Dr. Szabó Gábor publikációs jegyzéke

Dr. Szabó Gábor publikációs jegyzéke Idegen nyelvű, lektorált közlemények 1 Hegedüs E, Kókai E, Kotlyar A, Dombrádi V, Szabó G. Separation of 1-23-kb complementary DNA strands by urea-agarose gel electrophoresis. Nucleic Acids Res. 2009 Sep;37(17):e112. 2. Katalin Goda, Zsolt Bacsó, Gábor Szabó. Multidrug resistance through the spectacle of P-glycoprotein (review) Current Cancer Drug Targets, 2009 (in press) 3. Fenyvesi F, Fenyvesi E, Szente L, Goda K, Bacsó Z, Bácskay I, Váradi J, Kiss T, Molnár E, Janáky T, Szabó G Jr, Vecsernyés M. P-glycoprotein inhibition by membrane cholesterol modulation. Eur J Pharm Sci. 2008 Aug 7;34(4-5):236-42. Epub 2008 Apr 29. 4. Hegedüs E, Imre L, Pataki J, Lizanecz E, Székvölgyi L, Fazakas F, Bacsó Z, Tóth A, Szabó M, Seres Z, Szabó G. Heteroduplex analysis using flow cytometric microbead assays to detect deletions, insertions, and single-strand lesions. Cytometry A. 2008 Mar;73(3):238-45. 5. Székvölgyi L, Rákosy Z, Bálint BL, Kókai E, Imre L, Vereb G, Bacsó Z, Goda K, Varga S, Balázs M, Dombrádi V, Nagy L, Szabó G. Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14964-9. Epub 2007 Sep 11. Kiss T, 6. Fenyvesi F, Pasztor N, Feher P, Varadi J, Kocsan R, Szente L, Fenyvesi E, Szabo G, Vecsernyes M, Bacskay I. Cytotoxicity of different types of methylated betacyclodextrins and ionic derivatives. Pharmazie. 2007 Jul;62(7):557-8. 7. Goda K, Fenyvesi F, Bacsó Z, Nagy H, Márián T, Megyeri A, Krasznai Z, Juhász I, Vecsernyés M, Szabó G Jr. Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J Pharmacol Exp Ther. 2007 Jan;320(1):81-8. Epub 2006 Oct 18. 8. Székvölgyi L, Bálint BL, Imre L, Goda K, Szabó M, Nagy L, Szabó G. Chip-onbeads: flow-cytometric evaluation of chromatin immunoprecipitation. Cytometry A. 2006 Oct 1;69(10):1086-91. 9. Krasznai ZT, Péli-Szabó J, Németh E, Balkay L, Szabó G, Goda K, Galuska L, Trón L, Major T, Hernádi Z. Paclitaxel modifies the accumulation of tumor-diagnostic tracers in different ways in P-glycoprotein-positive and negative cancer cells. Eur J Pharm Sci. 2006 Jun;28(3):249-56. Epub 2006 Mar 29. 10. Székvölgyi L, Hegedüs E, Molnár M, Bacsó Z, Szarka K, Beck Z, Dombrádi V, Austin C, Szabó G. Nick-forming sequences may be involved in the organization of eukaryotic chromatin into approximately 50 kbp loops. Histochem Cell Biol. 2006 Jan;125(1-2):63-73. Epub 2005 Sep 30. 11. Pataki J, Szabó M, Lantos E, Székvölgyi L, Molnár M, Hegedüs E, Bacsó Z, Kappelmayer J, Lustyik G, Szabó G. Biological microbeads for flow-cytometric immunoassays, enzyme titrations, and quantitative PCR. Cytometry A. 2005 Nov;68(1):45-52.

