KCD9B9K =;5e "WQ`MWN_^Q\ZW ^M\^\M^Q# >YTMWM^UZY 5Q\Z]ZW

Hasonló dokumentumok
BcXeTg\aZ\afgehVg\bafTaW\afgT Tg\ba\aYbe`Tg\ba. <7*9be`Tcc_\VTg\bafbYgjTeX

PUBLIC VERSION i*! A1=52510!/;8<7-59?!

AXXc\aZ g[x :bvgbe 7jTl3 ;kcxe\`xagt_ ;i\wxavx ba?aixfg`xag \a FeXiXagTg\iX >XT_g[ FebWhVgf

BcXeTg\aZ\afgehVg\baf. <7*fk9be`KCTcc_\VTg\bafbYgjTeX

64B47=4B 4BH=&J=5F4H=CB FI558F D4FHG 46H=CBG 4;F88A8BH. ETWX Tf by <XVX`UXe +,&,*+2. 9XgjXXa

9U^Q!EQ_U_`MZOQ!4 Q YQZ`![R3 GbeT_g! TaW >bbefxgf!ybe6.

;W`\ggXW_l \g [Tf UXVb`X Vb``bac_TVX \a g[x \awhfgel gb _T`Xag g[x WXTeg[ by T

(-, &6-,4 $8*,46-4,)6" #75.1,55 %0)./ $ , '+-,0,5

<a1jfiehr^kzl1 Lnb]^#gb#STUFl# O[X#XTfl#jTl#gb#fgTeg#T#cXaf\ba. Ubfie^1STUF U^e^\m1STUF

Appendix J Photographs of Project Area

VÁLASZLAP ..BF.. KockaKobak Országos Matematikaverseny MINTA Kezdő feladat: KockaKobak Országos Matematikaverseny MINTA 2012.

N[X"UhV^"fgbcf"[XeX5"" Jhgg\aZ"T"iT_hX"ba"lbhe"iT_hX5" PTaZhTeW"`baXl"`Te^Xg"YhaWf

:aw UX TU_X gb W\fVhff ixeut l [bj XTV[ YTVgbe TYYXVgf g[x ctggxea(

!"#$% % &' ()! &!BH# E.$ < < ^!"# ' c &! "! &! L Z 4S Z T\!T F E<6 6"+ #- : $1 -. F E< " (%!F &+" ' `!GF +'!" & &!G & (F V &!G +)%!* +", F &+ M#-. (/-

KockaKobak Országos Matematikaverseny 4. osztály

/01 1!"#$%&'!"#$%&'!"#$%&' () *+,-./ 01! :; CDE 6?289:; FGHIJKLMN O C ( PKL QRSTUV :;*W? CXY? Z[R \] ^ _ `a?o :;?boc^ *+ *+!"#

Készült a Gazdasági Versenyhivatal Versenykultúra Központjának támogatásával november

9]_^ZTe ( 9T`XV\ 7bXZS 6^^_TRXPaT ( 8P\PSXP\ BTVPRf HT_XT`

8. osztály november 18.

Megoldások augusztus 8.

!"#$%" &' # ' $'## '$ '# # ( ) * )!"+,+,, - Y ' ()* +,- B &'. &'.+ +,?0>1! * 1! * E )! 5(61 78 $9 : ;> )1! 8 E & < ;7 6* ;> => 4 B ; A&B

KockaKobak Országos Matematikaverseny osztály

(* ( * 1 ) #1 ( ( -$ / $ * $ #

!"#$ "$ "%$ &' & $ (( $)'*$&&' > 5 _ # * XY9: M $! M %& V ) 0!<K4 `% J Q %=< 89 >) > (-DW,* P )* G \ G M%]H 6 * A = < 4 8 _ %

HIVATALOS ÉRTESÍTÕ. 51. szám. A MAGYAR KÖZLÖNY MELLÉKLETE június 28., hétfõ. Tartalomjegyzék. III. Utasítások, jogi iránymutatások

Ft 5000 Ft 5000 Ft Ft Ft 5000 Ft 5000 Ft 5000 Ft 5000 Ft Ft 5000 Ft Ft Ft 5000 Ft 5000 Ft 5000 Ft 5000 Ft

LEGYEN MÁS A SZENVEDÉLYED!

!"#$ %#"&$' ' &&#""" $!&!"#$&"!&"#!"#$%&' ()!"#$$!!#(!!" #! ) #! $ $ ) #! # *+,-./ :; *+)!#""! *+,-./01 <13./1=*+)!#"" $ >?

))) ),9 ) )*), -*, ( #! $#%KL "# $ %&'!! "#!" #" $%$ # $& ' % ' # % # ( )))* ( +)),- (!"#$%&' )))* (! )))* (" #!#$% " +)),- ($ & ' #!# # %! )))* ) )-

!"#$# $ %&"'" " $$ " ()*)()* * P:QR2 M!" #$% -.()*0 ( 0 01 :- U "0 )*&' ) a C01 C 1 5D 6PW $T0&' ) a ( C ) ) a ( C Z[$T,-O. O P/

!! " ()*+,-./ & 67&8 9 "" /01:; <=>? ()* +, E F GH IJKLMN O PQRST?U-VWXY Z [ +, -./01 E\ ]=^Y/ 0 1 E _ ` a b ] = ^ Y / 0 1 E + X PQRSc +

!!!"#$%&%#'"()*+!,&()*,

+++ +, ++, + + +,. # -!! "#!"#$ %& ' & ' (!%! ) *!"#$%&'+++, * ( )*+,-++++ * -. / 0&'+++ *! " # $ "%& '& $ # +++, '& *! " # # "(% ) * +, '& *'&

!"#$%& ' #$ ()*+,-. /0 1 ()*+ *+., :;- *+ & < DE FG *+ HIJKELM () E NO< %& *+ PQRS T%&#$ U*+VOW X Y V > () ()*+ Z[\ FG #]^_ :%&#

mo2gh?, +,-./ L9o2r ±8²³ Tmn/012r ±C Iµ, "'!( & m ¹º»¼/ ]½¾]3 ÀÁG&32ÂÃÄÅRFaƾHK ÇÈÉÊË^ÌÍÎÏ& Ðo2r a ÑÒÓCÔÕÖ, ØÙÚÛÜ& Ðo2ÝWaÞ32ÂÃßà&9:áy ±&- 3â 6

GYÖRKÖNY TELEPÜLÉSRENDEZÉSI TERVE 1

,- (.,-- /0 & # )11.!"#$%&'! "#$%&' ()*+,-. /01. * : ; 4 DED1 5 $< :1 F GHIJK LMNOE => PQ/RS LMNO TUVW XYS + $< 9:+ LMNO Z9 [\ ]^_`

PRA/282000/M. SMART - HENGER Beépített szeleppel és érzékel vel PRA/282000/M Kétoldali m ködés Ø mm

^àx^bs- liót 2. a v a l o r i z á c i ó által s o k

KockaKobak Országos Matematikaverseny 7. osztály

!"# $$%&''# $ JJ Q KL MN O K C $ #S C $$ 5 3Z B!"+ 5 B T +$ 8 X`(+0!"3 $ )6 #$ L4 4 L\ "T 6 T E E E $E *6 E E ;E $E ; E;;

FO NE TI KA OLVASÓKÖNYV

Fiat Ducato E6 árlista

Fiat személyautó árlista

!"# "#$# %&' $& ( )* "&+ &)" ) % AB &)" % ) ; +3, a ( O () Ga*+,-./012 I "9 * & X O "9 3 & * 1 >?:; : 6 "9 * T: :;K "9 & * 1 T: ; " D>] 9S

Kiképzési Szabályzat

! " #$ % & '( & '+) $ (

KockaKobak Országos Matematikaverseny 8. osztály

!"#$!##%&%' ($"#)*+,-./012,345

Együttműködési ajánlat A társadalmi kohézió erősítése az egyházak közösségfejlesztő tevékenységének bővítésével EFOP Pályázati tervezet 2.

CMYK!!"#$%& ' ( )*+,-./ 01 2" :; <= DE FGH. IJ&K L"MN#O P 7Q FGRS T U"VWGX DY C FGMN# I " P #$Z[ \N#$%&7Q FGRS# I &K L"]^#$_` a

DARKCOMP notebook árlista tel:46/ ACER NOTEBOOK Cikks zám

2...Dpitő ipar 3. IIoző és or doga SCI * 15o 4 Szállitás hi ri özlé G bero eke dől orj 4o0

KockaKobak Országos Matematikaverseny osztály

OSRAM VIP Diamond Lamps. Projector Brand Projector Model No DMS-865 DMS-878

THE LITERARY WORKS OF ŚRĪMANTA ŚAṄKARADEVA AND MAHĀPURUṢA MĀDHAVADEVA

!"#"" $%&'&%" &" " N 6 #$Q % -.== ;; 6 ( =% 3(- ), 58"%="" 0% % $!" % $ 1 " 1% $!"#"% %!!"-.= &!!"1""&% " "0" "&% %% "/"!"#"" $%&'&%" &" 6 X TT/ )* +,

Célterület adatlap. I. Fogalom magyarázat. II. Támogatás vehető igénybe. III. Támogatás mértéke. növelése

!""#$%& $() (* +),-".(/01 2) 3(4()5 246(.$ 7- $) 8+94 :9 (-+ $; <.+;=$)6

!" #$%& ' % '( ) # # '( KLMNO!./0 1 5 H `a )5,) ) ( ;E ) \ J& ] ) 1.^ <B5 ` A) c HE )`7? ; ^ ) : ;;/,!] ) 1.` A ^ N0< ;:)I >? 7) >S,-Q 1. M "2 1.` A M


~/iul«so Û 1/& 4. ( X i X X ^ > - es^ < z v -^ c * < (l_ '^ y N ^ t - y y X / % y]/,< 2^ X - ^ V c*-^y n~ esl ^&(. y < L ^ < í^ d ~ 0 u -

A nyugat-európai kódexek hatása a magyar polgári jogi kodifikációra fedezet- és szerzdésbiztosítéki jogunkban

!" " R 0ª %&ø '! 'tl&ø ) ûuv:ü! #Īýs^¹ -(2 þ! 0ýs. # Äuvq R,-»! âã»ït{ #! "*: # Ä /I2 Q.'tìíyzG (%?) (%&) : #;DE

Opel keréktárcsa katalógus személygépkocsikhoz

Opel Combo CV. Van L1H1 normál teherbírás. Van L1H1. megnövelt teherbírás Van L1H1. Van L2H1 megnövelt teherbírás

) < &- :5) 5 0A %./,0 ) % % % < ) A ) : "=> %) A ) P %))A ) < " %) 1 'E" G; * 'E" * E (* E 3* ` 0 E 3 N 1 8 < " Z Z [ 0 < 0 1 E 3N "ZZ[

& ()*+,-. ()%*+,"%%-(%.#!$$"%$ &$ %!"#$%& "( )*+%,-,."/+,01 ("$ )"$$"-+"% &%2 3$"0,/0+"%

2004-ben végze a Budapesti Közgazdaságtudományi

KockaKobak Országos Matematikaverseny 10. osztály

ÜZLETSZABÁLYZAT 1. sz. módosítása egységes szerkezetbe foglalva


PÉLDATÁR KÖLTSÉGVETÉSI SZERVEK SZÁMVITELE MEGFELELT SZINT 50%

A Magyar Nemzeti Bank elnökének 19/2012. (X. 4.) MNB rendelete

Szigethalom Városi Szabadid központ

M/1000 Nehézüzemi hengerek

C qe.rrrc ocboeitur t BHelpettrr leps,qoboro orerlecrbehhofo u. 09 yrbepx\aehhh fljrahob oopa3obatenbhbix MepoIIpHtTr{fi u otokhpobok 3a pyoexom

KockaKobak Országos Matematikaverseny 7. osztály

) %#!!" # $!"#$%&"'$ ()*+,-!./01 %! :;, < (CD%E '5 FGHIJKLMNO PMQ%RS.TU5! V (WX!%67#'Y! ( V Z[\]^_`a )8b67% c V K$ %CD 5T (% ( F

!"#$!##%&%' ($"#)*+,-./0!0#%0#1,234


ÁRLISTA. Bruttó ár regisztációs adóval (Ft) Regisztrációs adó (Ft) Modell Kód Váltó Üzemanyag Nettó ár (Ft)

Heckenast Gusztáv könyvkiadó-hivatali. ban (Pesten, egyetem-utcza 4. sz.) megjelent és minden könyvárusnál kapható: 1849-ben

ÁRLISTA. Bruttó ár regisztációs adóval (Ft) Regisztrációs adó (Ft) Modell Kód Váltó Üzemanyag Nettó ár (Ft)

XIII. KERÜLET HOSSZÚ TÁVÚ FEJLESZTÉSI KONCEPCIÓ

Célterület adatlap. Szolgáltatáscsomag: azonos tevékenység, téma köré szerveződő szolgáltatások összekapcsolt halmaza.

