MscI SfiI EcoRI. M Y P Y D V P D Y A L M A M E A R I R S T E I S R G ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß

Átírás

1 nzymes : 51 of 242 enzymes (Filtered) ettings: Linear, Certain Sites Only, Standard Genetic Code MscI SfiI EcoRI SalI AccI BglII AvaI XhoI Page 1 Acc65I ATGTACCCATACGATGTTCCAGATTACGCTCTTATGGCCATGGAGGCCCGAATTCGGTCGACCGAGATCTCTCGAGGTA â â â â â â â 79 TACATGGGTATGCTACAAGGTCTAATGCGAGAATACCGGTACCTCCGGGCTTAAGCCAGCTGGCTCTAGAGAGCTCCAT HA TAG M Y P Y D V P D Y A L M A M E A R I R S T E I S R G ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß KpnI CCCGTCCGGCGTGCAAAATCCCGAACGACCTGAAACAGAAAGTCATGAACCACGACAAGCAGAAGAACGGCATCAAGGC â â â â â â â â 158 GGGCAGGCCGCACGTTTTAGGGCTTGCTGGACTTTGTCTTTCAGTACTTGGTGCTGTTCGTCTTCTTGCCGTAGTTCCG VENUS C155 T R P A C K I P N D L K Q K V M N H D K Q K N G I K A ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßß CAACTTCAAGATCCGCCACAACATCGAGGACGGCGGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCATCGGC â â â â â â â â 237 GTTGAAGTTCTAGGCGGTGTTGTAGCTCCTGCCGCCGCACGTCGAGCGGCTGGTGATGGTCGTCTTGTGGGGGTAGCCG VENUS C155 N F K I R H N I E D G G V Q L A D H Y Q Q N T P I G ß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßß GACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCTACCAGTCCGCCCTGAGCAAAGACCCCAACGAGAAGCGCG â â â â â â â â 316 CTGCCGGGGCACGACGACGGGCTGTTGGTGATGGACTCGATGGTCAGGCGGGACTCGTTTCTGGGGTTGCTCTTCGCGC VENUS C155 D G P V L L P D N H Y L S Y Q S A L S K D P N E K R ßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéß BsgI

2 Page 2 BsrGI EagI NotI ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAGTAAGCGGCCGC â â â â â â â â 395 TAGTGTACCAGGACGACCTCAAGCACTGGCGGCGGCCCTAGTGAGAGCCGTACCTGCTCGACATGTTCATTCGCCGGCG VENUS C155 D H M V L L E F V T A A G I T L G M D E L Y K. A A A ßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßé GGGGATCCAGACATGATAAGATACATTGATGAGTTTGGACAAACCACAACTAGAATGCAGTGAAAAAAATGCTTTATTT â â â â â â â â 474 CCCCTAGGTCTGTACTATTCTATGTAACTACTCAAACCTGTTTGGTGTTGATCTTACGTCACTTTTTTTACGAAATAAA G I Q T.. D T L M S L D K P Q L E C S E K N A L F ßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßß PsiI MfeI GTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAACAAGTTAACAACAACAATTGCATTCA â â â â â â â â 553 CACTTTAAACACTACGATAACGAAATAAACATTGGTAATATTCGACGTTATTTGTTCAATTGTTGTTGTTAACGTAAGT V K F V M L L L Y L. P L. A A I N K L T T T I A F éßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßß NheI BmtI TTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGTTTTTTCGGATCCTCTAGAGTCGATCTGCAGGCATGCTAGCTTG â â â â â â â â 632 AAAATACAAAGTCCAAGTCCCCCTCCACACCCTCCAAAAAAGCCTAGGAGATCTCAGCTAGACGTCCGTACGATCGAAC I L C F R F R G R C G R F F R I L. S R S A G M L A W ßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßß GCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCA â â â â â â â â 711 CGCATTAGTACCAGTATCGACAAAGGACACACTTTAACAATAGGCGAGTGTTAAGGTGTGTTGTATGCTCGGCCTTCGT R N H G H S C F L C E I V I R S Q F H T T Y E P E A ßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ß TAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTC â â â â â â â â 790 ATTTCACATTTCGGACCCCACGGATTACTCACTCGATTGAGTGTAATTAACGCAACGCGAGTGACGGGCGAAAGGTCAG. S V K P G V P N E. A N S H. L R C A H C P L S S ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß

3 Page 3 BsaXI' BsaXI SapI GGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCC â â â â â â â 869 CCCTTTGGACAGCACGGTCGACGTAATTACTTAGCCGGTTGCGCGCCCCTCTCCGCCAAACGCATAACCCGCGAGAAGG R E T C R A S C I N E S A N A R G E A V C V L G A L P ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß GCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATAC â â â â â â â â 948 CGAAGGAGCGAGTGACTGAGCGACGCGAGCCAGCAAGCCGACGCCGCTCGCCATAGTCGAGTGAGTTTCCGCCATTATG L P R S L T R C A R S F G C G E R Y Q L T Q R R. Y ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßß AflIII PciI GGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAA â â â â â â â â 1027 CCAATAGGTGTCTTAGTCCCCTATTGCGTCCTTTCTTGTACACTCGTTTTCCGGTCGTTTTCCGGTCCTTGGCATTTTT G Y P Q N Q G I T Q E R T C E Q K A S K R P G T V K ß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßß GGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGG â â â â â â â â 1106 CCGGCGCAACGACCGCAAAAAGGTATCCGAGGCGGGGGGACTGCTCGTAGTGTTTTTAGCTGCGAGTTCAGTCTCCACC R P R C W R F S I G S A P L T S I T K I D A Q V R G G ßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéß CGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGC â â â â â â â â 1185 GCTTTGGGCTGTCCTGATATTTCTATGGTCCGCAAAGGGGGACCTTCGAGGGAGCACGCGAGAGGACAAGGCTGGGACG E T R Q D Y K D T R R F P L E A P S C A L L F R P C ßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßé CGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAG â â â â â â â â 1264 GCGAATGGCCTATGGACAGGCGGAAAGAGGGAAGCCCTTCGCACCGCGAAAGAGTATCGAGTGCGACATCCATAGAGTC R L P D T C P P F S L R E A W R F L I A H A V G I S ßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßß

4 Page 4 BseYI TTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGT â â â â â â â â 1343 AAGCCACATCCAGCAAGCGAGGTTCGACCCGACACACGTGCTTGGGGGGCAAGTCGGGCTGGCGACGCGGAATAGGCCA V R C R S F A P S W A V C T N P P F S P T A A P Y P V éßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßß AlwNI AACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAG â â â â â â â â 1422 TTGATAGCAGAACTCAGGTTGGGCCATTCTGTGCTGAATAGCGGTGACCGTCGTCGGTGACCATTGTCCTAATCGTCTC T I V L S P T R. D T T Y R H W Q Q P L V T G L A E ßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßß CGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTAT â â â â â â â â 1501 GCTCCATACATCCGCCACGATGTCTCAAGAACTTCACCACCGGATTGATGCCGATGTGATCTTCCTGTCATAAACCATA R G M. A V L Q S S. S G G L T T A T L E G Q Y L V ßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ß CTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGC â â â â â â â â 1580 GACGCGAGACGACTTCGGTCAATGGAAGCCTTTTTCTCAACCATCGAGAACTAGGCCGTTTGTTTGGTGGCGACCATCG S A L C. S Q L P S E K E L V A L D P A N K P P L V A ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß GGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGG â â â â â â â 1659 CCACCAAAAAAACAAACGTTCGTCGTCTAATGCGCGTCTTTTTTTCCTAGAGTTCTTCTAGGAAACTAGAAAAGATGCC V V F L F A S S R L R A E K K D L K K I L. S F L R ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß GGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGAT â â â â â â â â 1738 CCAGACTGCGAGTCACCTTGCTTTTGAGTGCAATTCCCTAAAACCAGTACTCTAATAGTTTTTCCTAGAAGTGGATCTA G L T L S G T K T H V K G F W S. D Y Q K G S S P R ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßß

5 Page 5 CCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTA â â â â â â â â 1817 GGAAAATTTAATTTTTACTTCAAAATTTAGTTAGATTTCATATATACTCATTTGAACCAGACTGTCAATGGTTACGAAT S F. I K N E V L N Q S K V Y M S K L G L T V T N A. ß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßß ATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTA â â â â â â â â 1896 TAGTCACTCCGTGGATAGAGTCGCTAGACAGATAAAGCAAGTAGGTATCAACGGACTGAGGGGCAGCACATCTATTGAT S V R H L S Q R S V Y F V H P. L P D S P S C R. L ßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéß AhdI BsaI BsrFI CGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATC â â â â â â â â 1975 GCTATGCCCTCCCGAATGGTAGACCGGGGTCACGACGTTACTATGGCGCTCTGGGTGCGAGTGGCCGAGGTCTAAATAG R Y G R A Y H L A P V L Q. Y R E T H A H R L Q I Y ßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßé AGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAAT â â â â â â â â 2054 TCGTTATTTGGTCGGTCGGCCTTCCCGGCTCGCGTCTTCACCAGGACGTTGAAATAGGCGGAGGTAGGTCAGATAATTA Q Q. T S Q P E G P S A E V V L Q L Y P P P S S L L I ßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßß TGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGG â â â â â â â â 2133 ACAACGGCCCTTCGATCTCATTCATCAAGCGGTCAATTATCAAACGCGTTGCAACAACGGTAACGATGTCCGTAGCACC V A G K L E. V V R Q L I V C A T L L P L L Q A S W éßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßß TGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTT â â â â â â â â 2212 ACAGTGCGAGCAGCAAACCATACCGAAGTAAGTCGAGGCCAAGGGTTGCTAGTTCCGCTCAATGTACTAGGGGGTACAA C H A R R L V W L H S A P V P N D Q G E L H D P P C ßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßß

6 Page 6 GTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTT â â â â â â â â 2291 CACGTTTTTTCGCCAATCGAGGAAGCCAGGAGGCTAGCAACAGTCTTCATTCAACCGGCGTCACAATAGTGAGTACCAA C A K K R L A P S V L R S L S E V S W P Q C Y H S W L ßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ß ATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGT â â â â â â â â 2370 TACCGTCGTGACGTATTAAGAGAATGACAGTACGGTAGGCATTCTACGAAAAGACACTGACCACTCATGAGTTGGTTCA W Q H C I I L L L S C H P. D A F L. L V S T Q P S ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ScaI BcgI BcgI' CATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAG â â â â â â â 2449 GTAAGACTCTTATCACATACGCCGCTGGCTCAACGAGAACGGGCCGCAGTTATGCCCTATTATGGCGCGGTGTATCGTC H S E N S V C G D R V A L A R R Q Y G I I P R H I A ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß XmnI AACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGT â â â â â â â â 2528 TTGAAATTTTCACGAGTAGTAACCTTTTGCAAGAAGCCCCGCTTTTGAGAGTTCCTAGAATGGCGACAACTCTAGGTCA E L. K C S S L E N V L R G E N S Q G S Y R C. D P V ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßß TCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAG â â â â â â â â 2607 AGCTACATTGGGTGAGCACGTGGGTTGACTAGAAGTCGTAGAAAATGAAAGTGGTCGCAAAGACCCACTCGTTTTTGTC R C N P L V H P T D L Q H L L L S P A F L G E Q K Q ß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßß GAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTA â â â â â â â â 2686 CTTCCGTTTTACGGCGTTTTTTCCCTTATTCCCGCTGTGCCTTTACAACTTATGAGTATGAGAAGGAAAAAGTTATAAT E G K M P Q K R E. G R H G N V E Y S Y S S F F N I ßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéß SspI

7 Page 7 TTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTT â â â â â â â â 2765 AACTTCGTAAATAGTCCCAATAACAGAGTACTCGCCTATGTATAAACTTACATAAATCTTTTTATTTGTTTATCCCCAA I E A F I R V I V S. A D T Y L N V F R K I N K. G F ßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßé CCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCTAAGAAACCATTATTATCATGACATTAACCTATAAAAATAGGC â â â â â â â â 2844 GGCGCGTGTAAAGGGGCTTTTCACGGTGGACTGCAGATTCTTTGGTAATAATAGTACTGTAATTGGATATTTTTATCCG R A H F P E K C H L T S K K P L L S. H. P I K I G ßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßß GTATCACGAGGCCCTTTCGTCTCGCGCGTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGT â â â â â â â â 2923 CATAGTGCTCCGGGAAAGCAGAGCGCGCAAAGCCACTACTGCCACTTTTGGAGACTGTGTACGTCGAGGGCCTCTGCCA V S R G P F V S R V S V M T V K T S D T C S S R R R éßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßß CACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGC â â â â â â â â 3002 GTGTCGAACAGACATTCGCCTACGGCCCTCGTCTGTTCGGGCAGTCCCGCGCAGTCGCCCACAACCGCCCACAGCCCCG S Q L V C K R M P G A D K P V R A R Q R V L A G V G A ßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßß BstAPI TGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAA â â â â â â â â 3081 ACCGAATTGATACGCCGTAGTCTCGTCTAACATGACTCTCACGTGGTATACGCCACACTTTATGGCGTGTCTACGCATT G L T M R H Q S R L Y. E C T I C G V K Y R T D A. ßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ß KasI NarI SfoI BbeI GGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTC â â â â â â â â 3160 CCTCTTTTATGGCGTAGTCCGCGGTAAGCGGTAAGTCCGACGCGTTGACAACCCTTCCCGCTAGCCACGCCCGGAGAAG G E N T A S G A I R H S G C A T V G K G D R C G P L ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß

8 Page 8 GCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGA â â â â â â â 3239 CGATAATGCGGTCGACCGCTTTCCCCCTACACGACGTTCCGCTAATTCAACCCATTGCGGTCCCAAAAGGGTCAGTGCT R Y Y A S W R K G D V L Q G D. V G. R Q G F P S H D ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß BspMI SbfI CGTTGTAAAACGACGGCCAGTGAGTTCGAGCTTGCATGCCTGCAGGTCGTTACATAACTTACGGTAAATGGCCCGCCTG â â â â â â â â 3318 GCAACATTTTGCTGCCGGTCACTCAAGCTCGAACGTACGGACGTCCAGCAATGTATTGAATGCCATTTACCGGGCGGAC V V K R R P V S S S L H A C R S L H N L R. M A R L ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßß GCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCA â â â â â â â â 3397 CGACTGGCGGGTTGCTGGGGGCGGGTAACTGCAGTTATTACTGCATACAAGGGTATCATTGCGGTTATCCCTGAAAGGT A D R P T T P A H. R Q.. R M F P.. R Q. G L S ß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßß TTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCC â â â â â â â â 3476 AACTGCAGTTACCCACCTCATAAATGCCATTTGACGGGTGAACCGTCATGTAGTTCACATAGTATACGGTTCATGCGGG I D V N G W S I Y G K L P T W Q Y I K C I I C Q V R P ßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéß CCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGC â â â â â â â â 3555 GGATAACTGCAGTTACTGCCATTTACCGGGCGGACCGTAATACGGGTCATGTACTGGAATACCCTGAAAGGATGAACCG L L T S M T V N G P P G I M P S T. P Y G T F L L G ßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßé BsaAI SnaBI AGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTT â â â â â â â â 3634 TCATGTAGATGCATAATCAGTAGCGATAATGGTACCACTACGCCAAAACCGTCATGTAGTTACCCGCACCTATCGCCAA S T S T Y. S S L L P W. C G F G S T S M G V D S G ßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßß

9 Page 9 EcoICR TGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTT â â â â â â â â 3713 ACTGAGTGCCCCTAAAGGTTCAGAGGTGGGGTAACTGCAGTTACCCTCAAACAAAACCGTGGTTTTAGTTGCCCTGAAA L T H G D F Q V S T P L T S M G V C F G T K I N G T F éßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßß CCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAG â â â â â â â â 3792 GGTTTTACAGCATTGTTGAGGCGGGGTAACTGCGTTTACCCGCCATCCGCACATGCCACCCTCCAGATATATTCGTCTC Q N V V T T P P H. R K W A V G V Y G G R S I. A E ßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßß SacI BbsI CTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATC â â â â â â â â 3871 GAGCAAATCACTTGGCAGTCTAGCGGACCTCTGCGGTAGGTGCGACAAAACTGGAGGTATCTTCTGTGGCCCTGGCTAG L V.. T V R S P G D A I H A V L T S I E D T G T D ßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ß BspEI CAGCCTCCGGACTCTAGAGGATCCGGTACTAGAGGAACTGAAAAACCAGAAAGTTAACTGGTAAGTTTAGTCTTTTTGT â â â â â â â â 3950 GTCGGAGGCCTGAGATCTCCTAGGCCATGATCTCCTTGACTTTTTGGTCTTTCAATTGACCATTCAAATCAGAAAAACA P A S G L. R I R Y. R N. K T R K L T G K F S L F V ßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß PpuMI BseRI StuI CTTTTATTTCAGGTCCCGGATCCGGTGGTGGTGCAAATCAAAGAACTGCTCCTCAGTGGATGTTGCCTTTACTTCTAGG â â â â â â â 4029 GAAAATAAAGTCCAGGGCCTAGGCCACCACCACGTTTAGTTTCTTGACGAGGAGTCACCTACAACGGAAATGAAGATCC F Y F R S R I R W W C K S K N C S S V D V A F T S R ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß

10 T p Page 10 PspOMI ApaI CCTGTACGGAAGTGTTACTTCTGCTCTAAAAGCTGCGGAATTGTACCCGCGGGCCCACC â â â â â â í 4088 GGACATGCCTTCACAATGAAGACGAGATTTTCGACGCCTTAACATGGGCGCCCGGGTGG P V R K C Y F C S K S C G I V P A G P P ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßßß ßßßßéßßí