12. Márián T, Balkay L, Szabó G, Krasznai ZT, Hernádi Z, Galuska L, Szabó-Péli J, Esik O, Trón L, Krasznai Z. Biphasic accumulation kinetics of [99mTc]-hexakis-2- methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P- glycoprotein ligands. Eur J Pharm Sci. 2005 Jun;25(2-3):201-9. Epub 2005 Mar 16. 13. Krasznai ZT, Friedländer E, Nagy A, Szabó G, Vereb G, Goda K, Hernádi Z. Quantitative and functional assay of MDR1/P170-mediated MDR in ascites cells of patients with ovarian cancer. Anticancer Res. 2005 Mar-Apr;25(2A):1187-92. 14. Fenyvesi F, Goda K, Bacso Z, et al. Conformational and topological states of P- glycoprotein, an ABC transporter involved in multidrug resistance: novel assays of transporter modulation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 25: S16-S16 Suppl. 1 MAY 2005 15. Bacso Z, Nagy H, Goda K, Bene L, Fenyvesi F, Matkó J, Szabó G. Raft and cytoskeleton associations of an ABC transporter: P-glycoprotein. Cytometry A. 2004 Oct;61(2):105-16. 16. Gombos I, Bacso Z, Detre C, Nagy H, Goda K, Andrasfalvy M, Szabo G, Matko J. Cholesterol sensitivity of detergent resistance: a rapid flow cytometric test for detecting constitutive or induced raft association of membrane proteins. Cytometry A. 2004 Oct;61(2):117-26. 17. Nagy H, Goda K, Fenyvesi F, Bacsó Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabó G Jr. Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. 18. Szilágyi I, Varga T, Székvölgyi L, Hegedüs E, Goda K, Kaczur V, Bacsó Z, Nakayama Y, Pósafi J, Pongor S, Szabó G Jr. Non-random features of loop-size chromatin fragmentation. J Cell Biochem. 2003 Aug 15;89(6):1193-205. 19. Márián T, Szabó G, Goda K, Nagy H, Szincsák N, Juhász I, Galuska L, Balkay L, Mikecz P, Trón L, Krasznai Z. In vivo and in vitro multitracer analyses of P- glycoprotein expression-related multidrug resistance. Eur J Nucl Med Mol Imaging. 2003 Aug;30(8):1147-54. Epub 2003 Jun 27. 20. Goda K, Nagy H, Mechetner E, Cianfriglia M, Szabó G Jr. Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells. Eur J Biochem. 2002 Jun;269(11):2672-7. 21. Maródi L, Goda K, Palicz A, Szabó G. Cytokine receptor signalling in neonatal macrophages: defective STAT-1 phosphorylation in response to stimulation with IFN-gamma. Clin Exp Immunol. 2001 Dec;126(3):456-60. 22. Nagy H, Goda K, Arceci R, Cianfriglia M, Mechetner E, Szabó G Jr. P- Glycoprotein conformational changes detected by antibody competition. Eur J Biochem. 2001 Apr;268(8):2416-20. 23. Goda K, Nagy H, Bene L, Balázs M, Arceci R, Mechetner E, Szabó G. Conformational heterogeneity of P-glycoprotein. Cancer Detect Prev. 2000;24(5):415-21.

24. Gál I, Varga T, Szilágyi I, Balázs M, Schlammadinger J, Szabó G Jr. Proteaseelicited TUNEL positivity of non-apoptotic fixed cells. J Histochem Cytochem. 2000 Jul;48(7):963-70. 25. Varga T, Szilágyi I, Szabó G Jr. Single-strand breaks in agarose-embedded chromatin of nonapoptotic cells. Biochem Biophys Res Commun. 1999 Oct 22;264(2):388-94. 26. Szabó D, Szabó G Jr, Ocsovszki I, Aszalos A, Molnár J. Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo. Cancer Lett. 1999 May 3;139(1):115-9. 27. Damjanovich S, Bene L, Matkó J, Mátyus L, Krasznai Z, Szabó G Jr, Pieri C, Gáspár R Jr, Szöllösi J. Two-dimensional receptor patterns in the plasma membrane of cells. A critical evaluation of their identification, origin and information content. Biophys Chem. 1999 Dec 13;82(2-3):99-108. 28. Damjanovich S, Matkó J, Mátyus L, Szabó G Jr, Szöllosi J, Pieri JC, Farkas T, Gáspár R Jr. Supramolecular receptor structures in the plasma membrane of lymphocytes revealed by flow cytometric energy transfer, scanning force- and transmission electron-microscopic analyses. Cytometry. 1998 Oct 1;33(2):225-33. 29. Goda K., Nagy E., Kiss A., Telek B., Szabó G.: Simultaneous detection of p- glycoprotein substrates, rhodamine 123 and daunorubicin in multidrug resistant cell lines by high-performance liquid chromatography. Adv. In Chromatography, Electrophoresis and Related Separation Methods 1: 53-60. 1998 30. Marc Heijn, Jan Hooijberg, George L. scheffer, Gábor Szabó, Hans V. Westerhoff and Jan Lankelma: Anthracyclins modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim. Biophys. Acta, 1997, 1326 (1): 112-22 31. Goda K, Balkay L, Márián T, Trón L, Aszalós A, Szabó G Jr. Intracellular ph does not affect drug extrusion by P-glycoprotein. J Photochem Photobiol B. 1996 Jul;34(2-3):177-82. 32. Szabó G Jr, Bacsó Z. Chromatin isolated from viable human PBLs contains DNA fragmented to >/=50 kb. Cell Death Differ. 1996 Apr;3(2):237-41. 33. Goda K, Krasznai Z, Gaspar R, Lankelma J, Westerhoff HV, Damjanovich S, Szabó G Jr. Reversal of multidrug resistance by valinomycin is overcome by CCCP. Biochem Biophys Res Commun. 1996 Feb 15;219(2):306-10. 34. Szabó G Jr. 50-kb chromatin fragmentation in the absence of apoptosis. Exp Cell Res. 1995 Dec;221(2):320-5. 35. Szabó G Jr, Weaver JL, Pine PS, Rao PE, Aszalos A. Cross-linking of CD4 in a TCR/CD3-juxtaposed inhibitory state: a pfret study. Biophys J. 1995 Mar;68(3):1170-6. 36. Szabo G Jr, Pine PS, Weaver JL, Rao PE, Aszalos A. The L-selectin (Leu8) molecule is associated with the TcR/CD3 receptor; fluorescence energy transfer measurements on live cells. Immunol Cell Biol. 1994 Aug;72(4):319-25. 37. Szabó G Jr, Weaver JL, Pine PS, Aszalos A. Specific disengagement of cell-bound anti-lam-1 (anti-l-selectin) antibodies by aurintricarboxylic acid. Mol Immunol. 1993 Dec;30(18):1689-94.