0.9 TwinAir Turbo PopStar V PopStar. (g/km) 117** 117** ** 99 Végsebesség (km/h)

()*+, &'678 9( :; : 4. 89:; "# "# < < = ":> < A BC D<= E GH$2.34 H FGH CD IJ * K *L MD6 NO LM LPQ R ST" # <, RU D BV <WD <X Y, T H - C b9 T

SZABÁLYSÉRTÉSI IRATOK ÜGYKEZELÉSI SZABÁLYZATA


!"#$%&' $ ()*+,-!./0 1! 234! :;! )*+1 < )* -7 7FG1HI? )*+J KLMN-! O 4 P! QRS 23)*+1,TU V W6 XY )*+J > )*+Z[!\]L^G2 _`)*ab c < 4?< )

' 0.*)& )0- ) $ &!"# ' $% : 01 #$ % ; : 456 &!"#$%&' ( )*+,- ( )' *+ $, - ),,".') / ' *!./ :; &!"#$%&' ( + + <= DE 0 1' #

KockaKobak Országos Matematikaverseny 8. osztály

;RÇÈ^B & *+ B ( "<$%!cl. ()&*+ =)cb ( "<$%!cl ( )&Ë̹ B"C`g=%)&Z")B7"ÍÎ=IGÏÐeÑÒ& ¾ "<$%!cl :; "VW ¼

!! "#$ & % & %% &!"#$%&' ( )*+,-./01! "#$% &' &' %! " #"$ % 0# (0 (1# (.* (1,. 1# ( # $ ( # ( (!/ 23 #,2 / 4. 5 ( 6.3 2$.3 #,2 / # * 23 #,2 / 4. 5 ( %

Bruttó eladási ár áfával és regisztrációs adóval:

!"#$% &' (')*+,-. /0 &')1 * 234)56 78&'9:;, DE > FGHIJKLMN>O P>QRISTUVW XY O V> Z[ O;\ ]^ _`ab c C Y >Q F >QR 23!"#$%&' () *+,-./)0"1 ) 2)3 4

/ & $ ' :$/&;. 2 */ * $ :$ 4. / $ && . 2 " #$% &'% ( + *, - $. /& 01 2 ) * & $ 1 2 ' ( ) *&$#$ ( * $"$

+,-!.,/#0-! "-',/,-0 )45 1 # 1 11 #// 5(( &!.! &' & ()&**!& &&&!"#$%!" # $%&' () $% # *+,-./)!" # 01 + ) !" :; 89 DE3 689! * F

. NAPIREND Ügyiratszám: /2012.

Átírás:

KCD9B9K =;5e "WQ`MWN_^Q\ZW ^M\^\M^Q# >YTMWM^UZY 5Q\Z]ZW ;Z\ C\MW >YTMWM^UZY CYWb PRESCRIBING INFORMATION DESCRIPTION K[X TVg\iX Vb`cbaXag by OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ \f _XiT_UhgXeb_ gtegetgx& g[x #I$'XaTag\b`Xe by T_UhgXeb_( CXiT_UhgXeb_ gtegetgx \f T ex_tg\ix_l fx_xvg\ix UXgT, 'TWeXaXeZ\V exvxcgbe TZba\fg #fxx 7@>B>75@ D=5EA57C@C<L$( CXiT_UhgXeb_ gtegetgx [Tf g[x V[X`\VT_ at`x #I$'" + 'RR#+&+'W\`Xg[l_Xg[l_$T`\abS`Xg[l_S'.'[lWebkl'+&-'UXamXaXW\`Xg[Tab_ C'gTegeTgX #,4+ ft_g$& TaW \g [Tf g[x Yb bj\az V[X`\VT_ fgehvghex4 OH H N HO OH HO HOOC COOH OH 2 K[X `b_xvh_te jx\z[g by _XiT_UhgXeb_ gtegetgx \f 0,2(1+& TaW \gf X`c\e\VT_ Ybe`h_T \f #9 +-?,+ EF - $, u 9.? 0 F 0 ( @g \f T j[\gx gb _\Z[g'lX bj fb_\w& YeXX_l fb_hu_x \a jtgxe TaW ixel f_\z[g_l fb_hu_x \a Xg[Tab_( CXiT_UhgXeb_ gtegetgx \f g[x ZXaXe\V at`x Ybe #I$'T_UhgXeb_ gtegetgx \a g[x La\gXW JgTgXf( OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \f T cexffhe\mxw `XgXeXW'WbfX TXebfb_ \a[t_xe #D;@$& j[\v[ cebwhvxf Ta TXebfb_ Ybe bet_ \a[t_tg\ba( @g VbagT\af T fhfcxaf\ba by `\Veba\mXW _XiT_UhgXeb_ gtegetgx& cebcx Tag?=7'+-.T #+&+&+&,'gxgety_hbebxg[tax$& ;X[lWeTgXW 7_Vb[b_ LJG& TaW F_X\V 7V\W E=( K[X \a[t_xe f[bh_w UX ce\`xw Ul ex_xtf\az. fcetlf \agb g[x T\e& TjTl Yeb` g[x YTVX& UXYbeX hf\az \g Ybe g[x Y\efg g\`x TaW j[xa g[x \a[t_xe [Tf abg UXXa hfxw Ybe `bex g[ta - WTlf( 7YgXe ce\`\az j\g[. TVghTg\baf& XTV[ TVghTg\ba WX_\iXef /3 `VZ by _XiT_UhgXeb_ gtegetgx #Xdh\iT_Xag gb./ `VZ by _XiT_UhgXeb_ YeXX UTfX$ Yeb` g[x TVghTgbe #be `bhg[c\xvx$( <TV[ +/ Z VTa\fgXe cebi\wxf,** TVghTg\baf #be \a[t_tg\baf$ TaW XTV[ 2(. Z VTa\fgXe cebi\wxf 2* TVghTg\baf #be \a[t_tg\baf$( K[\f cebwhvg WbXf abg VbagT\a V[_bebY_hbebVTeUbaf #9=9f$( CLINICAL PHARMACOLOGY AQOTMYU]X ZR 5O^UZY2 7Vg\iTg\ba by UXgT, 'TWeXaXeZ\V exvxcgbef ba T\ejTl f`bbg[ `hfv_x _XTWf gb g[x TVg\iTg\ba by TWXal_TgX VlV_TfX TaW gb Ta \avextfx \a g[x \agetvx h_te VbaVXageTg\ba by VlV_\V'-"& /"'TWXabf\aX `babc[bfc[tgx #VlV_\V 7DG$( K[X \avextfx \a VlV_\V 7DG \f TffbV\TgXW j\g[ g[x TVg\iTg\ba by cebgx\a ^\atfx 7& j[\v[ \a ghea& \a[\u\gf )

g[x c[bfc[bel_tg\ba by `lbf\a TaW _bjxef \agetvx h_te \ba\v VT_V\h` VbaVXageTg\baf& exfh_g\az \a `hfv_x ex_tktg\ba( CXiT_UhgXeb_ ex_tkxf g[x f`bbg[ `hfv_xf by T T\ejTlf& Yeb` g[x getv[xt gb g[x gxe`\at_ UebaV[\b_Xf( @avextfxw VlV_\V 7DG VbaVXageTg\baf TeX T_fb TffbV\TgXW j\g[ g[x \a[\u\g\ba by g[x ex_xtfx by `XW\Tgbef Yeb` `Tfg VX f \a g[x T\ejTlf( CXiT_UhgXeb_ TVgf Tf T YhaVg\baT_ TagTZba\fg gb ex_tk g[x T\ejTl \eexfcxvg\ix by g[x fctf`bzxa \aib_ixw& g[hf cebgxvg\az TZT\afg T UebaV[bVbafge\Vgbe V[T XaZXf( N[\_X \g \f exvbza\mxw g[tg UXgT, 'TWeXaXeZ\V exvxcgbef TeX g[x cexwb`\atag exvxcgbef ba UebaV[\T_ f`bbg[ `hfv_x& WTgT \aw\vtgx g[tg g[xex TeX UXgT'eXVXcgbef \a g[x [h`ta [XTeg& +*! gb /*! by j[\v[ TeX UXgT, 'TWeXaXeZ\V exvxcgbef( K[X cexv\fx YhaVg\ba by g[xfx exvxcgbef [Tf abg UXXa XfgTU_\f[XW #fxx J5EB>B<F$(?bjXiXe& T UXgT'TWeXaXeZ\V TZba\fg WehZf VTa cebwhvx T f\za\y\vtag VTeW\biTfVh_Te XYYXVg \a fb`x ctg\xagf& Tf `XTfheXW Ul ch_fx etgx& U_bbW cexffhex& fl`cgb`f& TaW)be X_XVgebVTeW\bZeTc[\V V[TaZXf( Preclinical IXfh_gf Yeb` \a i\geb fghw\xf by U\aW\aZ gb [h`ta UXgT'TWeXaXeZ\V exvxcgbef WX`bafgeTgXW g[tg _XiT_UhgXeb_ [Tf Tccebk\`TgX_l,'Yb_W ZeXTgXe U\aW\aZ TYY\a\gl g[ta etvx`\v T_UhgXeb_ TaW Tccebk\`TgX_l +**'Yb_W ZeXTgXe U\aW\aZ TYY\a\gl g[ta #J$'T_UhgXeb_( @a Zh\aXT c\z T\ejTlf& _XiT_UhgXeb_?9_ TaW etvx`\v T_UhgXeb_ WXVeXTfXW g[x exfcbafx gb fctf`bzxaf #X(Z(& TVXgl_V[b_\aX TaW [\fgt`\ax$& j[xextf #J$'T_UhgXeb_ jtf \axyyxvg\ix( K[XfX exfh_gf fhzzxfg g[tg g[x UebaV[bW\_Tgbel XYYXVgf by etvx`\v T_UhgXeb_ TeX Tgge\UhgTU_X gb g[x #I$'XaTag\b`Xe( @agetixabhf fghw\xf \a etgf j\g[ etvx`\v T_UhgXeb_ fh_ytgx [TiX WX`bafgeTgXW g[tg T_UhgXeb_ VebffXf g[x U_bbW'UeT\a UTee\Xe TaW extv[xf UeT\a VbaVXageTg\baf T`bhag\aZ gb Tccebk\`TgX_l /(*! by g[x c_tf`t VbaVXageTg\baf( @a fgehvghexf bhgf\wx g[x U_bbW'UeT\a UTee\Xe #c\axt_ TaW c\gh\gtel Z_TaWf$& etvx`\v T_UhgXeb_ VbaVXageTg\baf jxex YbhaW gb UX +** g\`xf g[bfx \a g[x j[b_x UeT\a( JghW\Xf \a _TUbeTgbel Ta\`T_f #`\a\c\zf& ebwxagf& TaW WbZf$ [TiX WX`bafgeTgXW g[x bvvheexavx by VTeW\TV Tee[lg[`\Tf TaW fhwwxa WXTg[ #j\g[ [\fgb_bz\v Xi\WXaVX by `lbvtew\t_ axvebf\f$ j[xa UXgT'TZba\fgf TaW `Xg[l_kTag[\aXf TeX TW`\a\fgXeXW VbaVheeXag_l( K[X V_\a\VT_ f\za\y\vtavx by g[xfx Y\aW\aZf \f ha^abja( GebcX Tag?=7'+-.T \f WXib\W by c[te`tvb_bz\vt_ TVg\i\gl XkVXcg Tg ixel [\Z[ WbfXf \a Ta\`T_f #-2* gb +-** g\`xf g[x `Tk\`h` [h`ta XkcbfheX UTfXW ba Vb`cTe\fbaf by 7L9 it_hxf$& ce\`te\_l cebwhv\az TgTk\T& gex`bef& WlfcaXT& be ft_\itg\ba( K[XfX TeX f\`\_te gb XYYXVgf cebwhvxw Ul g[x fgehvghet l ex_tgxw V[_bebY_hbebVTeUbaf #9=9f$& j[\v[ [TiX UXXa hfxw XkgXaf\iX_l \a `XgXeXW'WbfX \a[t_xef( @a Ta\`T_f TaW [h`taf& cebcx Tag?=7'+-.T jtf YbhaW gb UX etc\w_l TUfbeUXW TaW etc\w_l X_\`\aTgXW& j\g[ Ta X_\`\aTg\ba [T_Y'_\YX by - gb,1 `\ahgxf \a Ta\`T_f TaW / gb 1 `\ahgxf \a [h`taf( K\`X gb `Tk\`h` c_tf`t VbaVXageTg\ba #g`tk $ TaW `XTa exf\wxavx g\`x TeX Ubg[ XkgeX`X_l f[beg& _XTW\aZ gb T getaf\xag TccXTeTaVX by?=7'+-.t \a g[x U_bbW j\g[ ab Xi\WXaVX by TVVh`h_Tg\ba( *

