmata Ha MeJlaTOHMH kl ApyrM ehaokpmhhn M pactexw Q~KTO~M (wrwoetl aa d e p e ~ ~ ( ~ a qm n ~ r a Qy~~u~nre Ha cnep~a~osotl~~re) B nep~aep~~o ~pb~006paye~~e M CeMeHHaTa nna3~a. c Ca

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