38. Weaver JL, Szabo G Jr, Pine PS, Gottesman MM, Goldenberg S, Aszalos A. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. Int J Cancer. 1993 May 28;54(3):456-61. 39. Szabò G Jr, Pine PS, Weaver JL, Rao PE, Aszalos A. CD4 changes conformation upon ligand binding. J Immunol. 1992 Dec 1;149(11):3596-604. 40. Szabó, G., jr., Pine, P., S., Weaver, J., L., Kasari, M., Aszalos, A.: Epitope mapping by photobleaching fluorescence resonance energy transfer measurements using a laser scanning microscope system. Biophys. J. 1992. 61, 661-670. 41. Szabó G Jr, Székely L, Schablik M, Klein G, Sümegi J, Szabó G. Inositol derivatives down-regulate c-myc inducing growth arrest without differentiation. Exp Cell Res. 1991 Apr;193(2):420-4. 42. Szabó G Jr, Boldog F, Wikonkál N. Disassembly of chromatin into approximately equal to 50 kb units by detergent. Biochem Biophys Res Commun. 1990 Jun 15;169(2):706-12. 43. Szabó G Jr, Damjanovich S. Fluorescent staphylococci as microbeads. Cytometry. 1989 Nov;10(6):801-2. 44. Szabo G Jr, Rédai I Jr, Bacso Z, Hevessy J, Damjanovich S. Light-induced permeabilization and merocyanine 540 staining of mouse spleen cells. Biochim Biophys Acta. 1989 Mar 13;979(3):365-70. 45. Szabó G Jr, Winberg G, Henriksson M, Klein G, Sümegi J. Efficient retroviral transfer of a mouse c-myc construct into HL60. Biochem Biophys Res Commun. 1989 Aug 30;163(1):321-7. 46. Szabó,G.jr., Somogyi, B. and Damjanovich, S.: Macromolecular fluctuation and biological function. J. Molecular Liquids, 1989. 42, 59-70. 47. Szabó G Jr, Bunce C, Brown G, Klein G, Sümegi J. Independent variations of myc amplification, inducibility, maturation, and proliferation states in HL60. Exp Cell Res. 1988 Apr;175(2):334-43. 48. Sejersen, T., Rahm, M., Szabó, G., jr., Ingvarsson, S., Sumegi, J.: Similarities and differences in the regulation of N-myc and c-myc genes in murine embryonal carcinoma cells. Exp Cell Res 1987. 172(2), 304-17. 49. Takács T, Szöllösi J, Balázs M, Gáspár R, Mátyus L, Szabó G, Trón L, Resli I, Damjanovich S. Flow cytometric determination of the sperm cell number in diluted bull semen samples by DNA staining method. Acta Biochim Biophys Hung. 1987;22(1):45-57. 50. Szabó G Jr, Damjanovich S, Sümegi J, Klein G. Overall changes in chromatin sensitivity to DNase I during differentiation. Exp Cell Res. 1987 Mar;169(1):158-68. 51. Damjanovich S, Trón L, Szöllösi J, Mátyus L, Szabó G Jr. Dynamic properties of the murine histocompatibility H-2Kk antigen in cytoplasmic membrane. Mol Immunol. 1984 Dec;21(12):1151-5. Review. No abstract available. 52. Szabó, G., jr., Matyus, L.: A follow-up study of the development of Rauscher erythroleukemia. Cytometry 1984. 5(1), 92-5.