Pharmacokinetics 7 cbch_tg\ba c[te`tvb^\axg\v #GGB$ `bwx_ jtf WXiX_bcXW hf\az c_tf`t VbaVXageTg\baf by #I$'T_UhgXeb_ bugt\axw Yeb` 0-, Tfg[`Tg\V ctg\xagf TZXW. gb 2+ lxtef \a g[exx _TeZX ge\t_f( K[X GGB `bwx_'wxe\ixw c[te`tvb^\axg\v ctet`xgxef Ybe #I$'T_UhgXeb_ \a cxw\tge\v TaW TWb_XfVXag)TWh_g ctg\xagf exvx\i\az T 3* `VZ WbfX by OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ be T +2* `VZ WbfX by etvx`\v T_UhgXeb_ Ul?=7 `XgXeXW'WbfX \a[t_xe TeX cexfxagxw \a KTU_X +( K[XfX c[te`tvb^\axg\v WTgT \aw\vtgx g[tg `XTa XkcbfheX gb #I$'T_UhgXeb_ jtf +-! gb +0! _Xff \a TWh_g TaW -*! gb -,! _Xff \a cxw\tge\v ctg\xagf Z\iXa OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ Tf Vb`cTeXW gb g[bfx Z\iXa T Vb`cTeTU_X WbfX by etvx`\v T_UhgXeb_( N[Xa Vb`cTeXW gb TWh_g ctg\xagf& cxw\tge\v ctg\xagf Z\iXa 3* `VZ by _XiT_UhgXeb_ [TiX T +1! _bjxe `XTa XkcbfheX gb #I$'T_UhgXeb_( GMNWQ )2 AQMY AZPQW&D\QPUO^QP "E#&5WN_^Q\ZW DTM\XMOZVUYQ^UO DM\MXQ^Q\] F^_Pb DZ[_WM^UZY 7Wb_XfVXag)7Wh_g GTg\Xagf #"+, lxtef$ GXW\Tge\V GTg\Xagf #.'++ lxtef$ DM\MXQ^Q\ KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW G\QM^XQY^ EMOQXUO 5WN_^Q\ZW =;5 A8> 9`Tk #az)`c$ *(+33 *(,-2 g`tk #[e$ *(/. *(/- 7L9 #*'0$ #azu[e)`c$ *(03/ *(132 9`Tk #az)`c$ *(+0- *(,-2 g`tk #[e$ *(10 *(12 7L9 #*'0$ #azu[e)`c$ *(/13 *(2,2 Metabolism and Elimination @aybe`tg\ba TiT\_TU_X \a g[x chu_\f[xw _\gxetghex fhzzxfgf g[tg g[x ce\`tel Xaml`X exfcbaf\u_x Ybe g[x `XgTUb_\f` by T_UhgXeb_ XaTag\b`Xef \a [h`taf \f JLCK+7- #fh_ybgetafyxetfx$( N[Xa etvx`\v T_UhgXeb_ jtf TW`\a\fgXeXW X\g[Xe \agetixabhf_l be i\t \a[t_tg\ba TYgXe bet_ V[TeVbT_ TW`\a\fgeTg\ba& g[xex jtf T -' gb.'yb_w W\YYXeXaVX \a g[x TeXT hawxe g[x VbaVXageTg\ba'g\`X VheiXf UXgjXXa g[x #I$' TaW #J$'T_UhgXeb_ XaTag\b`Xef& j\g[ #J$'T_UhgXeb_ VbaVXageTg\baf UX\aZ Vbaf\fgXag_l [\Z[Xe(?bjXiXe& j\g[bhg V[TeVbT_ cexgextg`xag& TYgXe X\g[Xe bet_ be \a[t_tg\ba TW`\a\fgeTg\ba g[x W\YYXeXaVXf jxex 2' gb,.' Yb_W& fhzzxfg\az g[tg #I$'T_UhgXeb_ \f cexyxexag\t l `XgTUb_\mXW \a g[x ZTfgeb\agXfg\aT_ getvg& cexfh`tu_l Ul JLCK+7-( K[X ce\`tel ebhgx by X_\`\aTg\ba by T_UhgXeb_ XaTag\b`Xef \f g[ebhz[ exat_ XkVeXg\ba #2*! gb +**!$ by X\g[Xe g[x ctexag Vb`cbhaW be g[x ce\`tel `XgTUb_\gX( CXff g[ta,*! by g[x WehZ \f WXgXVgXW \a g[x YXVXf( =b bj\az \agetixabhf TW`\a\fgeTg\ba by etvx`\v T_UhgXeb_& UXgjXXa,/! TaW.0! by g[x #I$'T_UhgXeb_ YeTVg\ba by g[x WbfX jtf XkVeXgXW Tf hav[tazxw #I$'T_UhgXeb_ \a g[x he\ax( +

Special Populations Hepatic Impairment: K[X XYYXVg by [XcTg\V \`ct\e`xag ba g[x c[te`tvb^\axg\vf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ [Tf abg UXXa XiT_hTgXW( Renal Impairment: K[X XYYXVg by exat_ \`ct\e`xag ba g[x c[te`tvb^\axg\vf by etvx`\v T_UhgXeb_ jtf XiT_hTgXW \a / fhu]xvgf j\g[ VeXTg\a\aX V_XTeTaVX by 1 gb /- `C)`\a& TaW g[x exfh_gf jxex Vb`cTeXW j\g[ g[bfx Yeb` [XT_g[l ib_hagxxef( IXaT_ W\fXTfX [TW ab XYYXVg ba g[x [T_Y'_\YX& Uhg g[xex jtf T 01! WXV_\aX \a etvx`\v T_UhgXeb_ V_XTeTaVX( 9Thg\ba f[bh_w UX hfxw j[xa TW`\a\fgXe\aZ [\Z[ WbfXf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ gb ctg\xagf j\g[ exat_ \`ct\e`xag( Clinical Trials 5P_W^] MYP 5PZWQ]OQY^]2 K[X XYY\VTVl TaW ftyxgl by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ jxex XfgTU_\f[XW \a gjb 2'jXX^& `h_g\vxagxe& etawb`\mxw& WbhU_X'U_\aW& TVg\iX' TaW c_tvxub'vbageb XW ge\t_f \a 1.2 TWh_gf TaW TWb_XfVXagf j\g[ Tfg[`T UXgjXXa g[x TZXf by +, TaW 2+ lxtef( @a g[xfx gjb ge\t_f& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ #.*- ctg\xagf$ jtf Vb`cTeXW gb Ta?=7'+-.T c_tvxub D;@ #+00 ctg\xagf$& TaW g[x ge\t_f \av_hwxw T `Te^XgXW T_UhgXeb_?=7'+-.T D;@ #+13 ctg\xagf$ Tf Ta TVg\iX Vbageb_( JXe\T_ YbeVXW Xkc\eTgbel ib_h`x \a + fxvbaw #=<M + $ `XTfheX`Xagf WX`bafgeTgXW g[tg 3* `VZ #, \a[t_tg\baf$ by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ cebwhvxw f\za\y\vtag_l ZeXTgXe \`cebix`xag \a =<M + bixe g[x cexgextg`xag it_hx g[ta c_tvxub( K[X exfh_gf Yeb` bax by g[x ge\t_f TeX f[bja \a =\ZheX + Tf g[x `XTa cxevxag V[TaZX \a =<M + Yeb` gxfg'wtl UTfX_\aX Tg ;Tl + #a6../$ TaW ;Tl /0 #a6-21$( K[X exfh_gf Yeb` g[x fxvbaw ge\t_ jxex f\`\_te(,

;US_\Q )2 DQ\OQY^ 7TMYSQ UY ;9I ) R\ZX GQ]^&8Mb 6M]QWUYQ UY 5P_W^] MYP 5PZWQ]OQY^] 5SQP )* ^Z 0) LQM\] M^ 8Mb ) MYP 8Mb -. Mean % Change in FEV 1 30 25 20 15 10 5 Day 1 Xopenex HFA Inhalation Aerosol (n=219) Racemic Albuterol HFA 180 mcg (n=119) Placebo (n=107) 0-1 0 1 2 3 4 5 6 Time (hours) 30 Day 56 Xopenex HFA Inhalation Aerosol (n=187) Mean % Change in FEV 1 25 20 15 10 5 Racemic Albuterol HFA 180 mcg (n=105) Placebo (n=95) 0-1 0 1 2 3 4 5 6 Time (hours) -

=be OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ ba ;Tl +& g[x `XW\Ta g\`x gb bafxg by T +/! \avextfx \a =<M + etazxw Yeb` /(/ gb +*(, `\ahgxf TaW g[x `XW\Ta g\`x gb cxt^ XYYXVg etazxw Yeb` 10 gb 12 `\ahgxf( @a g[x exfcbawxe cbch_tg\ba& ba ;Tl + g[x `XW\Ta WheTg\ba by XYYXVg Tf `XTfheXW Ul T +/! \avextfx \a =<M + jtf - gb. [bhef& j\g[ WheTg\ba by XYYXVg \a fb`x ctg\xagf by hc gb 0 [bhef( DQPUM^\UO]2 K[X XYY\VTVl TaW ftyxgl by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a V[\_WeXa jxex XfgTU_\f[XW \a T.'jXX^& `h_g\vxagxe& etawb`\mxw& WbhU_X'U_\aW& TVg\iX' TaW c_tvxub'vbageb XW ge\t_ \a +/* cxw\tge\v ctg\xagf j\g[ Tfg[`T UXgjXXa g[x TZXf by. TaW ++ lxtef( @a g[\f ge\t_& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ #10 ctg\xagf$ jtf Vb`cTeXW gb T c_tvxub?=7'+-.t D;@ #-/ ctg\xagf$& TaW g[x ge\t_ \av_hwxw T `Te^XgXW T_UhgXeb_?=7' +-.T D;@ #-3 ctg\xagf$ Tf Ta TVg\iX Vbageb_( JXe\T_ =<M + `XTfheX`Xagf WX`bafgeTgXW g[tg 3* `VZ #, \a[t_tg\baf$ by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ cebwhvxw f\za\y\vtag_l ZeXTgXe \`cebix`xag \a =<M + bixe g[x cexgextg`xag it_hx g[ta c_tvxub TaW jxex Vbaf\fgXag j\g[ g[x XYY\VTVl Y\aW\aZf \a g[x TWh_g fghw\xf( =be OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& ba ;Tl + g[x `XW\Ta g\`x gb bafxg by T +/! \avextfx \a =<M + jtf.(/ `\ahgxf TaW g[x `XW\Ta g\`x gb cxt^ XYYXVg jtf 11 `\ahgxf( @a g[x exfcbawxe cbch_tg\ba& g[x `XW\Ta WheTg\ba by XYYXVg Tf `XTfheXW Ul T +/! \avextfx \a =<M + jtf - [bhef& j\g[ T WheTg\ba by XYYXVg \a fb`x cxw\tge\v ctg\xagf by hc gb 0 [bhef( INDICATIONS AND USAGE OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ \f \aw\vtgxw Ybe g[x gextg`xag be cexixag\ba by UebaV[bfcTf` \a TWh_gf& TWb_XfVXagf& TaW V[\_WeXa. lxtef by TZX TaW b_wxe j\g[ exixef\u_x bufgehvg\ix T\ejTl W\fXTfX( CONTRAINDICATIONS OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ \f VbageT\aW\VTgXW \a ctg\xagf j\g[ T [\fgbel by [lcxefxaf\g\i\gl gb _XiT_UhgXeb_& etvx`\v T_UhgXeb_& be Tal bg[xe Vb`cbaXag by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( WARNINGS +( GTeTWbk\VT_ 8ebaV[bfcTf`4 C\^X bg[xe \a[t_xw UXgT'TWeXaXeZ\V TZba\fgf& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ VTa cebwhvx ctetwbk\vt_ UebaV[bfcTf`& j[\v[ `Tl UX _\YX' g[extgxa\az( @Y ctetwbk\vt_ UebaV[bfcTf` bvvhef& OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ f[bh_w UX W\fVbag\ahXW \``XW\TgX_l TaW T_gXeaTg\iX g[xetcl \afg\ghgxw( @g f[bh_w UX exvbza\mxw g[tg ctetwbk\vt_ UebaV[bfcTf`& j[xa TffbV\TgXW j\g[ \a[t_xw Ybe`h_Tg\baf& YeXdhXag_l bvvhef j\g[ g[x Y\efg hfx by T axj VTa\fgXe(,( ;XgXe\beTg\ba by 7fg[`T4 7fg[`T `Tl WXgXe\beTgX TVhgX_l bixe T cxe\bw by [bhef be V[eba\VT l bixe fxixet_ WTlf be _bazxe( @Y g[x ctg\xag axxwf `bex WbfXf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ g[ta hfht_& g[\f `Tl UX T `Te^Xe by WXfgTU\_\mTg\ba by Tfg[`T TaW exdh\exf exxit_htg\ba by g[x ctg\xag TaW gextg`xag.

exz\`xa& Z\i\aZ fcxv\t_ Vbaf\WXeTg\ba gb g[x cbff\u_x axxw Ybe Tag\'\aY_T``Tgbel gextg`xag& X(Z(& Vbeg\VbfgXeb\Wf( -( LfX by 7ag\'@aY_T``Tgbel 7ZXagf4 K[X hfx by T UXgT'TWeXaXeZ\V TZba\fg T_baX `Tl abg UX TWXdhTgX gb Vbageb_ Tfg[`T \a `Tal ctg\xagf( <Te_l Vbaf\WXeTg\ba f[bh_w UX Z\iXa gb TWW\aZ Tag\'\aY_T``Tgbel TZXagf& X(Z(& Vbeg\VbfgXeb\Wf& gb g[x g[xetcxhg\v exz\`xa(.( 9TeW\biTfVh_Te <YYXVgf4 OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& _\^X bg[xe UXgT' TWeXaXeZ\V TZba\fgf& VTa cebwhvx V_\a\VT l f\za\y\vtag VTeW\biTfVh_Te XYYXVgf \a fb`x ctg\xagf& Tf `XTfheXW Ul [XTeg etgx& U_bbW cexffhex& TaW)be fl`cgb`f( 7_g[bhZ[ fhv[ XYYXVgf TeX havb``ba TYgXe TW`\a\fgeTg\ba by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ Tg exvb``xawxw WbfXf& \Y g[xl bvvhe& g[x WehZ `Tl axxw gb UX W\fVbag\ahXW( @a TWW\g\ba& UXgT'TZba\fgf [TiX UXXa excbegxw gb cebwhvx X_XVgebVTeW\bZeT` #<9>$ V[TaZXf& fhv[ Tf Y_TggXa\aZ by g[x K jtix& ceb_baztg\ba by g[x HKV \agxeit_& TaW JK fxz`xag WXceXff\ba( K[X V_\a\VT_ f\za\y\vtavx by g[xfx Y\aW\aZf \f ha^abja( K[XeXYbeX& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& _\^X T fl`ctg[b`\`xg\v T`\aXf& f[bh_w UX hfxw j\g[ VThg\ba \a ctg\xagf j\g[ VTeW\biTfVh_Te W\fbeWXef& XfcXV\T l VbebaTel \afhyy\v\xavl& VTeW\TV Tee[lg[`\Tf& TaW [lcxegxaf\ba( /( ;b Ebg <kvxxw IXVb``XaWXW ;bfx4 =TgT_\g\Xf [TiX UXXa excbegxw \a TffbV\Tg\ba j\g[ XkVXff\iX hfx by \a[t_xw fl`ctg[b`\`xg\v WehZf \a ctg\xagf j\g[ Tfg[`T( K[X XkTVg VThfX by WXTg[ \f ha^abja& Uhg VTeW\TV TeeXfg Yb bj\az Ta haxkcxvgxw WXiX_bc`Xag by T fxixex TVhgX Tfg[`Tg\V Ve\f\f TaW fhufxdhxag [lcbk\t \f fhfcxvgxw( 0( @``XW\TgX?lcXefXaf\g\i\gl IXTVg\baf4 @``XW\TgX [lcxefxaf\g\i\gl extvg\baf `Tl bvvhe TYgXe TW`\a\fgeTg\ba by etvx`\v T_UhgXeb_& Tf WX`bafgeTgXW Ul etex VTfXf by heg\vte\t& TaZ\bXWX`T& etf[& UebaV[bfcTf`& TaTc[l_Tk\f& TaW bebc[telazxt_ XWX`T( K[X cbgxag\t_ Ybe [lcxefxaf\g\i\gl `hfg UX Vbaf\WXeXW \a g[x V_\a\VT_ XiT_hTg\ba by ctg\xagf j[b XkcXe\XaVX \``XW\TgX [lcxefxaf\g\i\gl extvg\baf j[\_x exvx\i\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( PRECAUTIONS General OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_& _\^X T fl`ctg[b`\`xg\v T`\aXf& f[bh_w UX hfxw j\g[ VThg\ba \a ctg\xagf j\g[ VTeW\biTfVh_Te W\fbeWXef& XfcXV\T l VbebaTel \afhyy\v\xavl& [lcxegxaf\ba& TaW VTeW\TV Tee[lg[`\Tf5 \a ctg\xagf j\g[ Vbaih_f\iX W\fbeWXef& [lcxeg[leb\w\f`& be W\TUXgXf `X \ghf5 TaW \a ctg\xagf j[b TeX hahfht l exfcbaf\ix gb fl`ctg[b`\`xg\v T`\aXf( 9_\a\VT l f\za\y\vtag V[TaZXf \a flfgb_\v TaW W\Tfgb_\V U_bbW cexffhex [TiX UXXa fxxa \a \aw\i\wht_ ctg\xagf TaW Vbh_W UX XkcXVgXW gb bvvhe \a fb`x ctg\xagf TYgXe g[x hfx by Tal UXgT'TWeXaXeZ\V UebaV[bW\_Tgbe( CTeZX WbfXf by \agetixabhf etvx`\v T_UhgXeb_ [TiX UXXa excbegxw gb TZZeTiTgX cexxk\fg\az W\TUXgXf `X \ghf TaW ^XgbTV\Wbf\f( 7f j\g[ bg[xe UXgT'TWeXaXeZ\V TZba\fg `XW\VTg\baf& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ `Tl cebwhvx f\za\y\vtag [lcb^t_x`\t \a fb`x ctg\xagf& cbff\u_l g[ebhz[ \agetvx h_te f[hag\az& j[\v[ [Tf g[x cbgxag\t_ gb cebwhvx /

TWiXefX VTeW\biTfVh_Te XYYXVgf( K[X WXVeXTfX \f hfht l getaf\xag& abg exdh\e\az fhcc_x`xagtg\ba( Information for Patients JXX \ hfgetgxw DM^UQY^d] >Y]^\_O^UZY] RZ\ H]Q' J?7B< N<CC 8<=FI< LJ@E>( GTg\Xagf f[bh_w UX Z\iXa g[x Yb bj\az \aybe`tg\ba4 @g \f exvb``xawxw gb ce\`x g[x \a[t_xe UXYbeX hf\az Ybe g[x Y\efg g\`x TaW \a VTfXf j[xex g[x \a[t_xe [Tf abg UXXa hfxw Ybe `bex g[ta - WTlf Ul ex_xtf\az. gxfg fcetlf \agb g[x T\e& TjTl Yeb` g[x YTVX( B<<G@E> K?< GC7JK@9 79KL7KFI 9C<7E @J M<IP @DGFIK7EK KF GI<M<EK D<;@97K@FE 8L@C;'LG 7E; 8CF9B7><( K?< 79KL7KFI J?FLC; 8< N7J?<;& J?7B<E KF I<DFM< <O9<JJ N7K<I& 7E; 7@I' ;I@<; K?FIFL>?CP 7K C<7JK FE9< 7 N<<B( K?< @E?7C<I D7P 9<7J< KF ;<C@M<I D<;@97K@FE @= EFK GIFG<ICP 9C<7E<;( K[X TVghTgbe f[bh_w UX V_XTaXW #j\g[ g[x VTa\fgXe ex`bixw$ Ul ehaa\az jte` jtgxe g[ebhz[ g[x gbc TaW Ubggb` Ybe -* fxvbawf Tg _XTfg bavx T jxx^( ;b abg TggX`cg gb V_XTa g[x `XgT_ VTa\fgXe be T bj g[x `XgT_ VTa\fgXe gb UXVb`X jxg( EXiXe \``XefX g[x `XgT_ VTa\fgXe \a jtgxe( K[X TVghTgbe `hfg UX f[t^xa gb ex`bix XkVXff jtgxe& g[xa T\e'We\XW g[bebhz[_l #fhv[ Tf bixea\z[g$( 8_bV^TZX Yeb` `XW\VTg\ba Uh\_W'hc be \`cebcxe `XW\VTg\ba WX_\iXel `Tl exfh_g Yeb` YT\_heX gb V_XTa TaW g[bebhz[_l T\e'Wel g[x TVghTgbe( @Y g[x TVghTgbe UXVb`Xf U_bV^XW #_\gg_x be ab `XW\VTg\ba Vb`\aZ bhg by g[x `bhg[c\xvx$& g[x U_bV^TZX `Tl UX ex`bixw Ul jtf[\az g[x TVghTgbe Tf WXfVe\UXW TUbiX( @Y \g \f axvxfftel gb hfx g[x \a[t_xe UXYbeX \g \f Vb`c_XgX_l Wel& f[t^x XkVXff jtgxe byy g[x c_tfg\v TVghTgbe& exc_tvx VTa\fgXe& f[t^x jx & gxfg'fcetl gj\vx TjTl Yeb` YTVX& TaW gt^x g[x cexfve\uxw WbfX( 7YgXe fhv[ hfx& g[x TVghTgbe f[bh_w UX exjtf[xw TaW T bjxw gb T\e' Wel g[bebhz[_l( K[X TVg\ba by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w _Tfg Ybe. gb 0 [bhef( OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w abg UX hfxw `bex YeXdhXag_l g[ta exvb``xawxw( ;b abg \avextfx g[x WbfX be YeXdhXaVl by WbfXf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ j\g[bhg Vbafh_g\aZ lbhe c[lf\v\ta( @Y lbh Y\aW g[tg gextg`xag j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ UXVb`Xf _Xff XYYXVg\iX Ybe fl`cgb`tg\v ex_\xy& lbhe fl`cgb`f UXVb`X jbefx& TaW)be lbh axxw gb hfx g[x cebwhvg `bex YeXdhXag_l g[ta hfht_& lbh f[bh_w fxx^ `XW\VT_ TggXag\ba \``XW\TgX_l( N[\_X lbh TeX hf\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& bg[xe \a[t_xw WehZf TaW Tfg[`T `XW\VTg\ba f[bh_w UX gt^xa ba_l Tf W\eXVgXW Ul lbhe c[lf\v\ta( 9b``ba TWiXefX XYYXVgf by gextg`xag j\g[ \a[t_xw UXgT'TZba\fgf \av_hwx ct_c\gtg\baf& V[Xfg ct\a& etc\w [XTeg etgx& gex`be& TaW axeibhfaxff( @Y lbh TeX cexzatag be ahef\az& VbagTVg lbhe c[lf\v\ta TUbhg hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( <YYXVg\iX TaW ftyx hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \av_hwxf Ta hawxefgtaw\az by g[x jtl g[tg \g f[bh_w UX TW`\a\fgXeXW( 0