53. Sasvari-Szekely, M., Staub, M., Taljanidisz, J., Szabó, G., jr.,takacs, J., Antoni, F. Cultured tonsillar lymphocytes excrete [3H]thymidine labeled DNA and revert to resting state. Biochem Biophys Res Commun 1984. 125(3), 1110-1116. 54. Mátyus L, Szabó G Jr, Resli I, Gáspár R Jr, Damjanovich S. Flow cytometric analysis of viability of bull sperm cells. Acta Biochim Biophys Acad Sci Hung. 1984;19(3-4):209-14. 55. Szabó, G., Jr., D-Toth, F., Rethy, A.: Cell surface antigens reacting with antiretrovirus sera on normal mouse spleen cells: a flow cytometric study. Cytometry 1983. 4(1), 47-53. 56. Sasvari-Szekely, M., Szabó, G., jr., Staub, M., Spasokukotskaja, T., Antoni, F.: Discrepancies between flow cytometric analysis and [3H]thymidine incorporation in stimulated lymphocytes. Biochim Biophys Acta 1983. 762(3), 452-7. 57. Szabó, G., jr., Kiss, A., Tron, L.: Permeabilization of lymphocytes with polyethylene glycol 1000. Discrimination of permeabilized cells by flow cytometry. Cytometry 1982. 3(1), 59-63. 58. Bartosz G, Szabo G, Szöllösi J, Szöllösi J, Damjanovich S. Aging of the erythrocyte. IX. Fluorescence studies on changes in membrane properties. Mech Ageing Dev. 1981 Jul;16(3):265-74. 59. Szabó G Jr, Kiss A, Damjanovich S. Flow cytometric analysis of the uptake of Hoechst 33342 dye by human lymphocytes. Cytometry. 1981 Jul;2(1):20-3. 60. Szabó, G., jr., Kertesz, J.,C., Laki, K.: Interaction of methylglyoxal with poly-llysine. Biomaterials 1980. 1(1), 27-29. 61. Szabó, G.jr., Szöllősi, J., Gáspár, R.jr.: A new approach to studying cell-cell communication by the use of flow fluorimetry. Acta Biochim. Biophys. Acad. Sci. Hung., 1980. 15, 211-215. 62. Szöllösi J, Szabó G, Somogyi B, Damjanovich S. Simultaneous fluorescence labeling of human fibroblast cells with fluorescamine and propidium iodide. An energy transfer study. Acta Biochim Biophys Acad Sci Hung. 1978;13(1-2):63-6. No abstract available. 63. Hegedüs E, Kókai E, Kotlyar A, Dombrádi V, Szabó G. Separation of 1-23-kb complementary DNA strands by urea-agarose gel electrophoresis. Nucleic Acids Res.2009 Sep;37(17):e112.

Magyar nyelvű közlemények 1. Szöllősi, J., Takács, T., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. I. Objective determination of sperm cell counts in diluted semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1986. 41, 459-463. 2. Szöllősi, J., Takács, T., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. II. Detection of live and dead sperm cell population in semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1986. 41, 731-736. 3. Takács, T., Szöllősi, J., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. III. Biophysical analysis of domestic and imported deep-frozen semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1987. 42, 52-55. 4. Takács, T., Szöllősi, J., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen., IV. Follow-up of changes in the quality of bull semen as a function of time of equilibration before deep-freezing. (in Hungarian) Magyar Állatorvosok Lapja, 1987. 42, 347-353. 5. Szöllősi, J., Takács, T., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. I. Objective determination of sperm cell counts in diluted semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1986. 41, 459-463. 6. Szöllősi, J., Takács, T., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. II. Detection of live and dead sperm cell population in semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1986. 41, 731-736.