LfX OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ ba_l j\g[ g[x TVghTgbe fhcc_\xw j\g[ g[x cebwhvg( ;\fvtew g[x VTa\fgXe TYgXe,** fcetlf [TiX UXXa hfxw Yeb` g[x +/ Z VTa\fgXe be TYgXe 2* fcetlf [TiX UXXa hfxw Yeb` g[x 2(. Z VTa\fgXe( EXiXe \``XefX g[x VTa\fgXe \a jtgxe gb WXgXe`\aX [bj Yh g[x VTa\fgXe \f #oy_btg gxfgp$( @a ZXaXeT_& g[x gxv[a\dhx Ybe TW`\a\fgXe\aZ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ gb V[\_WeXa \f f\`\_te gb g[tg Ybe TWh_gf( 9[\_WeXa f[bh_w hfx OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ hawxe TWh_g fhcxei\f\ba& Tf \afgehvgxw Ul g[x ctg\xagnf c[lf\v\ta( #JXX DM^UQY^d] >Y]^\_O^UZY] RZ\ H]Q'$ Drug Interactions Fg[Xe f[beg'tvg\az fl`ctg[b`\`xg\v TXebfb_ UebaV[bW\_Tgbef be Xc\aXc[e\aX f[bh_w UX hfxw j\g[ VThg\ba j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( @Y TWW\g\baT_ TWeXaXeZ\V WehZf TeX gb UX TW`\a\fgXeXW Ul Tal ebhgx& g[xl f[bh_w UX hfxw j\g[ VThg\ba gb Tib\W WX_XgXe\bhf VTeW\biTfVh_Te XYYXVgf( +( 8XgT'U_bV^Xef4 8XgT'TWeXaXeZ\V exvxcgbe U_bV^\aZ TZXagf abg ba_l U_bV^ g[x ch_`batel XYYXVg by UXgT'TWeXaXeZ\V TZba\fgf& fhv[ Tf OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& Uhg `Tl cebwhvx fxixex UebaV[bfcTf` \a Tfg[`Tg\V ctg\xagf( K[XeXYbeX& ctg\xagf j\g[ Tfg[`T f[bh_w abg abe`t l UX gextgxw j\g[ UXgT'U_bV^Xef(?bjXiXe& hawxe VXegT\a V\eVh`fgTaVXf& X(Z(& Tf cebc[l_tk\f TYgXe `lbvtew\t_ \aytevg\ba& g[xex `Tl UX ab TVVXcgTU_X T_gXeaTg\iXf gb g[x hfx by UXgT'TWeXaXeZ\V U_bV^\aZ TZXagf \a ctg\xagf j\g[ Tfg[`T( @a g[\f fxgg\az& VTeW\bfX_XVg\iX UXgT'U_bV^Xef f[bh_w UX Vbaf\WXeXW& T_g[bhZ[ g[xl f[bh_w UX TW`\a\fgXeXW j\g[ VThg\ba(,( ;\hexg\vf4 K[X <9> V[TaZXf TaW)be [lcb^t_x`\t g[tg `Tl exfh_g Yeb` g[x TW`\a\fgeTg\ba by abaqcbgtff\h`'fcte\az W\heXg\Vf #fhv[ Tf _bbc TaW g[\tm\wx W\heXg\Vf$ VTa UX TVhgX_l jbefxaxw Ul UXgT'TZba\fgf& XfcXV\T l j[xa g[x exvb``xawxw WbfX by g[x UXgT'TZba\fg \f XkVXXWXW( 7_g[bhZ[ g[x V_\a\VT_ f\za\y\vtavx by g[xfx XYYXVgf \f abg ^abja& VThg\ba \f TWi\fXW \a g[x VbTW`\a\fgeTg\ba by UXgT'TZba\fgf j\g[ abaqcbgtff\h`'fcte\az W\heXg\Vf( -( ;\Zbk\a4 DXTa WXVeXTfXf by +0! gb,,! \a fxeh` W\Zbk\a _XiX_f jxex WX`bafgeTgXW TYgXe f\az_x'wbfx \agetixabhf TaW bet_ TW`\a\fgeTg\ba by etvx`\v T_UhgXeb_& exfcxvg\ix_l& gb abe`t_ ib_hagxxef j[b [TW exvx\ixw W\Zbk\a Ybe +* WTlf( K[X V_\a\VT_ f\za\y\vtavx by g[xfx Y\aW\aZf Ybe ctg\xagf j\g[ bufgehvg\ix T\ejTl W\fXTfX j[b TeX exvx\i\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ TaW W\Zbk\a ba T V[eba\V UTf\f \f hav_xte( EXiXeg[X_Xff& \g jbh_w UX cehwxag gb VTeXYh l XiT_hTgX g[x fxeh` W\Zbk\a _XiX_f \a ctg\xagf j[b TeX VheeXag_l exvx\i\az W\Zbk\a TaW OFG<E<O?=7 @a[t_tg\ba 7Xebfb_(.( DbabT`\aX Fk\WTfX @a[\u\gbef be Ke\VlV_\V 7ag\WXceXffTagf4 OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w UX TW`\a\fgXeXW j\g[ XkgeX`X VThg\ba gb ctg\xagf UX\aZ gextgxw j\g[ `babt`\ax bk\wtfx \a[\u\gbef be ge\vlv_\v Tag\WXceXffTagf& be j\g[\a, jxx^f by W\fVbag\ahTg\ba by fhv[ TZXagf& UXVThfX g[x TVg\ba by T_UhgXeb_ ba g[x itfvh_te flfgx` `Tl UX cbgxag\tgxw( 1

Carcinogenesis, Mutagenesis, and Impairment of Fertility Eb VTeV\abZXaXf\f be \`ct\e`xag by YXeg\_\gl fghw\xf [TiX UXXa VTee\XW bhg j\g[ _XiT_UhgXeb_ gtegetgx(?bjxixe& etvx`\v T_UhgXeb_ fh_ytgx [Tf UXXa XiT_hTgXW Ybe \gf VTeV\abZXa\V cbgxag\t_ TaW TU\_\gl gb \`ct\e YXeg\_\gl( @a T,'lXTe fghwl \a JceTZhX';Tj_Xl etgf& etvx`\v T_UhgXeb_ fh_ytgx VThfXW T f\za\y\vtag WbfX'eX_TgXW \avextfx \a g[x \av\wxavx by UXa\Za _X\b`lb`Tf by g[x `XfbiTe\h` Tg& TaW TUbiX& W\XgTel WbfXf by, `Z)^Z)WTl #Tccebk\`TgX_l -* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l +/ g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe V[\_WeXa ba T `Z)`, UTf\f$( @a Tabg[Xe fghwl& g[\f XYYXVg jtf U_bV^XW Ul g[x VbTW`\a\fgeTg\ba by cebcetab_b_& T abafx_xvg\ix UXgT'TWeXaXeZ\V TagTZba\fg( @a Ta +2'`bag[ fghwl \a 9;'+ `\VX& etvx`\v T_UhgXeb_ fh_ytgx f[bjxw ab Xi\WXaVX by gh`be\zxa\v\gl Tg W\XgTel WbfXf hc gb /** `Z)^Z)WTl #Tccebk\`TgX_l -2** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l +2** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe V[\_WeXa ba T `Z)`, UTf\f$( @a T,,'`bag[ fghwl \a g[x >b_wxa [T`fgXe& etvx`\v T_UhgXeb_ fh_ytgx f[bjxw ab Xi\WXaVX by gh`be\zxa\v\gl Tg W\XgTel WbfXf hc gb /* `Z)^Z)WTl #Tccebk\`TgX_l /** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l,.* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe V[\_WeXa ba T `Z)`, UTf\f$( CXiT_UhgXeb_?9_ jtf abg `hgtzxa\v \a g[x 7`Xf gxfg be g[x 9?F)?GIK DT``T_\Ta =bejtew >XaX DhgTg\ba 7ffTl( CXiT_UhgXeb_?9_ jtf abg V_TfgbZXa\V \a g[x \a i\ib `\VebahV_Xhf gxfg \a `bhfx UbaX `Teebj( ITVX`\V T_UhgXeb_ fh_ytgx jtf axztg\ix \a Ta \a i\geb V[eb`bfb`T_ TUXeeTg\ba TffTl \a 9?F VX Vh_gheXf( IXcebWhVg\ba fghw\xf \a etgf hf\az etvx`\v T_UhgXeb_ fh_ytgx WX`bafgeTgXW ab Xi\WXaVX by \`ct\exw YXeg\_\gl Tg bet_ WbfXf hc gb /* `Z)^Z)WTl #Tccebk\`TgX_l 1/* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f$( Teratogenic Effects - Pregnancy Category C 7 excebwhvg\ba fghwl \a EXj QXT_TaW N[\gX etuu\gf WX`bafgeTgXW g[tg _XiT_UhgXeb_?9_ jtf abg gxetgbzxa\v j[xa TW`\a\fgXeXW bet l Tg WbfXf hc gb,/ `Z)^Z)WTl #Tccebk\`TgX_l 1/* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f$(?bjXiXe& etvx`\v T_UhgXeb_ fh_ytgx [Tf UXXa f[bja gb UX gxetgbzxa\v \a `\VX TaW etuu\gf( 7 fghwl \a 9;'+ `\VX Z\iXa etvx`\v T_UhgXeb_ fh_ytgx fhuvhgtaxbhf_l f[bjxw V_XYg ct_tgx Ybe`Tg\ba \a / by +++ #.(/!$ YXghfXf Tg *(,/ `Z)^Z)WTl #Tccebk\`TgX_l, g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f$ TaW \a +* by +*2 #3(-!$ YXghfXf Tg,(/ `Z)^Z)WTl #Tccebk\`TgX_l,* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T )(

`Z)`, UTf\f$( K[X WehZ W\W abg \awhvx V_XYg ct_tgx Ybe`Tg\ba j[xa TW`\a\fgXeXW fhuvhgtaxbhf_l Tg T WbfX by *(*,/ `Z)^Z)WTl #_Xff g[ta g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f$( 9_XYg ct_tgx T_fb bvvheexw \a,, by 1, #-*(/!$ YXghfXf Yeb` YX`T_Xf gextgxw fhuvhgtaxbhf_l j\g[,(/ `Z)^Z)WTl by \fbcebgxexab_ #cbf\g\ix Vbageb_$( 7 excebwhvg\ba fghwl \a Jge\WX ;hgv[ etuu\gf exixt_xw VeTa\bfV[\f\f \a 1 by +3 #-1!$ YXghfXf j[xa etvx`\v T_UhgXeb_ fh_ytgx jtf TW`\a\fgXeXW bet l Tg T WbfX by /* `Z)^Z)WTl #Tccebk\`TgX_l +/** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f$( 7 fghwl \a j[\v[ cexzatag etgf jxex WbfXW j\g[ etw\b_tux_xw etvx`\v T_UhgXeb_ fh_ytgx WX`bafgeTgXW g[tg WehZ'eX_TgXW `TgXe\T_ \f getafyxeexw Yeb` g[x `TgXeaT_ V\eVh_Tg\ba gb g[x YXghf( K[XeX TeX ab TWXdhTgX TaW jx 'Vbageb XW fghw\xf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a cexzatag jb`xa( 8XVThfX Ta\`T_ excebwhvg\ba fghw\xf TeX abg T_jTlf cexw\vg\ix by [h`ta exfcbafx& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w UX hfxw Whe\aZ cexzatavl ba_l \Y g[x cbgxag\t_ UXaXY\g ]hfg\y\xf g[x cbgxag\t_ e\f^ gb g[x YXghf( ;he\az `Te^Xg\aZ XkcXe\XaVX by etvx`\v T_UhgXeb_& ite\bhf VbaZXa\gT_ Tab`T_\Xf& \av_hw\az V_XYg ct_tgx TaW _\`U WXYXVgf& [TiX UXXa etex_l excbegxw \a g[x byyfce\az by ctg\xagf UX\aZ gextgxw j\g[ etvx`\v T_UhgXeb_( Jb`X by g[x `bg[xef jxex gt^\az `h_g\c_x `XW\VTg\baf Whe\aZ g[x\e cexzatav\xf( Eb Vbaf\fgXag ctggxea by WXYXVgf VTa UX W\fVXeaXW& TaW T ex_tg\baf[\c UXgjXXa etvx`\v T_UhgXeb_ hfx TaW VbaZXa\gT_ Tab`T_\Xf [Tf abg UXXa XfgTU_\f[XW( Use in Labor and Delivery 8XVThfX by g[x cbgxag\t_ Ybe UXgT'TWeXaXeZ\V TZba\fgf gb \agxeyxex j\g[ hgxe\ax VbageTVg\_\gl& g[x hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ Ybe g[x gextg`xag by UebaV[bfcTf` Whe\aZ _TUbe f[bh_w UX exfge\vgxw gb g[bfx ctg\xagf \a j[b` g[x UXaXY\gf V_XTe_l bhgjx\z[ g[x e\f^( Tocolysis OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ [Tf abg UXXa TccebiXW Ybe g[x `TaTZX`Xag by cexgxe` _TUbe( K[X UXaXY\g4e\f^ etg\b j[xa _XiT_UhgXeb_ gtegetgx \f TW`\a\fgXeXW Ybe gbvb_lf\f [Tf abg UXXa XfgTU_\f[XW( JXe\bhf TWiXefX extvg\baf& \av_hw\az `TgXeaT_ ch_`batel XWX`T& [TiX UXXa excbegxw Whe\aZ be Yb bj\az gextg`xag by cex`tghex _TUbe j\g[ UXgT, 'TZba\fgf& \av_hw\az etvx`\v T_UhgXeb_( Nursing Mothers G_Tf`T VbaVXageTg\baf by _XiT_UhgXeb_ TYgXe \a[t_tg\ba by g[xetcxhg\v WbfXf TeX ixel _bj \a [h`taf( @g \f abg ^abja j[xg[xe _XiT_UhgXeb_ \f XkVeXgXW \a [h`ta `\_^( ))

8XVThfX by g[x cbgxag\t_ Ybe gh`be\zxa\v\gl f[bja Ybe etvx`\v T_UhgXeb_ \a Ta\`T_ fghw\xf TaW g[x _TV^ by XkcXe\XaVX j\g[ g[x hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ Ul ahef\az `bg[xef& T WXV\f\ba f[bh_w UX `TWX j[xg[xe gb W\fVbag\ahX ahef\az be gb W\fVbag\ahX g[x WehZ& gt^\az \agb TVVbhag g[x \`cbegtavx by g[x WehZ gb g[x `bg[xe( 9Thg\ba f[bh_w UX XkXeV\fXW j[xa OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \f TW`\a\fgXeXW gb T ahef\az jb`ta( Pediatrics K[X ftyxgl TaW XYY\VTVl by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ [TiX UXXa XfgTU_\f[XW \a cxw\tge\v ctg\xagf. lxtef by TZX TaW b_wxe \a Ta TWXdhTgX TaW jx 'Vbageb XW V_\a\VT_ ge\t_ #fxx 7WUYUOMW G\UMW]$( LfX by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a V[\_WeXa \f T_fb fhccbegxw Ul Xi\WXaVX Yeb` TWXdhTgX TaW jx 'Vbageb XW fghw\xf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a TWh_gf& Vbaf\WXe\aZ g[tg g[x ctg[bc[lf\b_bzl& flfgx`\v XkcbfheX by g[x WehZ& TaW V_\a\VT_ ceby\_x \a cxw\tge\v TaW TWh_g ctg\xagf TeX fhufgtag\t l f\`\_te( JTYXgl TaW XYYXVg\iXaXff by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a cxw\tge\v ctg\xagf UX_bj g[x TZX by. lxtef [TiX abg UXXa XfgTU_\f[XW( Geriatrics 9_\a\VT_ fghw\xf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ W\W abg \av_hwx fhyy\v\xag ah`uxef by fhu]xvgf TZXW 0/ TaW b_wxe gb WXgXe`\aX j[xg[xe g[xl exfcbaw W\YYXeXag_l Yeb` lbhazxe fhu]xvgf( Fg[Xe excbegxw V_\a\VT_ XkcXe\XaVX [Tf abg \WXag\Y\XW W\YYXeXaVXf \a exfcbafxf UXgjXXa g[x X_WXe_l TaW lbhazxe ctg\xagf( @a ZXaXeT_& WbfX fx_xvg\ba Ybe Ta X_WXe_l ctg\xag f[bh_w UX VThg\bhf& hfht l fgteg\az Tg g[x _bj XaW by g[x Wbf\aZ etazx& exy_xvg\az g[x ZeXTgXe YeXdhXaVl by WXVeXTfXW [XcTg\V& exat_& be VTeW\TV YhaVg\ba& TaW by VbaVb`\gTag W\fXTfXf be bg[xe WehZ g[xetcl( 7_UhgXeb_ \f ^abja gb UX fhufgtag\t l XkVeXgXW Ul g[x ^\WaXl& TaW g[x e\f^ by gbk\v extvg\baf `Tl UX ZeXTgXe \a ctg\xagf j\g[ \`ct\exw exat_ YhaVg\ba( 8XVThfX X_WXe_l ctg\xagf TeX `bex _\^X_l gb [TiX WXVeXTfXW exat_ YhaVg\ba& VTeX f[bh_w UX gt^xa \a WbfX fx_xvg\ba& TaW \g `Tl UX hfxyh_ gb `ba\gbe exat_ YhaVg\ba( ADVERSE REACTIONS 7WiXefX XiXag \aybe`tg\ba VbaVXea\aZ OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ \a TWh_gf TaW TWb_XfVXagf \f WXe\iXW Yeb` gjb 2'jXX^& `h_g\vxagxe& etawb`\mxw& WbhU_X'U_\aW& TVg\iX' TaW c_tvxub'vbageb XW ge\t_f \a 1.2 TWh_g TaW TWb_XfVXag ctg\xagf j\g[ Tfg[`T g[tg Vb`cTeXW OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& T `Te^XgXW T_UhgXeb_?=7 \a[t_xe& TaW Ta?=7'+-.T c_tvxub \a[t_xe( KTU_X, _\fgf g[x \av\wxavx by T TWiXefX XiXagf #j[xg[xe Vbaf\WXeXW Ul g[x \aixfg\ztgbe gb UX ex_tgxw be haex_tgxw gb WehZ$ Yeb` g[xfx ge\t_f g[tg bvvheexw Tg T etgx by,! be ZeXTgXe \a g[x Zebhc gextgxw j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ TaW `bex YeXdhXag_l g[ta \a g[x?=7'+-.t c_tvxub \a[t_xe Zebhc( )*

GMNWQ *2 6ZPb Fb]^QX D\QRQ\\QP GQ\X 8bWl Tf T N[b_X 5P`Q\]Q 9`QY^ >YOUPQYOQ "! ZR DM^UQY^]# UY GaZ 0&JQQV 7WUYUOMW G\UMW] UY 5P_W^] MYP 5PZWQ]OQY^] " )* LQM\] ZR 5SQ$ KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW 1( XOS "Y4,(+# EMOQXUO 5WN_^Q\ZW =;5 )0( XOS "Y4)/1# DWMOQNZ "Y4)..# GT\a.(* -(. -(0 9XageT_ EXeibhf JlfgX` ;\mm\axff,(1 *(0 +(2 IXfc\eTgbel JlfgX` 7fg[`T 3(. 1(- 0(* G[TelaZ\g\f 1(3,(,,(. I[\a\g\f 1(.,(, -(* % K[\f gtu_x \av_hwxf T TWiXefX XiXagf #j[xg[xe Vbaf\WXeXW Ul g[x \aixfg\ztgbe gb UX ex_tgxw be haex_tgxw gb WehZ$ Yeb` g[xfx ge\t_f g[tg bvvheexw Tg T etgx by,! be ZeXTgXe \a g[x Zebhc gextgxw j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ TaW `bex YeXdhXag_l g[ta \a g[x?=7'+-.t c_tvxub \a[t_xe Zebhc( 7WiXefX XiXagf excbegxw Ul _Xff g[ta,! TaW Tg _XTfg, be `bex by g[x TWb_XfVXag TaW TWh_g ctg\xagf exvx\i\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ TaW Ul T ZeXTgXe cebcbeg\ba g[ta exvx\i\az?=7'+-.t c_tvxub \a[t_xe \av_hwx Vlfg& Y_h flaweb`x& i\et_ \ayxvg\ba& Vbafg\cTg\ba& ZTfgebXagXe\g\f& `lt_z\t& [lcxegxaf\ba& Xc\fgTk\f& _haz W\fbeWXe& TVaX& [XecXf f\`c_xk& Vba]haVg\i\g\f& XTe ct\a& Wlf`Xabee[XT& [X`Tghe\T& TaW itz\at_ `ba\_\tf\f( K[XeX jxex ab f\za\y\vtag _TUbeTgbel TUabe`T_\g\Xf bufxeixw \a g[xfx fghw\xf( 7WiXefX XiXag \aybe`tg\ba VbaVXea\aZ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a V[\_WeXa \f WXe\iXW Yeb` T.'jXX^& etawb`\mxw& WbhU_X'U_\aW ge\t_ by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& T `Te^XgXW T_UhgXeb_?=7 \a[t_xe& TaW Ta?=7'+-.T c_tvxub \a[t_xe \a +/* V[\_WeXa TZXW. gb ++ lxtef j\g[ Tfg[`T( KTU_X - _\fgf g[x TWiXefX XiXagf excbegxw Ybe OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \a V[\_WeXa Tg T etgx by,! be ZeXTgXe TaW `bex YeXdhXag_l g[ta Ybe c_tvxub( )+