7. Takács, T., Szöllősi, J., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen. III. Biophysical analysis of domestic and imported deep-frozen semen samples. (in Hungarian) Magyar Állatorvosok Lapja, 1987. 42, 52-55. 8. Takács, T., Szöllősi, J., Balázs, M., Gáspár, R.jr., Mátyus, L., Szabó, G.jr., Trón, L., Resli, I., Damjanovich, S.: Flow-cytometric evaluation of bull semen., IV. Follow-up of changes in the quality of bull semen as a function of time of equilibration before deep-freezing. (in Hungarian) Magyar Állatorvosok Lapja, 1987. 42, 347-353. Idegen nyelvű könyvfejezetek 1. Trón, L., Szöllősi, J., Szabó, G. jr., Mátyus, L., Damjanovich, S.: Cell surface dynamics and information transfer. In: Tissue Culture and RES. (Eds.: Röchlich P., Bácsy E.) Academic Press, Budapest, pp. 75-83. 1984. 2. Trón, L., Szöllősi, J., Szabó, G. jr., Mátyus, L., Damjanovich, S.: Cell surface dynamics and distance relationship of integral membrane proteins. In: Membrane Dynamics and Transport of Normal and Tumor Cells. (Eds.: Trón L., Damjanovich S., Fonyó A., Somogyi J.) Symp. Biol. Hung., 1984. 26, 307-328. Academic Press, Budapest, 1984. 3. Trón, L., Takács, T., Szöllősi, J., Mátyus, L., Balázs, M., Szabó, G. jr., Gáspár, R.Jr. and Damjanovich, S.: The application of results of theoretical and experimental biological research in animal husbandry. In: Symposion on the Importance of Biotechnology for Future Economic Development, Szeged, Hungary, 3-7 June, 1985. Sc. Tech. Vol. 12 pp. 1-8

4 Szabó, G.jr., Bacso, Zs.: Studies of myc mrna expression in FACS sorted cells. In: ICRO Interntl Course, 9-19 Aug 1989, Debrecen, Hungary Univ Med Sch Debrecen publ (Tron L ed) 5 Matyus, L., Takacs, L., Szabó, G.jr.: Application of fluorescence recovery after photobleaching (FRAP) for lateral mobility measurements in cellular systems. ICRO International Course, 9-19 August 1989. in Debrecen, Hungary, Dept. of Biophysics Med. Universit y School (ed: Tron, L.) 6 Szabó, G.jr., Boldog, F., Wikonkál, N. and Damjanovich, S.: Regularly spaced protein bridges maintain continuity of chromosomal DNA. In: Oncogenesis 6, 189-192; (ed.:t. Papas), Portfolio Publishing Co. 1990. 7 Szabó, G.jr., Bacsó, Zs., Bene, L., Pohubi, L. and Damjanovich, S.: Lack of correlation between c-myc and transferrin-receptor expression in proliferating HL60 cells. In: Oncogenesis 6, 183-187; (ed.: T. Papas), Portfolio Publishing Co. 1990 8 Biofizikai gyakorlatok - Biophysics Laboratory Practices (egyetemi tankönyv magyarul és angolul, DOTE nyomda, 1994) 9 Goda, K., Szakacs, G., Nagy, H., Szabó, G., and Sarkadi, B.: Flow cytometric functional assays for the detection of P-glycoprotein and multidrug resistanceassociated protein. In: Practical guide to physical analysis of cell surface receptors, eds. Z. Krasznai and L. Mátyus, 1998, Debrecen, p. 60, ISBN 963 9070 31 9 10 Analytical Tools for DNA, Genes and Genomes (DNAPress, 2005: ISBN: 0974876518), by Arseni Markoff, ed., Chapter 10: Web servers for the prediction of curvature as well as other DNA characteristics from sequence (Kristian Vlahovicek, László Kaján, Gábor Szabó, Valentina Tosato, Carlo V. Bruschi, and Sándor Pongor)

Magyar nyelvű könyvfejezetek 1. Szabó Gábor ifj., Szöllősi János, Gáspár Rezső: Élő sejpopulációk festék felvételének flow-fluorimetriás vizsgálata. Lumineszcencia Nyári Iskola, (szerk.: Hevessy József és Papp Sándor) 1979. pp. 199-200, II. Országos Lumineszcencia Nyári Iskola, Debrecen, 1979. augusztus 27-28. 2. ifj. dr. Szabó Gábor, dr. Szöllősi János: Fluoreszcencia-aktivált sejt analizis és szortirozás FACS III készülékkel. Modern kutatási módszerek alkalmazásának lehetőségei az orvostudományban (III/a kötet, 129-144. oldal) DOTE, 1984. Magyar nyelvű könyvek 1. Sejtbiológia (tankönyv, szerk.; Medicina, 2004, 2009)