GMNWQ +2 6ZPb Fb]^QX 5P`Q\]Q 9`QY^ >YOUPQYOQ "! ZR DM^UQY^]# UY M,&JQQV G\UMW UY 7TUWP\QY 5SQP,&)) LQM\]$ D\QRQ\\QP GQ\X 8bWl Tf T N[b_X KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW 1( XOS "Y4/.# EMOQXUO 5WN_^Q\ZW =;5 )0( XOS "Y4+1# DWMOQNZ "Y4+-# 7VV\WXagT_ \a]hel 3(, +*(- /(1 ;\ZXfg\iX JlfgX` Mb`\g\aZ +*(/ 1(1 /(1 IXfc\eTgbel JlfgX` 8ebaV[\g\f,(0 * * G[TelaZ\g\f 0(0 +,(2 /(1 % K[\f gtu_x \av_hwxf T TWiXefX XiXagf #j[xg[xe Vbaf\WXeXW Ul g[x \aixfg\ztgbe gb UX ex_tgxw be haex_tgxw gb WehZ$ Yeb` g[x ge\t_ g[tg bvvheexw Tg T etgx by,! be ZeXTgXe \a g[x Zebhc gextgxw j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ TaW `bex YeXdhXag_l g[ta \a g[x?=7'+-.t c_tvxub \a[t_xe Zebhc( K[X \av\wxavx by flfgx`\v UXgT'TWeXaXeZ\V TWiXefX XYYXVgf #X(Z(& gex`be& axeibhfaxff$ jtf _bj TaW Vb`cTeTU_X TVebff T gextg`xag Zebhcf& \av_hw\az c_tvxub( Postmarketing @a TWW\g\ba gb g[x TWiXefX XiXagf excbegxw \a V_\a\VT_ ge\t_f& g[x Yb bj\az TWiXefX XiXagf [TiX UXXa bufxeixw \a cbfgtccebit_ hfx by _XiT_UhgXeb_ \a[t_tg\ba fb_hg\ba( K[XfX XiXagf [TiX UXXa V[bfXa Ybe \av_hf\ba WhX gb g[x\e fxe\bhfaxff& g[x\e YeXdhXaVl by excbeg\az& be g[x\e _\^X_l UXgT'`XW\TgXW `XV[Ta\f`4 TaZ\bXWX`T& TaTc[l_Tk\f& Tee[lg[`\Tf #\av_hw\az Tge\T_ Y\Ue\ Tg\ba& fhcetixage\vh_te gtv[lvtew\t& XkgeTflfgb_Xf$& Tfg[`T& V[Xfg ct\a& VbhZ[ \avextfxw& WlfcaXT& athfxt& axeibhfaxff& etf[& gtv[lvtew\t& gex`be& heg\vte\t( 8XVThfX g[xfx XiXagf [TiX UXXa excbegxw fcbagtaxbhf_l Yeb` T cbch_tg\ba by ha^abja f\mx& Xfg\`TgXf by YeXdhXaVl VTaabg UX `TWX( @a TWW\g\ba& OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& _\^X bg[xe fl`ctg[b`\`xg\v TZXagf& VTa VThfX TWiXefX extvg\baf fhv[ Tf [lcxegxaf\ba& TaZ\aT& ixeg\zb& VXageT_ axeibhf flfgx` fg\`h_tg\ba& f_xxc_xffaxff& [XTWTV[X& TaW Wel\aZ be \ee\gtg\ba by g[x bebc[telak( OVERDOSAGE K[X XkcXVgXW fl`cgb`f j\g[ bixewbftzx TeX g[bfx by XkVXff\iX UXgT'TWeXaXeZ\V exvxcgbe fg\`h_tg\ba TaW)be bvvheexavx be XkTZZXeTg\ba by Tal by g[x fl`cgb`f _\fgxw hawxe 7;M<IJ< I<79K@FEJ& X(Z(& fx\mhexf& TaZ\aT& [lcxegxaf\ba be [lcbgxaf\ba& gtv[lvtew\t j\g[ etgxf hc gb,** UXTgf)`\ahgX& Tee[lg[`\Tf& axeibhfaxff& [XTWTV[X& gex`be& Wel `bhg[& ct_c\gtg\ba& athfxt& W\mm\aXff& YTg\ZhX& `T_T\fX& TaW f_xxc_xffaxff(?lcb^t_x`\t T_fb `Tl bvvhe( 7f j\g[ T fl`ctg[b`\`xg\v `XW\VTg\baf& VTeW\TV TeeXfg ),

TaW XiXa WXTg[ `Tl UX TffbV\TgXW j\g[ g[x TUhfX by OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_( KeXTg`Xag Vbaf\fgf by W\fVbag\ahTg\ba by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ gbzxg[xe j\g[ Tccebce\TgX fl`cgb`tg\v g[xetcl( K[X ]hw\v\bhf hfx by T VTeW\bfX_XVg\iX UXgT'eXVXcgbe U_bV^Xe `Tl UX Vbaf\WXeXW& UXTe\aZ \a `\aw g[tg fhv[ `XW\VTg\ba VTa cebwhvx UebaV[bfcTf`( K[XeX \f \afhyy\v\xag Xi\WXaVX gb WXgXe`\aX \Y W\T_lf\f \f UXaXY\V\T_ Ybe bixewbftzx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( =b bj\az \agetixabhf TW`\a\fgeTg\ba \a `\VX& g[x `XW\Ta _Xg[T XiT_UhgXeb_?9_ WbfX jtf Tccebk\`TgX_l 00 `Z)^Z #Tccebk\`TgX_l /** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l,-* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe cxw\tge\v ctg\xagf ba T `Z)`, UTf\f$( =b bj\az \agetixabhf TW`\a\fgeTg\ba \a etgf& g[x `XW\Ta _Xg[T XiT_UhgXeb_?9_ WbfX jtf Tccebk\`TgX_l 0* `Z)^Z #Tccebk\`TgX_l 3** g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l.-* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe V[\_WeXa ba T `Z)`, UTf\f$( K[X \a[t_tg\ba `XW\Ta _Xg[T_ WbfX [Tf abg UXXa WXgXe`\aXW \a Ta\`T_f( @a WbZf& \a[t_xw WbfXf by _XiT_UhgXeb_?9_ hc gb,(1- `Z)^Z #Tccebk\`TgX_l +.* g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe TWh_gf ba T `Z)`, UTf\f TaW Tccebk\`TgX_l 0/ g\`xf g[x `Tk\`h` exvb``xawxw WT\_l \a[t_tg\ba WbfX by _XiT_UhgXeb_ gtegetgx Ybe V[\_WeXa ba T `Z)`, UTf\f$ jxex gb_xetgxw j\g[bhg Ta\`T_ WXTg[f( DOSAGE AND ADMINISTRATION 5P_W^ MYP DQPUM^\UO 5]^TXM2 =be gextg`xag by TVhgX Xc\fbWXf by UebaV[bfcTf` be cexixag\ba by Tfg[`Tg\V fl`cgb`f& g[x hfht_ WbfTZX by OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ Ybe TWh_gf TaW V[\_WeXa. lxtef by TZX TaW b_wxe \f, \a[t_tg\baf #3* `VZ$ excxtgxw XiXel. gb 0 [bhef5 \a fb`x ctg\xagf& + \a[t_tg\ba XiXel. [bhef `Tl UX fhyy\v\xag( DbeX YeXdhXag TW`\a\fgeTg\ba be T _TeZXe ah`uxe by \a[t_tg\baf \f abg ebhg\ax_l exvb``xawxw( @g \f exvb``xawxw gb ce\`x g[x \a[t_xe UXYbeX hf\az Ybe g[x Y\efg g\`x TaW \a VTfXf j[xex g[x \a[t_xe [Tf abg UXXa hfxw Ybe `bex g[ta - WTlf Ul ex_xtf\az. gxfg fcetlf \agb g[x T\e& TjTl Yeb` g[x YTVX( @Y T cexi\bhf_l XYYXVg\iX WbfTZX exz\`xa YT\_f gb cebi\wx g[x hfht_ exfcbafx& g[\f `Tl UX T `Te^Xe by WXfgTU\_\mTg\ba by Tfg[`T TaW exdh\exf exxit_htg\ba by g[x ctg\xag TaW g[x gextg`xag exz\`xa& Z\i\aZ fcxv\t_ Vbaf\WXeTg\ba gb g[x cbff\u_x axxw Ybe Tag\' \ay_t``tgbel gextg`xag& X(Z(& Vbeg\VbfgXeb\Wf( 7WQMYUYS2 Kb `T\agT\a cebcxe hfx by g[\f cebwhvg& \g \f Ve\g\VT_ g[tg g[x TVghTgbe UX jtf[xw TaW We\XW g[bebhz[_l Tg _XTfg bavx T jxx^( K[X \a[t_xe `Tl VXTfX gb WX_\iXe `XW\VTg\ba \Y abg cebcxe_l V_XTaXW TaW We\XW g[bebhz[_l( JXX >YRZ\XM^UZY RZ\ DM^UQY^]( BXXc\aZ g[x c_tfg\v TVghTgbe V_XTa \f ixel \`cbegtag gb cexixag `XW\VTg\ba Uh\_W'hc TaW U_bV^TZX( @Y g[x TVghTgbe UXVb`Xf U_bV^XW j\g[ WehZ& jtf[\az g[x TVghTgbe j\ ex`bix g[x U_bV^TZX( )-

HOW SUPPLIED OFG<E<O?=7 #_XiT_UhgXeb_ gtegetgx$ @a[t_tg\ba 7Xebfb_ \f fhcc_\xw Tf T cexffhe\mxw T_h`\ah` VTa\fgXe \a T Ubk #E;9 0-.*,'/+*'*+ be E;9 0-.*,'/+*'*.$( K[X VTa\fgXe \f _TUX_XW j\g[ T axg jx\z[g by +/ Z be 2(. Z TaW VbagT\af,** `XgXeXW TVghTg\baf be 2* `XgXeXW TVghTg\baf #be \a[t_tg\baf$& exfcxvg\ix_l( <TV[ VTa\fgXe \f fhcc_\xw j\g[ T U_hX c_tfg\v TVghTgbe #be `bhg[c\xvx$& T exw `bhg[c\xvx VTc& TaW ctg\xagnf \afgehvg\baf( J?7B< N<CC 8<=FI< LJ@E>( JgbeX UXgjXXa,*t TaW,/t9 #02t TaW 11t=5 fxx LJG Vbageb XW ebb` gx`cxetghex$( GebgXVg Yeb` YeXXm\aZ gx`cxetghexf TaW W\eXVg fha_\z[g( JgbeX \a[t_xe j\g[ g[x TVghTgbe #be `bhg[c\xvx$ Wbja( 7ib\W fcetl\az \a XlXf( 9bagXagf hawxe cexffhex( ;b abg chavghex be \av\axetgx( <kcbfhex gb gx`cxetghexf TUbiX +,*t= `Tl VThfX Uhefg\aZ( BXXc bhg by extv[ by V[\_WeXa( K[X U_hX TVghTgbe fhcc_\xw j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w abg UX hfxw j\g[ Tal bg[xe cebwhvg VTa\fgXef( 7VghTgbef Yeb` bg[xe cebwhvgf f[bh_w abg UX hfxw j\g[ T OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ VTa\fgXe( K[X VbeeXVg T`bhag by `XW\VTg\ba \a XTV[ TVghTg\ba VTaabg UX TffheXW TYgXe,** TVghTg\baf Yeb` g[x +/ Z VTa\fgXe be 2* TVghTg\baf Yeb` g[x 2(. Z VTa\fgXe& XiXa g[bhz[ g[x VTa\fgXe \f abg Vb`c_XgX_l X`cgl( K[X VTa\fgXe f[bh_w UX W\fVTeWXW j[xa,** TVghTg\baf [TiX UXXa hfxw Yeb` g[x +/ Z VTa\fgXe be 2* TVghTg\baf [TiX UXXa hfxw Yeb` g[x 2(. Z VTa\fgXe( OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ WbXf abg VbagT\a V[_bebY_hbebVTeUbaf #9=9f$ Tf g[x cebcx Tag( Ik ba_l( DTahYTVgheXW Ybe4 FQ[\MOZ\ >YO' DTe_UbebhZ[& D7 *+1/, LJ7 Ul -D ;ehz ;X_\iXel JlfgX`f Ebeg[e\WZX& 97 3+-,.'-,+- =be Vhfgb`Xe fxei\vx& VT +'222'-3.'1-11( Kb excbeg TWiXefX XiXagf& VT +'211'1-1'1,,0( =be `XW\VT_ \aybe`tg\ba& VT +'2**'1-3'*/0/( 7hZhfg,**0 OOOOOO ).

G?7ID79@JK r ;<K79??<I< 7E; >@M< @EJKIL9K@FEJ KF G7K@<EK( ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''' PATIENT S INSTRUCTIONS FOR USE KCD9B9K =;5e "WQ`MWN_^Q\ZW ^M\^\M^Q# >YTMWM^UZY 5Q\Z]ZW ;Z\ C\MW >YTMWM^UZY CYWb 6QRZ\Q _]UYS bz_\ KCD9B9K =;5 "WQ`MWN_^Q\ZW ^M\^\M^Q# >YTMWM^UZY 5Q\Z]ZW% \QMP ^TQ OZX[WQ^Q UY]^\_O^UZY] OM\QR_WWb' 56CHG KCD9B9K =;5 >B=5@5G>CB 59ECFC@ H]Q ZYWb M] PU\QO^QP Nb M PZO^Z\' 7TUWP\QY ]TZ_WP _]Q KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW _YPQ\ MP_W^ ]_[Q\`U]UZY% M] UY]^\_O^QP Nb ^TQ [M^UQY^d] PZO^Z\' KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW U] M [\Q]]_\UcQP XQ^Q\QP&PZ]Q UYTMWQ\ ^TM^ [\ZP_OQ] MY MQ\Z]ZW RZ\ Z\MW UYTMWM^UZY' KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW PZQ] YZ^ OZY^MUY OTWZ\ZRW_Z\ZOM\NZY] "7;7]#' GTQ NW_Q MO^_M^Z\ "Z\ XZ_^T[UQOQ# ]_[[WUQP au^t KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW ]TZ_WP YZ^ NQ _]QP au^t MYb Z^TQ\ [\ZP_O^ OMYU]^Q\]' 5O^_M^Z\] R\ZX Z^TQ\ [\ZP_O^] ]TZ_WP YZ^ NQ _]QP au^t M KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW OMYU]^Q\' =CJ GC HF9 LCHE KCD9B9K =;5 >B=5@5G>CB 59ECFC@ )' F=5?9 G=9 >B=5@9E J9@@ \``XW\TgX_l UXYbeX XTV[ hfx( *' E9ACI9 G=9 75D ;ECA G=9 57GH5GCE "CE ACHG=D>979# "]QQ ;US_\Q )#' @afcxvg g[x TVghTgbe Ybe g[x cexfxavx by YbeX\Za bu]xvgf TaW `T^X fhex g[tg g[x VTa\fgXe \f fxtgxw \a g[x TVghTgbe UXYbeX XTV[ hfx( )

DE>A>B<2 Ge\`\aZ Tg fcxv\y\xw g\`xf \f \`cbegtag Ybe g[x cebcxe WX_\iXel by lbhe `XW\VTg\ba( F=5?9 G=9 >B=5@9E J9@@3 g[xa ce\`x KCD9B9K =;5 >YTMWM^UZY 5Q\Z]ZW Ul ex_xtf\az. gxfg fcetlf \agb g[x T\e& TjTl Yeb` lbhe YTVX& UXYbeX hf\az Ybe g[x Y\efg g\`x TaW j[xa g[x \a[t_xe [Tf abg UXXa hfxw Ybe `bex g[ta - WTlf( +' 6E95G=9 CHG ;H@@L G=ECH<= LCHE ACHG=% XkcX \az Tf `hv[ T\e Yeb` lbhe _hazf Tf cbff\u_x( G_TVX g[x `bhg[c\xvx Yh l \agb lbhe `bhg[& [b_w\az g[x \a[t_xe \a g[x `bhg[c\xvx'wbja cbf\g\ba #]QQ ;US_\Q *$ TaW V_bf\aZ lbhe _\cf TebhaW \g(,' J=>@9 6E95G=>B< >B 899D@L 5B8 F@CJ@L G=ECH<= LCHE ACHG=% ;H@@L 89DE9FF G=9 GCD C; G=9 A9G5@ 75B>FG9E j\g[ lbhe `\WW_X Y\aZXe Tf f[bja \a ;US_\Q *' @``XW\TgX_l TYgXe g[x chyy \f WX_\iXeXW& ex_xtfx lbhe Y\aZXe Yeb` g[x VTa\fgXe TaW ex`bix g[x \a[t_xe Yeb` lbhe `bhg[( -' =C@8 LCHE 6E95G= ;CE )( F97CB8F% >; DCFF>6@9'.' @Y lbhe WbVgbe [Tf cexfve\uxw `bex g[ta T f\az_x \a[t_tg\ba)chyy& jt\g + `\ahgx UXgjXXa \a[t_tg\baf( K[Xa& F=5?9 G=9 >B=5@9E J9@@ TaW excxtg fgxcf - g[ebhz[ /( /' E9D@579 G=9 75D CB G=9 ACHG=D>979 5;G9E 957= HF9' 0' 7@95B G=9 57GH5GCE CE ACHG=D>979 5G @95FG CB79 5 J99?' JXX 7@95B>B< LCHE KCD9B9K =;5 >B=5@5G>CB 59ECFC@ Ybe V_XTa\aZ \afgehvg\baf( 1' 8>F75E8 G=9 75B>FG9E 5;G9E LCH =5I9 HF98 9>G=9E *(( >B=5@5G>CBF ;ECA G=9 )- S 75B>FG9E CE 0( >B=5@5G>CBF ;ECA G=9 0', S 75B>FG9E' K[X VbeeXVg T`bhag by `XW\V\aX \a XTV[ *

\a[t_tg\ba VTaabg UX TffheXW TYgXe,** fcetlf Yeb` g[x +/ Z VTa\fgXe be 2* fcetlf Yeb` g[x 2(. Z VTa\fgXe& XiXa g[bhz[ g[x VTa\fgXe \f abg Vb`c_XgX_l X`cgl( EXiXe \``XefX g[x VTa\fgXe \a jtgxe gb WXgXe`\aX [bj Yh g[x VTa\fgXe \f #oy_btg gxfgp$( 8XYbeX lbh extv[ X\g[Xe,** fcetlf be 2* fcetlf& lbh f[bh_w Vbafh_g lbhe WbVgbe gb WXgXe`\aX j[xg[xe T exy\ \f axxwxw( Ahfg Tf lbh f[bh_w abg gt^x XkgeT WbfXf j\g[bhg Vbafh_g\aZ lbhe WbVgbe& lbh T_fb f[bh_w abg fgbc hf\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ j\g[bhg Vbafh_g\aZ lbhe WbVgbe( 7@95B>B< LCHE KCD9B9K =;5 >B=5@5G>CB 59ECFC@?99D>B< G=9 6@H9 D@5FG>7 57GH5GCE "CE ACHG=D>979# 7@95B >F I9EL >ADCEG5BG GC DE9I9BG A98>7>B9 6@C7?5<9' G=9 57GH5GCE F=CH@8 69 J5F=98% F=5?9B GC E9ACI9 9K79FF J5G9E% 5B8 5>E&8E>98 G=CECH<=@L 5G @95FG CB79 5 J99?' G=9 >B=5@9E A5L FGCD JCE?>B< >; BCG DECD9E@L 7@95B98' ECHG>B9 7@95B>B< >BFGEH7G>CBF2 F^Q[ )' Kb V_XTa g[x U_hX c_tfg\v TVghTgbe #be `bhg[c\xvx$& ex`bix g[x VTa\fgXe TaW exw `bhg[c\xvx VTc( F^Q[ *' NTf[ g[x TVghTgbe g[ebhz[ g[x gbc TaW Ubggb` j\g[ jte` ehaa\az jtgxe Ybe -* fxvbawf Tg _XTfg bavx T jxx^ #]QQ ;US_\Q +$( 8Z YZ^ OWQMY ^TQ XQ^MW OMYU]^Q\ Z\ MWWZa ^TQ XQ^MW OMYU]^Q\ ^Z NQOZXQ aq^' BQ`Q\ UXXQ\]Q ^TQ XQ^MW OMYU]^Q\ UY am^q\' F^Q[ +' Kb Wel& f[t^x byy XkVXff jtgxe TaW _Xg g[x TVghTgbe T\e'Wel g[bebhz[_l& fhv[ Tf bixea\z[g #]QQ ;US_\Q,$( +

F^Q[,' N[Xa g[x TVghTgbe \f Wel& exc_tvx g[x VTa\fgXe TaW g[x `bhg[c\xvx VTc5 `T^X fhex g[x VTa\fgXe \f Yh l TaW Y\e`_l \afxegxw \agb g[x TVghTgbe( 8_bV^TZX Yeb` `XW\V\aX Uh\_W' hc \f `bex _\^X_l gb bvvhe \Y g[x TVghTgbe \f abg T bjxw gb T\e'Wel g[bebhz[_l( >; LCHE 57GH5GCE 697CA9F 6@C7?98 #_\gg_x be ab `XW\V\aX Vb`\aZ bhg by g[x `bhg[c\xvx& ]QQ ;US_\Q -$& jtf[ lbhe TVghTgbe Tf WXfVe\UXW \a F^Q[] ) MYP * TaW T\e' Wel g[bebhz[_l Tf WXfVe\UXW \a F^Q[ +' >; LCH B998 GC HF9 LCHE >B=5@9E 69;CE9 G=9 D@5FG>7 57GH5GCE >F 7CAD@9G9@L 8EL% F=5?9 9K79FF J5G9E byy g[x TVghTgbe& exc_tvx g[x VTa\fgXe& ]TMVQ aqww% TaW gxfg'fcetl gj\vx \agb g[x T\e& TjTl Yeb` lbhe YTVX& gb ex`bix `bfg by g[x jtgxe ex`t\a\az \a g[x TVghTgbe( K[Xa gt^x lbhe WbfX Tf cexfve\uxw( 5R^Q\,

]_OT _]Q% \QaM]T ^TQ MO^_M^Z\ MYP MU\&P\b U^ ^TZ\Z_STWb M] PQ]O\UNQP UY F^Q[] ) ^T\Z_ST +' 588>G>CB5@ >B;CEA5G>CB 56CHG KCD9B9K =;5 >B=5@5G>CB 59ECFC@ 8CF5<92 LfX ba_l Tf W\eXVgXW Ul lbhe WbVgbe( J5EB>B<F2 K[X TVg\ba by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w _Tfg Ybe. gb 0 [bhef( OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ f[bh_w abg UX hfxw `bex YeXdhXag_l g[ta exvb``xawxw( ;b abg \avextfx g[x WbfX be YeXdhXaVl by WbfXf by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ j\g[bhg Vbafh_g\aZ lbhe c[lf\v\ta( @Y lbh Y\aW g[tg gextg`xag j\g[ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ UXVb`Xf _Xff XYYXVg\iX Ybe fl`cgb`tg\v ex_\xy& lbhe fl`cgb`f UXVb`X jbefx& TaW)be lbh axxw gb hfx g[x cebwhvg `bex YeXdhXag_l g[ta hfht_& lbh f[bh_w fxx^ `XW\VT_ TggXag\ba \``XW\TgX_l( N[\_X lbh TeX hf\az OFG<E<O?=7 @a[t_tg\ba 7Xebfb_& bg[xe \a[t_xw WehZf TaW Tfg[`T `XW\VTg\ba f[bh_w UX gt^xa ba_l Tf W\eXVgXW Ul lbhe c[lf\v\ta( 9b``ba TWiXefX XYYXVgf \av_hwx ct_c\gtg\baf& V[Xfg ct\a& etc\w [XTeg etgx& gex`be& TaW axeibhfaxff( @Y lbh TeX cexzatag be ahef\az& VbagTVg lbhe c[lf\v\ta TUbhg g[x hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_( <YYXVg\iX TaW ftyx hfx by OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ \av_hwxf Ta hawxefgtaw\az by g[x jtl g[tg \g f[bh_w UX TW`\a\fgXeXW( @a ZXaXeT_& g[x gxv[a\dhx Ybe TW`\a\fgXe\aZ OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ gb V[\_WeXa \f f\`\_te gb g[tg Ybe TWh_gf( 9[\_WeXa f[bh_w hfx OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ hawxe TWh_g fhcxei\f\ba& Tf \afgehvgxw Ul g[x ctg\xagnf c[lf\v\ta( F^Z\MSQ2 JgbeX VTa\fgXe UXgjXXa,*t TaW,/t9 #02t TaW 11t=$( GebgXVg Yeb` YeXXm\aZ gx`cxetghexf TaW W\eXVg fha_\z[g( JgbeX \a[t_xe j\g[ g[x TVghTgbe #be `bhg[c\xvx$ Wbja( 9bagXagf hawxe cexffhex( ;b abg chavghex be \av\axetgx( <kcbfhex gb gx`cxetghexf TUbiX +,*t= `Tl VThfX Uhefg\aZ( 7ib\W fcetl\az \a XlXf( BXXc bhg by extv[ by V[\_WeXa( 7;7&;\QQ2 OFG<E<O?=7 @a[t_tg\ba 7Xebfb_ WbXf abg VbagT\a V[_bebY_hbebVTeUbaf #9=9f$( @afgxtw& g[x \a[t_xe VbagT\af T [lweby_hbebt_^tax #?=7'+-.T$ Tf g[x cebcx Tag( DTahYTVgheXW Ybe4 FQ[\MOZ\ >YO' DTe_UbebhZ[& D7 *+1/, LJ7 Ul -D ;ehz ;X_\iXel JlfgX`f Ebeg[e\WZX& 97 3+-,.'-,+- =be Vhfgb`Xe fxei\vx& VT +'222'-3.'1-11( Kb excbeg TWiXefX XiXagf& VT +'211'1-1'1,,0( =be `XW\VT_ \aybe`tg\ba& VT +'2**'1-3'*/0/( -

7hZhfg,**0 OOOOOO.